Patents by Inventor Theron Hermann
Theron Hermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11685938Abstract: The subject of this invention is improvements in the yield and titer of biological production of muconic acid by fermentation. Increased activity of one or more enzymes involved in the muconic acid pathway leads to increased production of muconic acid.Type: GrantFiled: May 21, 2021Date of Patent: June 27, 2023Assignee: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: Ryan Sillers, Theron Hermann, Michelle Spencer, Russell Udani, R. Rogers Yocum
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Patent number: 11447802Abstract: Yeast strains and fermentation process for producing D-lactic acid and L-lactic acid are disclosed with higher titer, higher yield, shorter time, lower pH, and higher average specific productivity.Type: GrantFiled: February 15, 2019Date of Patent: September 20, 2022Assignee: PTT Global Chemical Public Company LimitedInventors: Sudhanshu Vijay Dole, Theron Hermann, Sean Joseph Regan, Mark Andrew Sheff, Russell Lizardo Udani, R. Rogers Yocum
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Publication number: 20220090149Abstract: The present invention discloses a genetically engineered Kluyveromyces sp. yeast strain that is capable of producing lactic acid from carbon source selected from glucose, fructose, sucrose or a mixture thereof wherein the genetically engineered yeast comprises at least one heterologous DNA cassette that confers production of a protein functioning as a fructose importer. The genetically engineered yeast strain according to this invention has an improvement of fructose utilization and use fructose as a faster rate than conventional strain, allowing for shorter fermentation times and improved economics.Type: ApplicationFiled: December 23, 2019Publication date: March 24, 2022Applicant: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: Sudhanshu Vijay DOLE, Joel Stewart SCHMID, R. Rogers YOCUM, Theron HERMANN, Russell Lizardo UDANI, Sean Joseph REGAN, Mark Andrew SHEFF, Michelle SPENCER, Ryan SILLERS, Phatthanon PRASITCHOKE, Natthawut POOMSILA
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Publication number: 20210277429Abstract: The subject of this invention is improvements in the yield and titer of biological production of muconic acid by fermentation. Increased activity of one or more enzymes involved in the muconic acid pathway leads to increased production of muconic acid.Type: ApplicationFiled: May 21, 2021Publication date: September 9, 2021Applicant: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: Ryan SILLERS, Theron HERMANN, Michelle SPENCER, Russell UDANI, R. Rogers YOCUM
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Patent number: 10934565Abstract: This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose.Type: GrantFiled: September 30, 2019Date of Patent: March 2, 2021Assignee: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: R. Rogers Yocum, Andrew Christopher Collard, Theron Hermann, Xiaohui Yu, Wei Gong
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Publication number: 20210017551Abstract: Improved yeast strains and fermentation process for producing D-lactic acid and L-lactic acid are disclosed. The improvement lead to higher titer, higher yield, shorter time, lower pH, and higher average specific productivity.Type: ApplicationFiled: February 15, 2019Publication date: January 21, 2021Applicant: PTT Global Chemical Public Company LimitedInventors: Sudhanshu Vijay DOLE, Theron HERMANN, Sean Joseph REGAN, Mark SHEFF, Russell UDANI, R. Rogers YOCUM
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Publication number: 20200181658Abstract: The subject of this invention is improvements in the yield and titer of biological production of muconic acid by fermentation. Increased activity of one or more enzymes involved in the muconic acid pathway leads to increased production of muconic acid.Type: ApplicationFiled: March 1, 2017Publication date: June 11, 2020Applicant: PTT Global Chemical Public Company LimitedInventors: Ryan Sillers, Theron Hermann, Michelle Spencer, Russell Udani, R. Rogers Yocum
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Publication number: 20200131538Abstract: The invention provides processes for identifying and tracking genomic duplications that can occur during classical strain development or during the metabolic evolution of microbial strains originally constructed for the production of a biochemical through specific genetic manipulations, processes that stabilize the copy number of desirable genomic duplications using appropriate selectable markers, and non-naturally occurring microorganisms with stabilized copy numbers of a functional DNA sequence.Type: ApplicationFiled: June 29, 2018Publication date: April 30, 2020Applicant: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: R. Rogers YOCUM, Tammy GRABAR, Theron HERMANN, Christopher Joseph MARTIN, Ryan SILLERS, Xiaohui YU, Xiaomei ZHOU
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Publication number: 20200032301Abstract: This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose.Type: ApplicationFiled: September 30, 2019Publication date: January 30, 2020Applicant: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: R. Rogers YOCUM, Andrew Christopher COLLARD, Theron HERMANN, Xiaohui YU, Wei GONG
