Patents by Inventor Theresa L. Johnson

Theresa L. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl compounds as IRAK inhibitors and uses thereof
    Patent number: 9790221
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: October 17, 2017
    Assignee: Merck Patent GmbH
    Inventors: Catherine Jorand-Lebrun, Reinaldo Jones, Annie Cho Won, Ngan Nguyen, Theresa L. Johnson, Lizbeth Celeste Deselm, Kausik Panda
  • COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
    Publication number: 20170283426
    Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 5, 2017
    Inventors: Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Ulrich GRAEDLER, Xuliang JIANG, Didier ROCHE, Hugues LEMOINE, Marine GILARDONE
  • COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
    Publication number: 20170283425
    Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 5, 2017
    Inventors: Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Ulrich GRAEDLER, Xuliang JIANG, Didier ROCHE, Hugues LEMOINE, Marine GILARDONE
  • COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
    Publication number: 20170283427
    Abstract: The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 5, 2017
    Inventors: Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Ulrich GRAEDLER, Xuliang JIANG, Santosh KULKARNI
  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20170275284
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20170217905
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 3, 2017
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Lizbeth C. DESELM, Hui QIU, Yufang XIAO, Constantin NEAGU, Igor MOCHALKIN, Theresa L. JOHNSON
  • Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
    Patent number: 9708324
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 18, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Henry Yu, Ruoxi Lan, Catherine Jorand-Lebrun, Theresa L. Johnson, Andreas Goutopoulos
  • Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4
    Patent number: 9708321
    Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: July 18, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Nadia Brugger, Brian L. Hodous, Amanda E. Sutton, Justin Potnick, Theresa L. Johnson, Thomas E. Richardson, Thomas Francis Nelson Haxell, James M. Dorsey, Robert James Foglesong
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 9662330
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: May 30, 2017
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth C. Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY
    Publication number: 20170136048
    Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Inventors: Brian L. HODOUS, Lesley LIU-BUJALSKI, Reinaldo JONES, Donald BANKSTON, Theresa L. JOHNSON, Igor MOCHALKIN, Ngan NGUYEN, Hui QIU, Andreas GOUTOPOULOS, Nadia BRUGGER
  • Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
    Patent number: 9580449
    Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: February 28, 2017
    Assignee: Merck Patent GmbH
    Inventors: Brian L. Hodous, Lesley Liu-Bujalski, Reinaldo Jones, Donald Bankston, Theresa L. Johnson, Igor Mochalkin, Ngan Nguyen, Hui Qiu, Andreas Goutopoulos, Nadia Brugger
  • AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES
    Publication number: 20160340323
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Ruoxi LAN, Justin POTNICK, Lizbeth Celeste DESELM, Mark W. CRONIN, JR., Constantin NEAGU, Xiaoling CHEN, Roch BOIVIN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160339028
    Abstract: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Ruoxi LAN, Lizbeth Celeste DE SELM, Constantin NEAGU, Justin POTNICK, Srinivasa R. KARRA, Theresa L. JOHNSON
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20160264548
    Abstract: The present invention relates to pyridine, pyrimidine, pyrazine, and pyridazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: October 21, 2014
    Publication date: September 15, 2016
    Applicant: Merck Patent GMBH
    Inventors: Hui QIU, Richard D. CALDWELL, Constantin NEAGU, Igor MOCHALKIN, Lesley LIU-BUJALSKI, Reinaldo JONES, Devon TATE, Theresa L. JOHNSON, Anna GARDBERG
  • Substituted pyrido[3,2-d]pyrimidines for treating cancer
    Patent number: 9440968
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 13, 2016
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Ruoxi Lan, Justin Potnick, Lizbeth Celeste Deselm, Mark W. Cronin, Jr., Constantin Neagu, Xiaoling Chen, Roch Boivin, Theresa L. Johnson, Andreas Goutopoulos
  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20160229856
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160184308
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 30, 2016
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Lizbeth C. DESELM, Hui QIU, Yufang XIAO, Constantin NEAGU, Igor MOCHALKIN, Theresa L. JOHNSON
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160145252
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Inventors: Catherine JORAND-LEBRUN, Reinaldo JONES, Annie Cho WON, Ngan NGUYEN, Theresa L. JOHNSON, Lizbeth Celeste DESELM, Kausik PANDA
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 9321760
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: April 26, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth Celeste Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
    Publication number: 20160096834
    Abstract: The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
    Type: Application
    Filed: October 6, 2015
    Publication date: April 7, 2016
    Inventors: Pascale GAILLARD, Jeyaprakashnarayanan SEENISAMY, Lesley LIU-BUJALSKI, Richard D. CALDWELL, Justin POTNICK, Hui QIU, Constantin NEAGU, Reinaldo JONES, Annie Cho WON, Andreas GOUTOPOULOS, Brian A. SHERER, Theresa L. JOHNSON, Anna GARDBERG