Patents by Inventor Theodore R. Sana

Theodore R. Sana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8426573
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: April 23, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Publication number: 20120164147
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: March 7, 2012
    Publication date: June 28, 2012
    Applicant: SCHERING CORPORATION
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Patent number: 8148507
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: April 3, 2012
    Assignee: Schering Corporation
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Publication number: 20110165165
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: December 21, 2010
    Publication date: July 7, 2011
    Applicant: Schering Corporation
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Publication number: 20100104576
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: December 22, 2009
    Publication date: April 29, 2010
    Applicant: SCHERING CORPORATION
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Publication number: 20090155242
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: September 22, 2008
    Publication date: June 18, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Patent number: 7534561
    Abstract: Methods and devices for producing a nucleic acid arrays using in situ nucleic acid array synthesis protocols are provided. A feature of certain embodiments of the invention is that control probes are produced in collections of features, e.g., columns, of the arrays that have been selected according to a particular efficient control probe feature/column selection protocol. A feature of certain other embodiments of the invention is that an “all-bases-all-layers” probe set is produced in at least one of column of the arrays. Also provided are devices configured for use in the subject methods, as well as arrays produced using the subject methods and devices as well as methods for using such arrays.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: May 19, 2009
    Assignee: Agilent Technologies, Inc.
    Inventors: Theodore R. Sana, Eric M. Leproust, Michel G. M. Perbost, Paul K. Wolber
  • Patent number: 7504213
    Abstract: Methods and apparatus are disclosed for synthesizing a plurality of biopolymers at predetermined feature locations on a surface of a substrate. One or more of the feature locations comprises degenerate biopolymers. One or more biopolymer subunit precursors are added, in multiple rounds of subunit additions, at each of multiple feature locations on the surface to form the plurality of biopolymers on the surface. For each feature location comprising degenerate biopolymers, the biopolymer subunit precursors comprise a mixture of biopolymer subunit precursors for forming the degenerate biopolymers at the feature location.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: March 17, 2009
    Assignee: Agilent Technologies, Inc.
    Inventors: Theodore R. Sana, Eric M. Leproust, Paul K. Wolber
  • Patent number: 7205381
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1?, IL-1?, purified IL-1? and IL-1? proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: April 17, 2007
    Assignee: Schering Corporation
    Inventors: Joseph A. Hedrick, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Patent number: 7163792
    Abstract: The invention provides a composition, kit and method for hybridizing a probe and target at a temperature lower than their standard hybridization temperature. The chemical component added to the composition has a formula R(NH2)C?O, where R is amino or alkyl. A method for use of the chemical component and composition is also disclosed.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: January 16, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Theodore R. Sana, Paul K. Wolber, Clotilde S. Perbost
  • Patent number: 7132236
    Abstract: The invention provides a composition, kit and method for hybridizing a probe and target at a temperature lower than their standard hybridization temperature. The chemical component added to the composition has a formula R(NH2)C?O, where R is amino or alkyl. A method for use of the chemical component and composition is also disclosed.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: November 7, 2006
    Assignee: Agilent Technologies, Inc.
    Inventors: Theodore R. Sana, Paul K. Wolber, Clotilde S. Perbost
  • Patent number: 7078167
    Abstract: Nucleic acid arrays that have background features, and methods for using the same, are provided. The subject nucleic acid arrays include both hybridization features and background features, where the background features provide a background signal in a hybridization assay that is made up of a feature substrate component, a nucleic acid probe component and a nucleic acid probe non-specific binding component. In practicing the subject methods, the arrays are contacted with a sample and signals are observed for both hybridization features and background features. The background feature signal is then subtracted from the hybridization feature signal to obtain a background corrected hybridization feature signal that is employed as the output of the assay, e.g., to determine the presence, either qualitatively or quantitatively, of the analyte target nucleic acid in the sample. Also provided are kits for use in practicing the subject methods.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: July 18, 2006
    Assignee: Agilent Technologies, Inc.
    Inventors: Glenda C. Delenstarr, Paul K. Wolber, Theodore R. Sana
  • Publication number: 20040209262
    Abstract: Biopolymeric arrays, e.g., nucleic acid and peptide arrays, and methods for using the same are provided. A feature of the subject arrays is that they include test probes for two or more different species, where the species may have a known interaction, e.g., they may have a known parasite/host or pathogen/host relationship. Also provided are method of using the subject arrays, e.g., in assays where the interaction of two or more different species at the genomic and/or protein levels is evaluated. The subject arrays and methods of using the same find use in a variety of different applications.
    Type: Application
    Filed: April 21, 2003
    Publication date: October 21, 2004
    Inventors: Jay K. Bass, Theodore R. Sana, Sean J. Coughlan
  • Publication number: 20040197781
    Abstract: Methods and devices for producing a nucleic acid arrays using in situ nucleic acid array synthesis protocols are provided. A feature of certain embodiments of the invention is that control probes are produced in collections of features, e.g., columns, of the arrays that have been selected according to a particular efficient control probe feature/column selection protocol. A feature of certain other embodiments of the invention is that an “all-bases-all-layers” probe set is produced in at least one of column of the arrays. Also provided are devices configured for use in the subject methods, as well as arrays produced using the subject methods and devices as well as methods for using such arrays.
    Type: Application
    Filed: April 2, 2003
    Publication date: October 7, 2004
    Inventors: Theodore R. Sana, Eric M. Leproust, Michel G.M. Perbost, Paul K. Wolber
  • Publication number: 20030203391
    Abstract: The invention provides a composition, kit and method for hybridizing a probe and target at a temperature lower than their standard hybridization temperature. The chemical component added to the composition has a formula R(NH2)C═O, where R is amino or alkyl. A method for use of the chemical component and composition is also disclosed.
    Type: Application
    Filed: May 9, 2003
    Publication date: October 30, 2003
    Inventors: Theodore R. Sana, Paul K. Wolber, Clotilde S. Perbost
  • Publication number: 20030104396
    Abstract: The invention provides a composition, kit and method for hybridizing a probe and target at a temperature lower than their standard hybridization temperature. The chemical component added to the composition has a formula R(NH2)C═O, where R is amino or alkyl. A method for use of the chemical component and composition is also disclosed.
    Type: Application
    Filed: October 25, 2001
    Publication date: June 5, 2003
    Inventors: Theodore R. Sana, Paul K. Wolber, Clotilde S. Perbost
  • Publication number: 20030055218
    Abstract: Nucleic acids encoding mammalian, e.g., human receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: October 22, 2001
    Publication date: March 20, 2003
    Inventors: Jacqueline C. Timans, Johannes Eduard Maria Antonius Debets, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Publication number: 20020164332
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1&dgr;, IL-1&egr;, purified IL-1&dgr; and IL-1&egr; proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 7, 2002
    Inventors: Joseph A. Hedrick, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Publication number: 20020142292
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: September 7, 2001
    Publication date: October 3, 2002
    Inventors: Christi L. Parham, Daniel M. Gorman, Hirokazu Kurata, Naoko Arai, Theodore R. Sana, Jeanine D. Mattson, Erin E. Murphy, Chetan Savkoor, Jeffery Grein, Kathleen M. Smith, Terrill K. McClanahan
  • Publication number: 20020114806
    Abstract: Methods for treating, diagnosing, or evaluating mucosal surface medical conditions. Correlations of chemokine or receptor expression with gastrointestinal status are provided.
    Type: Application
    Filed: September 10, 2001
    Publication date: August 22, 2002
    Inventors: Annie Pardo-Semo, Moises Selman-Lama, Theodore R. Sana, Kathleen M. Smith, Robert L. Coffman, Albert Zlotnik