Abstract: The object of the present invention is to provide an amino acid frame indication system, a method for amino acid frame indication and a recording medium, which can effectively extract a highly reliable amino acid sequence from a cDNA sequence, even in a case where there exists a frame shift error in the cDNA sequence.

Abstract: The present invention provides a method for graphically indicating a correspondence between cDNA and genome sequences having an exon-intron structure to be understood easily. From search results of the similarity between a cDNA and a genome, information on the base positions of both edges of similar subsequence pairs (exon), the similarity value thereof, etc. is extracted. From such information, information on subsequence pairs determined unlikely to be significant in view of the similarity value, base length, etc., is eliminated. Furthermore, the conformity of orientation and order between exons is examined, and only an exon covering the cDNA by not less than a qualified ratio and whose correspondence to the cDNA is clear is selected. The selected exon is indicated by a segment on a graph by locating a base position on the genome sequence to an axis 1 and a base position on the cDNA sequence to another axis of the graph, thereby confirming the intron-exon structure visually as a line of segments.

Abstract: A method of driving a CCD semiconductor delay line capable of providing a good delay characteristic without externally supplying a clock signal. An intermittent reference signal is extracted from the color burst signal of an inputted television signal. Using the intermittent reference signal, a continuous reference signal is generated by a phase locked loop. The continuous reference signal drives a CCD semiconductor delay line to delay the television signal.

Abstract: DNA molecule length can be measured with high precision and efficiency by 1) using such means as electrophoresis gel migration to orient a DNA molecule having a fluorescence label at both its termini into a straight line by its passing through a migration path having in a portion of it an area not more than several micrometers in diameter, detecting the fluorescence label at both the termini at a predetermined location and measuring the interval between the detection of the fluorescence coming from one terminus and that of the fluorescence from the other or by 2) a DNA molecule bound to a fluorescence label at one terminus and to a particle at the other being led as a whole by such means as electric field application into an aperture smaller in diameter than the particle, leaving the particle fixed at the mouth of the aperture to stretch the DNA molecule and detecting the fluorescence position to measure the distance between the bound particle and the bound fluorescence label.

Abstract: A multicolor fluorescence detection type electrophoresis apparatus comprises an electrophoretic device having migration lanes in which fragment groups specifically labeled by fluorophores of different light emission peak wavelengths are mixed, added, and migrated. It identifies and detects the fragment groups. It uses laser beams of different wavelengths for exciting the fluorophores in the migration lanes. The laser beams are irradiated to separate positions on the migration lanes for detection of a few kinds of fluorophores at irradiation positions. For the purpose, multicolor optical filters are arranged near the irradiation positions to identify and detect lights emitted from the fluorophores excited by wavelength at every irradiation position.

Abstract: A charge coupled device (CCD) has a charge storage region and a potential barrier region. The CCD includes a first layer made of a first conductivity type semiconductor, a second layer made of a second conductivity type semiconductor and provided on the first layer, where the first and second conductivity types are mutually opposite types selected from n-type and p-type semiconductors, a third layer made of a first conductivity type semiconductor, impurity diffusion regions provided in at least a surface part of the third layer and having an impurity density higher than that of the third layer, a first gate electrode provided on the third layer between two mutually adjacent impurity diffusion regions, and a second gate electrode provided on each impurity diffusion region of the third layer. The impurity diffusion region forms the charge storage region of the CCD and the third layer between the two mutually adjacent impurity diffusion regions forms the potential barrier region of the CCD.

Abstract: In a fluorescence detection type electrophoresis apparatus, comprising an electrophoresis separation gel plate (2, 102, 205), an excitation laser beam source (3, 201, 201) for emitting fluorescent light, and a fluorescent light detector (9, 109, 212) for detecting the emitted fluorescent light, a fluorescent light images are divided into a plurality of virtual images by an image divider (5, 7.sub.2, 104, 105, 209) and at the same time, the lights corresponding to the individual divided images are wavelength-selected by bandpass filters (8, 8.sub.3, 107, 108, 120, 227-230), thereby providing highly accurate, sensitive separation and detection of DNA fragments and the like and determination of base sequence of DNA and the like.

Abstract: In an electrophoresis apparatus for separating and detecting a sample of DNA or RNA labelled with fluorescence, use is made of a gel plate having a polyacrylamide concentration of 2 to 6% in order to greatly shorten the time required for the measurement.

Abstract: Field isolation between arrayed picture cells of an image sensor is fabricated thinner than the insulation layer for the peripheral portion of CCD operatively connected to picture cells. The field isolation is fabricated by a selective thermal oxidization, by which the isolation film inflates not only vertically but also laterally, therefore the thinner isolation layer can be narrower. And, the lower applied voltage to the picture cell than applied voltage to the CCD portion allows the narrower isolation. The narrower field isolation between the picture cells allows greater density of integration of the picture cells. Procedures to embody the invention are disclosed, one of which is to fabricate the thinner isolation first, and another one is the thicker insulation layer first.

Abstract: An image sensor includes a plurality of potential monitoring transistors connected to respective floating electrodes for separately monitoring changes in potential of the respective floating electrodes. In addition, the image sensor includes an output circuit for producing an output signal which varies in accordance with one of the monitored potentials which is one of the highest potential and the lowest potential.

Abstract: A web butt splicing device for splicing two successive webs by butting the following end of a first roll of web and the leading end of a second roll of web against each other. In the web splicing device, the following end of the first roll of web is cut and is then drawn to and held on the hold surface of a butt splicing table. The leading end of the second web roll is cut on a provisionally positioning table to the shape of the following end of the first web roll, is then carried to the butt splicing table by a carrying device and is butt spliced to the following end of the first web roll. Therefore, according to the web splicing device, the webs can be butt spliced together without recourse to a manual operation.

Abstract: An electrophoresis gel is regenerated by light-irradiating an electrophoresis gel used for separating a fluorescence-labeled sample by electrophoresis and optically detecting the sample, thereby photo-dissociating a fluorescence-labeling substance remaining in the electrophoresis gel and reutilizing the resulting gel repeatedly. A troublesome operation of preparing an electrophoresis gel at every occasion of separation and detection can be saved thereby.