Patents by Inventor Thanh Huy Le
Thanh Huy Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200214840Abstract: A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.Type: ApplicationFiled: March 16, 2020Publication date: July 9, 2020Inventors: Kevin D. Rupp, Tung T. Le, Thanh Huy Le, Brian C. Gray, Alejandro J. Froimovich Rosenberg, Jeff Lindstrom, Kim D. Nguyen, Sonny Tran
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Patent number: 10639152Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for an implant, then return to a non-expanded state after the passage of the device. The sheath includes a foldable inner member having a detached flap structure at its distal tip that facilitates expansion of the sheath lumen to increased diameters, and an elastomeric distal end that reduces push and retrieval forces therethrough. The sheath can include a hemostasis seal on its proximal end to prevent the leakage of blood out of the sheath and prevent ballooning of outer layer of the sheath.Type: GrantFiled: June 18, 2018Date of Patent: May 5, 2020Assignee: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tung T. Le, Sovanpheap Mak, Alpana Kiran Gowdar, Richard D. White, Sonny Tran
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Patent number: 10624739Abstract: An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.Type: GrantFiled: December 6, 2017Date of Patent: April 21, 2020Assignee: Edwards Lifesciences CorporationInventors: Henry Bourang, Thanh Huy Le, David M. Taylor, Sam Sok, Mario M. Gabriel Iobbi, David J. Evans, Rajesh A. Khanna
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Publication number: 20200108231Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: ApplicationFiled: August 26, 2019Publication date: April 9, 2020Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana Kiran Gowdar, Yong Gao, David Delon Williams
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Patent number: 10588744Abstract: A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.Type: GrantFiled: August 30, 2016Date of Patent: March 17, 2020Assignee: Edwards Lifesciences CorporationInventors: Kevin D. Rupp, Tung T. Le, Thanh Huy Le, Brian C. Gray, Alejandro J. Froimovich Rosenberg, Jeff Lindstrom, Kim D. Nguyen, Sonny Tran
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Publication number: 20200060822Abstract: A method of delivery a prosthetic heart valve includes inserting a delivery apparatus and a prosthetic heart valve into a patient's vasculature. The delivery apparatus includes a steerable guide catheter, a balloon catheter, and a flex indicator. The balloon catheter extends coaxially through the guide catheter, the prosthetic heart valve is mounted on a distal end portion of the balloon catheter, and the flex indicator is movably coupled to a handle of the guide catheter. The method further includes adjusting flexion of a steerable section of the guide catheter to position the prosthetic heart valve. The flex indicator moves relative to the handle of the guide catheter as the flexion of the steerable section is adjusted, and the handle comprises one or more visual indicators adjacent the flex indicator to provide visual indication of an amount of flexion of the steerable section of the guide catheter.Type: ApplicationFiled: October 30, 2019Publication date: February 27, 2020Inventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes, Tram Ngoc Nguyen, Walter Lee
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Patent number: 10537431Abstract: An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.Type: GrantFiled: October 2, 2018Date of Patent: January 21, 2020Assignee: Edwards Lifesciences CorporationInventors: Pu Zhou, Yong Gao, Erik Bulman, Baigui Bian, Yidong M. Zhu, David D. Williams, Timothy A. Geiser, Michael G. Valdez, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar
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Publication number: 20190381284Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: ApplicationFiled: August 23, 2019Publication date: December 19, 2019Inventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana Kiran Gowdar, Yong Gao, David Delon Williams
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Patent number: 10500377Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: GrantFiled: October 2, 2018Date of Patent: December 10, 2019Assignee: Edwards Lifesciences CorporationInventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
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Patent number: 10478296Abstract: An apparatus for delivering a prosthetic heart valve includes a steerable guide catheter, a balloon catheter, and a flex indicator. The guide catheter has a handle and a guide tube extending from the handle. The guide tube has a distal end portion comprising a steerable section. The guide catheter further includes an adjustment mechanism on the handle and a pull wire connecting the adjustment mechanism to the steerable section for changing flexion of the steerable section. The balloon catheter includes a shaft extending coaxially through the guide tube. The shaft includes a proximal end portion and a distal end portion. The balloon catheter further includes a balloon mounted on the distal end portion of the shaft. The flex indicator moves relative to the handle upon adjustment of the adjustment mechanism. The handle includes visual indicia adjacent the flex indicator to provide visual indication of the flexion of the steerable section.Type: GrantFiled: November 20, 2018Date of Patent: November 19, 2019Assignee: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes
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Patent number: 10456253Abstract: A heart valve delivery apparatus includes a valve carrying member. A prosthetic valve is crimped onto the valve carrying member at a location that is distal or proximal to the balloon member, thereby providing a smaller profile delivery apparatus.Type: GrantFiled: June 10, 2015Date of Patent: October 29, 2019Assignee: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes
