Abstract: The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.

Abstract: Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.

Abstract: The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods.

Abstract: Device for determining location information, primary references consolidated for an aircraft, comprising a chain for determining location information comprising means for measuring radionavigation data, suitable means for consolidating, suitable means for computing parameters and suitable means for consolidating the parameters. The device also comprises a chain for determining inertial primary references comprising means for measuring inertial data, suitable means for consolidating, suitable means for computing parameters and suitable means for consolidating the parameters. The device finally comprises a chain for determining anemo-barometric data comprising means for measuring anemo-barometric data, suitable means for consolidating the measured anemo-barometric data, suitable means for computing parameters, and suitable means for consolidating the reference parameters.

Abstract: The present invention relates to the field of insect pests control, using methods and compositions which comprise of alpha-amylase analogous mutant inhibitors (?AIs). More specifically, the invention provides new ?AIs analogous mutant molecules for controlling insect pests, in particular boll weevils (Anthonomus grandis), partially or totally presenting reduction of the amylolytic activity of the digestive enzymes in the intestinal lumen of the insect. Other aspects of the invention include gene constructs containing the nucleic acid molecules that code for the alpha-amylase inhibitors, heterologous expression methods of the new molecules in the active form, and the use of these molecules for controlling insect pests. The invention also provides analogous synthetic genes optimized for their transformation and expression in plants.

Abstract: Aptamers that bind IL-6 are provided. Pharmaceutical compositions comprising IL-6 aptamers are provided, as well as methods of treating conditions using the aptamers are also provided.

Abstract: A method includes estimating a position of a receiver, aboard a moving object, on the basis of the navigation signals emitted by satellites received by an antenna in an antenna array placed on the moving object, and using a three-dimensional geographical map to deduce, geometrically, on the basis of the position of the receiver and of a ray casting starting from the receiver, the number of paths reflected on walls of buildings present in a scene corresponding to an environment surrounding the receiver. The determined number of reflected paths is used to initialize an algorithm for estimating angles of arrival of multi-paths to deduce therefrom angles of arrival of the paths reflected on the walls before reaching the receiver. Optionally, the method can comprise making it possible to bound the distance information error due to a multi-path to render the estimation of direction of arrival of the signals more efficacious.

Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.

Abstract: The invention relates to a device for receiving satellite radio-navigation signals comprising a plurality of receiving antennas forming an antenna array. The invention consists in using a plurality of antennas disposed around the circumference of a carrier and in demodulating the signals received by each antenna separately. The diversity of the demodulation chains is utilized to compensate the signal loss on one of the chains when the corresponding antenna experiences a signal loss due to the masking of the satellite by the carrier.

Abstract: The invention pertains to a logic circuit device comprising at least one digital input furnished with a fuse (FUS) being, in the closed state, suitable for applying an electrical input voltage of the logic circuit corresponding to a first logic state from among the logic states 0 and 1, and, in the definitive open state, suitable for applying an electrical input voltage of the logic circuit corresponding to the second logic state from among the logic states 0 and 1, said fuse (FUS) being suitable for being placed definitively in the second logic state by injection of a current greater than a threshold current (CS).

Abstract: A horn that radiates a radioelectric wave coming from an input waveguide, comprises a grating placed over the aperture of the horn. The waveguide comprises a horn-shaped segment, an entrance, an aperture, and a grating placed next to the aperture. It makes it possible for at least one linearly polarised electromagnetic wave to propagate between the entrance and the aperture along a first axis. The grating comprises a frame and a set of plates extending longitudinally and continuously from a first short side of the frame to a second short side of the frame, so as to form a linear polarising filter for any electromagnetic wave the electric field of which is not polarised along a second axis orthogonal to the first axis. The grating of the waveguide comprises corrugations to reinforce the filtering of the electromagnetic wave the electric field of which is not polarised along the second axis.

Abstract: A lateral wellbore completion apparatus may include a flow-through deflector having a deflector face and a junction string that includes a junction block cooperative to mate with the deflector face, a downhole device, and an inductive coupler electrically connected to the downhole device. A method may include anchoring the deflector in a main bore, making-up at the drilling surface a junction string that includes a junction block, a completion string section having a downhole device, and a secondary inductive coupler electrically connected to the downhole device, running the junction string into the main bore, deflecting the completion string section into the lateral bore, and landing the junction block on the deflector face thereby communicatively coupling the secondary and primary inductive couplers.