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Patent number: 10041094Abstract: The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.Type: GrantFiled: July 22, 2011Date of Patent: August 7, 2018Assignee: Myriant CorporationInventors: R. Rogers Yocum, Theron Hermann, Xiaohui Hu
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Patent number: 9957532Abstract: This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts. The improvements in the fermentation process involve providing a fermentation medium comprising an appropriate form of inorganic carbon, an appropriate amount of aeration and a biocatalyst with an enhanced ability to uptake and assimilate the inorganic carbon into the organic acids. This invention also provides, as a part of an integrated fermentation facility, a novel process for producing a solid source of inorganic carbon by sequestering carbon released from the fermentation in an alkali solution.Type: GrantFiled: May 1, 2015Date of Patent: May 1, 2018Assignee: Myriant CorporationInventors: Theron Hermann, James Reinhardt, Xiaohui Yu, Russell Udani, Lauren Staples
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Patent number: 9845513Abstract: This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains.Type: GrantFiled: December 13, 2011Date of Patent: December 19, 2017Assignee: Myriant CorporationInventors: Sudhandshu Dole, R. Rogers Yocum, Theron Hermann, Xiaohui Yu
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Publication number: 20160319309Abstract: This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts. The improvements in the fermentation process involve providing a fermentation medium comprising an appropriate form of inorganic carbon, an appropriate amount of aeration and a biocatalyst with an enhanced ability to uptake and assimilate the inorganic carbon into the organic acids. This invention also provides, as a part of an integrated fermentation facility, a novel process for producing a solid source of inorganic carbon by sequestering carbon released from the fermentation in an alkali solution.Type: ApplicationFiled: May 1, 2015Publication date: November 3, 2016Applicant: MYRIANT CORPORATIONInventors: Theron Hermann, James Reinhardt, Xiaohui YU, Russell Udani, Lauren Staples
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Publication number: 20160160245Abstract: This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose.Type: ApplicationFiled: July 22, 2014Publication date: June 9, 2016Applicant: MYRIANT CORPORATIONInventors: R. Rogers Yocum, Andrew Christopher Collard, Theron Hermann, Xiaohui Yu, Wei Gong
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Publication number: 20140234923Abstract: The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.Type: ApplicationFiled: July 22, 2011Publication date: August 21, 2014Applicant: MYRIANT CORPORATIONInventors: R. Rogers Yocum, Theron Hermann, Xiaohui Hu
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Publication number: 20130337519Abstract: This invention relates to the production of chemicals by fermentation with a microorganism in which the fermentation medium contains the sugar sucrose. As a specific example, succinic acid is produced from a sucrose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize sucrose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and/or a salt of succinic acid) at a commercial scale using feedstocks other than sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of sucrose into the parental strains.Type: ApplicationFiled: December 13, 2011Publication date: December 19, 2013Applicant: MYRIANT CORPORATIONInventors: Sudhandshu Dole, R. Rogers Yocum, Theron Hermann, Xiaohui Yu
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Publication number: 20130130339Abstract: This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts. The improvements in the fermentation process involve providing a fermentation medium comprising an appropriate form of inorganic carbon, an appropriate amount of aeration and a biocatalyst with an enhanced ability to uptake and assimilate the inorganic carbon into the organic acids. This invention also provides, as a part of an integrated fermentation facility, a novel process for producing a solid source of inorganic carbon by sequestering carbon released from the fermentation in an alkali solution.Type: ApplicationFiled: July 30, 2011Publication date: May 23, 2013Applicant: Myriant CorporationInventors: Theron Hermann, James Reinhardt, Xiaohui Yu, Russell Udani, Lauren Staples
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Patent number: 8232081Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ?-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured.Type: GrantFiled: November 8, 2004Date of Patent: July 31, 2012Assignee: BASF SEInventors: R. Rogers Yocum, Thomas A. Patterson, Theron Hermann, Janice G. Pero
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Patent number: 7989187Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: GrantFiled: July 3, 2003Date of Patent: August 2, 2011Assignee: BASF SEInventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Publication number: 20100009416Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.Type: ApplicationFiled: May 24, 2007Publication date: January 14, 2010Inventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice Pero, Rogers Yocum, Thomas Patterson, Mark Williams, Theron Hermann