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Patent number: 10441419Abstract: A method of delivery a prosthetic heart valve includes inserting a delivery apparatus and a prosthetic heart valve into a patient's vasculature. The delivery apparatus includes a steerable guide catheter, a balloon catheter, and a flex indicator. The balloon catheter extends coaxially through the guide catheter, the prosthetic heart valve is mounted on a distal end portion of the balloon catheter, and the flex indicator is movably coupled to a handle of the guide catheter. The method further includes adjusting flexion of a steerable section of the guide catheter to position the prosthetic heart valve. The flex indicator moves relative to the handle of the guide catheter as the flexion of the steerable section is adjusted, and the handle comprises one or more visual indicators adjacent the flex indicator to provide visual indication of an amount of flexion of the steerable section of the guide catheter.Type: GrantFiled: November 20, 2018Date of Patent: October 15, 2019Assignee: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes
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Publication number: 20190298518Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location, and expanding the prosthetic heart valve and the expansion device from the compressed configuration to an expanded configuration. The expansion device includes an inner expandable member and a plurality of outer expandable members. The outer expandable members are distributed such that there are gaps providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.Type: ApplicationFiled: June 20, 2019Publication date: October 3, 2019Inventors: Gilbert Madrid, Matthew T. Winston, Sam Sok, Thanh Huy Le, Tri D. Tran, Kim Le, Michael D. Franklin
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Patent number: 10391281Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: GrantFiled: October 2, 2018Date of Patent: August 27, 2019Assignee: Edwards Lifesciences CorporationInventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
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Patent number: 10391279Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: GrantFiled: October 2, 2018Date of Patent: August 27, 2019Assignee: Edwards Lifesciences CorporationInventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
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Patent number: 10391280Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.Type: GrantFiled: October 2, 2018Date of Patent: August 27, 2019Assignee: Edwards Lifesciences CorporationInventors: Pu Zhou, Erik Bulman, Timothy A. Geiser, Michael G. Valdez, Yidong M. Zhu, Baigui Bian, Sonny Tran, Richard D. White, Thanh Huy Le, Tung T. Le, Alpana K. Gowdar, Yong Gao, David D. Williams
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Patent number: 10327897Abstract: A delivery system for stabilizing a catheter shaft across an aortic arch can include one or more stabilizing members configured to fix or stabilize the position of the catheter relative to the aortic arch of a patient.Type: GrantFiled: March 30, 2016Date of Patent: June 25, 2019Assignee: Edwards Lifesciences CorporationInventors: Gilbert Madrid, Matthew T. Winston, Sam Sok, Thanh Huy Le, Tri D. Tran, Kim Le, Michael D. Franklin
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Publication number: 20190105155Abstract: Disclosed embodiments of introducer devices provide hemostatic sealing and allow a delivery catheter to be inserted through the introducer seals without the use of a separate loader device that covers a medical device that is mounted on the catheter. Some disclosed introducers comprise a housing, a distal sheath extending distally from the housing and adapted to be inserted into a patient's vasculature, a distal hemostatic seal mounted within the housing and a proximal hemostatic seal mounted within the housing, and a slidable tube positioned within the housing that is movable longitudinally relative to the distal hemostatic seal between a proximal position and a distal position, wherein in the proximal position a distal end of the tube is positioned proximal to the distal hemostatic seal with the distal hemostatic seal closed, and wherein in the distal position the distal end of the tube extends through the distal hemostatic seal.Type: ApplicationFiled: December 3, 2018Publication date: April 11, 2019Inventors: Brian C. Gray, Tung T. Le, Andrew Oien, Sonny Tran, Thanh Huy Le, Robert Bowes, Maria L. Saravia, Uy D. Trinh, Hamid Rafi, Alejandro J. Froimovich Rosenberg
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Publication number: 20190083259Abstract: An apparatus for delivering a prosthetic heart valve includes a steerable guide catheter, a balloon catheter, and a flex indicator. The guide catheter has a handle and a guide tube extending from the handle. The guide tube has a distal end portion comprising a steerable section. The guide catheter further includes an adjustment mechanism on the handle and a pull wire connecting the adjustment mechanism to the steerable section for changing flexion of the steerable section. The balloon catheter includes a shaft extending coaxially through the guide tube. The shaft includes a proximal end portion and a distal end portion. The balloon catheter further includes a balloon mounted on the distal end portion of the shaft. The flex indicator moves relative to the handle upon adjustment of the adjustment mechanism. The handle includes visual indicia adjacent the flex indicator to provide visual indication of the flexion of the steerable section.Type: ApplicationFiled: November 20, 2018Publication date: March 21, 2019Applicant: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes
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Publication number: 20190083260Abstract: A method of delivery a prosthetic heart valve includes inserting a delivery apparatus and a prosthetic heart valve into a patient's vasculature. The delivery apparatus includes a steerable guide catheter, a balloon catheter, and a flex indicator. The balloon catheter extends coaxially through the guide catheter, the prosthetic heart valve is mounted on a distal end portion of the balloon catheter, and the flex indicator is movably coupled to a handle of the guide catheter. The method further includes adjusting flexion of a steerable section of the guide catheter to position the prosthetic heart valve. The flex indicator moves relative to the handle of the guide catheter as the flexion of the steerable section is adjusted, and the handle comprises one or more visual indicators adjacent the flex indicator to provide visual indication of an amount of flexion of the steerable section of the guide catheter.Type: ApplicationFiled: November 20, 2018Publication date: March 21, 2019Applicant: Edwards Lifesciences CorporationInventors: Thanh Huy Le, Tri D. Tran, Ronaldo C. Cayabyab, David M. Taylor, Antonio O. Vidal, Robert Bowes