Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: An X-ray image diagnosis apparatus includes an X-ray tube, an X-ray detector, a fluid information acquisition unit, a registration unit, and a capturing direction controller. The X-ray tube emits X-rays toward a subject. The X-ray detector detects the X-rays having passed through the subject. The fluid information acquisition unit acquires fluid information on a target site including a region of interest of the subject captured by an ultrasound image diagnosis apparatus. The registration unit extracts position information of a probe of the ultrasound image diagnosis apparatus. The capturing direction controller controls capturing direction for capturing the target site based on the position information and a direction in which a fluid flows indicated by the fluid information.

Abstract: In one embodiment, a medical image processing apparatus includes a display and processing circuitry. The processing circuitry is configured to (a) calculate fluid information including flow-velocity vectors based on three-dimensional image data of plural time phases, which are acquired by a phase contrast method of magnetic resonance imaging, and in which fluid flowing inside a lumen is depicted, (b) identify a branching position where a second lumen branches from a first lumen, based on change in flow volume of fluid flowing inside the first lumen along an extending direction of the first lumen, and (c) cause the display to display an analysis result including fluid information of fluid flowing inside the second lumen, based on the branching position.

Abstract: Probability of prize occurrence is easily controlled without provision of a blank between symbols on a reel. A gaming machine comprises: a lower image display panel configured to variably display a plurality of symbol arrays with a plurality of symbols including normal symbols and specific symbols more advantageous than the normal symbols, and then display a game result by rearranging the symbols in a symbol display region containing a matrix of cells; bet buttons capable of receiving a bet; and a controller configured to run a normal game which rearranges symbols on the symbol display device on condition that a bet is placed, the controller is configured to modify the symbols arrayed in the plurality of symbol arrays, so that the ratios of the specific symbols to the total number of the symbols in all the symbol arrays increases with an increase in the bet amount.

Abstract: A gaming machine achieves a new entertainment characteristic by adding a new characteristic to selection of a bonus type. A gaming machine comprises: a lower image display panel configured to display selectable images in a bonus game which is triggered in a normal game, wherein the selectable images are changed to any one of bonus rank images corresponding to bonus types every time selection is made; a control panel enabling selection of one of the selectable images; and a controller configured to control the display panel so that only the number of the bonus rank images corresponding to the bonus determined in advance in the bonus game reaches a predetermined number, wherein the controller displays a bonus rank image corresponding to a high rank bonus type out of bonus types, before the number of the bonus rank images corresponding to the bonus determined in advance reaches the predetermined number.

Abstract: According to embodiment, a medical image processing apparatus includes input interface circuitry and processing circuitry. The input interface circuitry inputs at least three landmarks in a first and second slice image group. The processing circuitry determines, in each of the first and second slice image group, a first axis connecting two points in the landmarks and a second axis that passes through another point different from the two points and is orthogonal to the first axis. The processing circuitry performs a registration between first slice images belonging to the first slice image group and second slice images belonging to the second slice image group by using the first and second axes in the first slice image group and the first and second axes in the second slice image group.

Abstract: An image processing display and an image processing display program that can prevent interference with catheter treatment even when the distal end of a catheter is located behind a treatment apparatus on X-ray fluoroscopic images. The image processing display displays X-ray fluoroscopic images to be obtained by looking through a region including blood vessels using X-rays during treatment, and includes a treatment apparatus image extractor and an image processor. The treatment apparatus image extractor, based on X-ray fluoroscopic images, extracts treatment apparatus images representing the treatment apparatus having the property of absorbing X-rays. The image processor determines the distal end position of the catheter to superimpose and display images representing the determined distal end position of the catheter on the region of the X-ray fluoroscopic images showing the treatment apparatus.

Abstract: In one embodiment, a medical image processing apparatus includes a display and processing circuitry. The processing circuitry is configured to (a) calculate fluid information including flow-velocity vectors based on three-dimensional image data of plural time phases, which are acquired by a phase contrast method of magnetic resonance imaging, and in which fluid flowing inside a lumen is depicted, (b) identify a branching position where a second lumen branches from a first lumen, based on change in flow volume of fluid flowing inside the first lumen along an extending direction of the first lumen, and (c) cause the display to display an analysis result including fluid information of fluid flowing inside the second lumen, based on the branching position.

Abstract: An X-ray image diagnosis apparatus includes an X-ray tube, an X-ray detector, a fluid information acquisition unit, a registration unit, and a capturing direction controller. The X-ray tube emits X-rays toward a subject. The X-ray detector detects the X-rays having passed through the subject. The fluid information acquisition unit acquires fluid information on a target site including a region of interest of the subject captured by an ultrasound image diagnosis apparatus. The registration unit extracts position information of a probe of the ultrasound image diagnosis apparatus. The capturing direction controller controls capturing direction for capturing the target site based on the position information and a direction in which a fluid flows indicated by the fluid information.

Abstract: According to embodiment, a medical image processing apparatus includes input interface circuitry and processing circuitry. The input interface circuitry inputs at least three landmarks in a first and second slice image group. The processing circuitry determines, in each of the first and second slice image group, a first axis connecting two points in the landmarks and a second axis that passes through another point different from the two points and is orthogonal to the first axis. The processing circuitry performs a registration between first slice images belonging to the first slice image group and second slice images belonging to the second slice image group by using the first and second axes in the first slice image group and the first and second axes in the second slice image group.

