Patents by Inventor Theron Hermann

Theron Hermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methionine producing recombinant microorganisms
    Publication number: 20090298136
    Abstract: This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
    Type: Application
    Filed: July 18, 2006
    Publication date: December 3, 2009
    Applicant: BASF AG
    Inventors: Oskar Zelder, Stefan Haefner, Corinna Klopprogge, Hartwig Schroder, Andrea Herold, Thomas A. Patterson, Theron Hermann, R. Rogers Yocum, Mark K. William, Janice G. Pero
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20080166777
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 16, 2007
    Publication date: July 10, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7291489
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: November 6, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7244593
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: July 17, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Roger Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Patent number: 7220561
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 19, 2002
    Date of Patent: May 22, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Roger Yocum, Kai-Uwe Baldenius, Christine Beck
  • Bacterial strains which overproduce riboflavin and methods of use thereof
    Patent number: 7091000
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: August 15, 2006
    Assignee: DSM Nutritional Products, Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20060141585
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 3, 2003
    Publication date: June 29, 2006
    Inventors: R Yocum, Thomas Patterson, Janice Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20060099692
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 3, 2002
    Publication date: May 11, 2006
    Inventors: R Yocum, Thomas Patterson, Janice Pero, Theron Hermann
  • Methods and microorganisms for production of panto-compounds
    Publication number: 20050089973
    Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ?-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured.
    Type: Application
    Filed: November 8, 2004
    Publication date: April 28, 2005
    Inventors: R. Yocum, Thomas Patterson, Theron Hermann, Janice Pero
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040146996
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 3, 2003
    Publication date: July 29, 2004
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040091979
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Inventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Publication number: 20040086982
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 6, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
    Publication number: 20040048343
    Abstract: The present invention features methods of producting 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (“HMBPA”) and &agr;-hydroxyisovalerate (“&agr;-HIV”) utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including &agr;-HIV.
    Type: Application
    Filed: July 18, 2003
    Publication date: March 11, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Bacterial strains which overproduce riboflavin
    Publication number: 20030232406
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Application
    Filed: February 10, 2003
    Publication date: December 18, 2003
    Applicant: ROCHE VITAMINS, INC.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Nutrient medium for bacterial strains which overproduce riboflavin
    Patent number: 6551813
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: April 22, 2003
    Assignee: Roche Vitamins Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Bacterial strains which overproduce riboflavin
    Patent number: 5925538
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: July 20, 1999
    Assignee: Roche Vitamins Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Process to produce lysocellin
    Patent number: 4033823
    Abstract: A fermentation process is disclosed wherein the known antibiotic lysocellin is produced by the fermentation of a new species of Streptomyces denominated as Streptomyces longwoodensis (X-14537).
    Type: Grant
    Filed: August 12, 1976
    Date of Patent: July 5, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, Norberto Palleroni, Theron Hermann, Barbara Prosser