Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract: Compounds of formula (I) wherein X1, X2, W, R1 to R5, L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.

Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I), their manufacture, and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.

Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.

Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.

Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract: The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.

Abstract: An absorbent article, such as a sanitary napkin, that is for attaching to and wearing in an undergarment is provided. The sanitary napkin of the present invention has a fastener that aids the sanitary napkin in assuming a body-conforming configuration during wear. The fastener comprises at least two zones of fastener material located only in the end regions of the sanitary napkin. In one embodiment, the zones of fastener material are arranged in an overall configuration that resembles a modified letter "X" without any fastener material in the portion of the configuration that would form the center of the letter X, and the ends of the "X" located in the corner regions of the sanitary napkin.

Abstract: An absorbent article, such as a sanitary napkin is provided. The sanitary napkin of the present invention has a body-conforming configuration that is provided at least in part by a longitudinally-oriented resilient hump-forming element. The hump-forming element is positioned to form a hump along the longitudinal centerline on the body surface of the sanitary napkin. The sanitary napkin may also be provided with bending axes. The sanitary napkin may also be provided in a curved configuration.

Abstract: The present invention provides absorbent articles, especially sanitary napkins, containing a fluid transport layer. In-use, the transport layer directs menses to a storage layer, thereby minimizing product failure and staining of undergarments. The transport layer can protrude into, or through, a topsheet to provide very aggressive transport of vaginal discharges. Preferably, the transport layer is a layer of fibers having external capillary channels.

Abstract: Compositions comprise absorbent gelling materials combined with high levels of odor-controlling agents by means of binders. The preferred particle form of the compositions is easy to handle, and is used in the manufacture of catamenials, diapers, bandages, and the like. The absorbent gelling material enhances the odor-controlling properties of the compositions by helping to control ammonia odors.

Abstract: The present invention provides absorbent articles, especially sanitary napkins, containing a flow regulator positioned between the topsheet and the absorbent core. In-use, fluid deposited on the topsheet is internally moved in the longitudinal direction by the flow regulator before being released to the absorbent core. By moving substantial amounts of fluid in the longitudinal direction the flow regulator provides a more effective use of the absorbent core.