Abstract: Probability of prize occurrence is easily controlled without provision of a blank between symbols on a reel. A gaming machine comprises: a lower image display panel configured to variably display a plurality of symbol arrays with a plurality of symbols including normal symbols and specific symbols more advantageous than the normal symbols, and then display a game result by rearranging the symbols in a symbol display region containing a matrix of cells; bet buttons capable of receiving a bet; and a controller configured to run a normal game which rearranges symbols on the symbol display device on condition that a bet is placed, the controller is configured to modify the symbols arrayed in the plurality of symbol arrays, so that the ratios of the specific symbols to the total number of the symbols in all the symbol arrays increases with an increase in the bet amount.

Abstract: A gaming machine achieves a new entertainment characteristic by adding a new characteristic to selection of a bonus type. A gaming machine comprises: a lower image display panel configured to display selectable images in a bonus game which is triggered in a normal game, wherein the selectable images are changed to any one of bonus rank images corresponding to bonus types every time selection is made; a control panel enabling selection of one of the selectable images; and a controller configured to control the display panel so that only the number of the bonus rank images corresponding to the bonus determined in advance in the bonus game reaches a predetermined number, wherein the controller displays a bonus rank image corresponding to a high rank bonus type out of bonus types, before the number of the bonus rank images corresponding to the bonus determined in advance reaches the predetermined number.

Abstract: According to one embodiment, a medical image processing apparatus includes at least a vascular region extracting unit, a vascular shape image generating unit, a perfusion analyzing unit, a perfusion image generating unit, an image composition unit. The vascular region extracting unit extracts a vascular region based on a three-dimensional medical image. The vascular shape image generating unit generates an image of a vascular shape of the vascular region. The perfusion analyzing unit performs perfusion analysis on the three-dimensional medical image and obtains a perfusion value indicating a blood circulation condition in tissue around the vascular region. The perfusion image generating unit generates an image indicating the perfusion value. The image composition unit generates a vascular shape perfusion composition image in which an image of the vascular shape in a contraction portion in a blood vessel corresponding to the vascular region is combined with the image indicating the perfusion value.

Abstract: A slot machine has a frontward projecting portion which is projected frontward of the slot machine from a lower end of a main display provided in a cabinet. The frontward projecting portion has an armrest, a control panel, etc., each of which serves as a human contact portion which comes in contact with a part of a player's body. The lower end of a display surface of the main display is positioned lower than the human contact portions (armrest and control panel).

Abstract: To provide an image processing display and an image processing display program that is able to prevent interference with catheter treatment even when the distal end of a catheter is located behind a treatment apparatus on X-ray fluoroscopic images. The image processing display according to embodiments displays X-ray fluoroscopic images to be obtained by looking through a region including blood vessels using X-rays during treatment, and comprises a treatment apparatus image extractor and an image processor. The treatment apparatus image extractor, based on X-ray fluoroscopic images, extracts treatment apparatus images representing the treatment apparatus having the property of absorbing X-rays. The image processor determines the distal end position of the catheter to superimpose and display images representing the determined distal end position of the catheter on the region of the X-ray fluoroscopic images showing the treatment apparatus.

Abstract: Positioning images are created by a projection-image creating unit before imaging, and the positioning images are grouped and stored by a projection-image storage unit for each preset. When imaging is started, a positioning-information calculating unit calculates positioning parameters using the positioning images stored in the projection-image storage unit. An analysis-image-for-synthesis creating unit creates an analysis image using the positioning parameters, and an analysis-image synthesizing and displaying unit synthesizes the analysis image with a live image and displays a synthesized image. When an imaging direction of an X-ray angiography apparatus is changed, a positioning-information updating unit directly updates the positioning parameters based on an amount of change of the imaging direction.

Abstract: A roulette board, including a roulette wheel on which a plurality of symbols are arranged in a circumferential direction of the roulette wheel, a plurality of ball reception portions that are provided in a one-to-one correspondence with the plurality of symbols, the plurality of ball reception portions being configured to receive a ball that rolls on the roulette wheel, a banked passage that is endlessly provided along an outer circumference of the roulette wheel, and allows the ball to roll in a circumferential orbit, and a ball discharging mechanism that is provided with a ball discharging member and discharges the ball received in one of the plurality of ball reception portions from the one of the plurality of ball reception portions toward the banked passage by bringing the ball discharging member into contact with the ball.

Abstract: According to one embodiment, a medical image processing apparatus includes at least a vascular region extracting unit, a vascular shape image generating unit, a perfusion analyzing unit, a perfusion image generating unit, an image composition unit. The vascular region extracting unit extracts a vascular region based on a three-dimensional medical image. The vascular shape image generating unit generates an image of a vascular shape of the vascular region. The perfusion analyzing unit performs perfusion analysis on the three-dimensional medical image and obtains a perfusion value indicating a blood circulation condition in tissue around the vascular region. The perfusion image generating unit generates an image indicating the perfusion value. The image composition unit generates a vascular shape perfusion composition image in which an image of the vascular shape in a contraction portion in a blood vessel corresponding to the vascular region is combined with the image indicating the perfusion value.

Abstract: A medical image processing apparatus includes a morphological identification part, a function calculator and a display processor. The morphological identification part identifies morphological information related to thickness of a heart muscle of a subject or thickness of surrounding sites thereof from medical image data obtained by capturing an image of the subject using a medical imaging apparatus. The function calculator determines cardiac function information related to movement of the heart muscle of the subject based on the medical image data. The display processor causes a display to display a combination of the identified morphological information and the calculated cardiac function information which is identified by color. The medical image processing apparatus can easily diagnose diseases.

Abstract: A roulette apparatus includes: a roulette wheel having a rolling region where a ball rolls; and a ball reception member provided contiguously to the rolling region to receive the ball. The ball reception member includes: a plurality of reception portions that receives the ball in one of the reception portions; and a plurality of separation walls that separates the reception portions from one another, wherein the ball reception member is formed separately from the roulette wheel and removably attached to the roulette wheel.