Abstract: A method and device for determining a shifted circular segment on the basis of an initial circular segment, the shifted circular segment being shifted by a shift distance, the method being implemented by a computer dedicated to flight management, comprises: determining a shifted final point terminating a shifted circular segment, on the basis of the final point terminating the initial circular segment, through a shift of the final point determined on the basis of the shift distance and in the direction of shift, through the use of a straight line passing through the centre of the initial circular segment and the final point of the initial circular segment, and determining a shifted circular segment on the basis of the initial circular segment by construction of a circular segment between the shifted final point associated with the preceding shifted segment and the shifted final point associated with the shifted segment.

Abstract: Software defined radio equipment is provided. The equipment includes a software defined radio emission/reception radio sub-system, a primary software defined radio application and a secondary software defined radio application capable of interfacing with the radio emission/reception sub-system. The primary software defined radio application is a telecommunications application and the secondary software defined radio application is a cognitive radio application. A software defined radio emission/reception radio sub-system is also provided.

Abstract: A system for rescue of a target by aircraft, comprises control means to plot at least one contour delimiting an area of interest, computation means identifying, on at least one camera, at least one area of interest, in which a predetermined object is likely to be located, an expert system assigning a likelihood coefficient to one identified area of interest, computation means assigning a likelihood coefficient to at least one plotted area of interest, and computation means determining at least one relevant area of interest from the positions and likelihood coefficients assigned to areas of interest comprising at least one identified area of interest in which said object is likely to be located and/or at least one plotted area of interest on a set of images comprising at least one pilot image and/or at least one output image, said display means presenting at least one first relevant area of interest.

Abstract: A method includes estimating the position of the moving object on the basis of the reception of navigation signals emitted by a constellation of satellites, the navigation signals being modulated by a code and the receiver comprising a local replica of the code. The determination of the confidence indicator consists in estimating a speed of displacement of the receiver over an identified trajectory segment, deducing therefrom a Doppler delay function corresponding to the motion of the receiver, in correcting the auto-correlation function of the GNSS navigation signal received from each satellite of the constellation by means of the delay function, in comparing the corrected auto-correlation function with a theoretical auto-correlation function by applying a quadratic criterion corresponding to the confidence indicator.

Abstract: Guidance for an aircraft correcting a trajectory deviation due to wind computes a roll command during trajectory alignment according to imposed alignment passing through a determined point, via a current angular divergence between a line through the point and aircraft and direction of alignment and of a current estimated ground speed of the aircraft with respect to a frame of reference. The current estimated ground speed is computed via a current air speed and stored wind speed. The stored wind speed is obtained via at least one wind speed computed via a first value of a first speed equal to the speed of the said aircraft with respect to a frame of reference originating from a satellite navigation system and a second value of a second speed equal to the air speed. The first and second value are simultaneously accounted earlier than or at the instant at the alignment phase.

Abstract: The invention relates to a power supply system that is adapted be connected in input to N distinct power supply grids (R1, . . . , RN) delivering a direct or alternating input voltage (V1, VN) and to deliver a direct distribution voltage (VBUS), N being an integer greater than or equal to 2, of the type comprising a distribution bus operating under the distribution voltage (VBUS), N unidirectional converters (C1, . . . , CN) that can respectively be connected in input to a given power grid (R1, . . . , RN), and control means capable of controlling the unidirectional converters (C1, . . . CN). The power supply system also includes an energy storage device connected to the distribution bus and having a quantity of energy (E), and the control means are adapted to control the unidirectional converters (C1, . . . CN) simultaneously to regulate the electrical power (P1, . . . PN) delivered by each of said unidirectional converters (C1, . . . , CN) as a function of the quantity of energy (E).

Abstract: A communication method between two distinct networks with radio communication nodes, includes the following steps: collecting geographical location information for the nodes of the first and second network, deducing a geographical coverage area of the first and second network as a function of geographical location information; determining an intersection zone of the geographical coverage areas; identifying, as a function of the collected location information, nodes of the first and second network, located inside said intersection zone; and sending said nodes of the first identified network data indicating the collected geographical locations of the nodes of the second identified network.

Abstract: A power supply system with prioritized network selection is disclosed. In one aspect, the system can be connected to the output of N power supply networks (R1, . . . , RN), N being an integer greater than or equal to 2. It includes N controllable energy transfer members (T1, . . . , TN) each connected to a power supply network (R1, . . . , RN), control subsystem (14) for selecting one power supply network (R1, . . . , RN) by commanding the controllable member (T1, . . . , TN) connected to the selected power supply network (R1, . . . , RN) into a closed position, and energy storage subsystem capable of delivering a storage voltage (Ve). It may also comprise an energy converter connected to the output to the N controllable energy transfer members (T1, . . . , TN), the control subsystem being able to command the energy converter and the N controllable energy transfer members (T1, . . . , TN) to select at most one energy source from among the N power supply networks (R1, . . .