Patents by Inventor Thierry Livache
Thierry Livache has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11953483Abstract: A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose.Type: GrantFiled: March 25, 2020Date of Patent: April 9, 2024Assignee: ARYBALLEInventors: Thierry Livache, Cyril Herrier, Romain Dubreuil
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Publication number: 20230012059Abstract: The present invention relates to a method for characterising, by means of an electronic nose, the release kinetics of odorous compounds from a sample, comprising the following series of steps: (a) supplying a sample; (b) at a time t1, exposing the sensor array of the electronic nose to some of the gaseous medium comprising the odorous compounds released from the sample, and processing the response emitted by the sensor array of the electronic nose, after said exposure, in the form of a signal; and (c) repeating step (b) at least once, at a time t2 different from the time t1, whereby an olfactory kinetic signature characterising the sample is obtained. The present invention also relates to the use of this method for anti-counterfeiting and/or quality control purposes and for generating a data bank or database of temporal olfactory signatures. The present invention finally relates to certain devices used when implementing such methods.Type: ApplicationFiled: December 15, 2020Publication date: January 12, 2023Inventors: Romain DUBREUIL, Cyril HERRIER, Thierry LIVACHE, Johanna DECORPS, Yann GUEGANNO
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Publication number: 20220252564Abstract: A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an ?-amino acid. The ?-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the ?-amino acid of the receptor of another sensor of the first series is hydrophobic, and the ?-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.Type: ApplicationFiled: July 8, 2020Publication date: August 11, 2022Inventors: Yanxia Hou-Broutin, Sophie BRENET, Arnaud BUHOT, Thierry LIVACHE, Cyril HERRIER, Tristan ROUSSELLE
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Patent number: 11402334Abstract: A photonic integrated circuit for an interferometric sensor includes a first waveguide called sensitive arm wherein a first portion of the light radiation is propagated, the sensitive arm being exposed to a first ambient medium and to at least one compound to be detected inducing a modification of the local refractive index perceived by the evanescent part of the electromagnetic field of the first portion of the light radiation, and a second waveguide called reference arm wherein a second portion of the light radiation is propagated, an encapsulation layer encapsulating the reference arm, the encapsulation layer being impermeable to the compound or compounds to be detected, so that the reference arm is exposed only to a second ambient medium, substantially of the same nature as the first ambient medium and without the compound to be detected and interferometric sensor comprising a photonic integrated circuit according to the invention.Type: GrantFiled: June 16, 2020Date of Patent: August 2, 2022Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, ARYBALLEInventors: Loïc Laplatine, Mathieu Dupoy, Maryse Fournier, Pierre Labeye, Thierry Livache, Cyril Herrier
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Publication number: 20220187263Abstract: A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose.Type: ApplicationFiled: March 25, 2020Publication date: June 16, 2022Inventors: Thierry LIVACHE, Cyril HERRIER, Romain DUBREUIL
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Patent number: 11287377Abstract: The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, the detection system comprises a plurality of cross-reactivity detection sensors (D1, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that the detection system further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. The detection system further relates to an electronic nose comprising such a detection system.Type: GrantFiled: September 11, 2018Date of Patent: March 29, 2022Assignees: ARYBALLE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITÉ GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Yanxia Hou-Broutin, Sophie Brenet, Thierry Livache, Cyril Herrier, Tristan Rousselle
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Patent number: 11085921Abstract: The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.Type: GrantFiled: February 21, 2013Date of Patent: August 10, 2021Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherche Scientifique, Universite Paris-SudInventors: Thierry Livache, Arnaud Buhot, David Bonnaffe, Yanxia Hou-Broutin
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Patent number: 10983049Abstract: The invention relates to a method for detecting a local change in refractive index of a dielectric medium located on the surface of an optical sensor, said optical sensor comprising for this purpose a waveguide comprising a region, called the active region, covered with at least one metallic layer in contact with the dielectric medium, said method comprising the following steps: a) emitting a light beam at the input of the waveguide so that this light beam can be propagated, within the waveguide, according to at least N propagation modes, where N is a natural integer such that N?2; b) measuring the intensity of at least one zone of the spatial distribution of the intensity of the light beam reflected by said active region of the optical sensor; and c) detecting the local change in the refractive index of the dielectric medium by means of a database supplying the link between the intensity of said at least one zone of the spatial distribution of the intensity of the light beam reflected by the active region oType: GrantFiled: February 15, 2018Date of Patent: April 20, 2021Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Karim Vindas, Elodie Engel, Loic Leroy, Thierry Livache, Arnaud Buhot
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Patent number: 10928369Abstract: The invention relates to a method for calibrating an electronic nose, said electronic nose comprising a plurality of optical sensors arranged on a surface and capable of being in contact with a gaseous medium of interest, said optical sensors being capable of delivering a signal representative of the local optical index of the gaseous medium of interest when they are excited by photons, the method being characterized in that it comprises the following steps: after having placed the electronic nose in a gaseous medium of interest at the initial pressure (P0) and the initial temperature (T0): a) sending photons in the direction of the sensors so as to excite said sensors; b) measuring the signal delivered by each of the sensors, this measurement providing as many responses as there are sensors; c) modifying the pressure and/or temperature of the gaseous medium of interest; d) repeating step b); and e) for each sensor, determining a correction factor such as a variation in the signal between steps d) and b) corrType: GrantFiled: March 2, 2018Date of Patent: February 23, 2021Assignees: ARYBALLE TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT A L'ENERGIE ATOMIQUE, UNIVERSITE GRENOBLE ALPESInventors: Cyril Herrier, Yanxia Hou-Broutin, Francois-Xavier Gallat, Thierry Livache, Tristan Rousselle
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Publication number: 20200400883Abstract: A photonic integrated circuit for an interferometric sensor includes a first waveguide called sensitive arm wherein a first portion of the light radiation is propagated, the sensitive arm being exposed to a first ambient medium and to at least one compound to be detected inducing a modification of the local refractive index perceived by the evanescent part of the electromagnetic field of the first portion of the light radiation, and a second waveguide called reference arm wherein a second portion of the light radiation is propagated, an encapsulation layer encapsulating the reference arm, the encapsulation layer being impermeable to the compound or compounds to be detected, so that the reference arm is exposed only to a second ambient medium, substantially of the same nature as the first ambient medium and without the compound to be detected and interferometric sensor comprising a photonic integrated circuit according to the invention.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Inventors: Loïc LAPLATINE, Mathieu DUPOY, Maryse FOURNIER, Pierre LABEYE, Thierry LIVACHE, Cyril HERRIER
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Publication number: 20200256793Abstract: The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, which detection system comprises a plurality of cross-reactivity detection sensors (D1, D2, D3, D4, D5, D6, D7) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that it further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. It further relates to an electronic nose comprising such a detection system.Type: ApplicationFiled: September 11, 2018Publication date: August 13, 2020Inventors: Yanxia HOU-BROUTIN, Sophie BRENET, Thierry LIVACHE, Cyril HERRIER, Tristan ROUSSELLE
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Publication number: 20200088702Abstract: The invention relates to a method for calibrating an electronic nose, said electronic nose comprising a plurality of optical sensors arranged on a surface and capable of being in contact with a gaseous medium of interest, said optical sensors being capable of delivering a signal representative of the local optical index of the gaseous medium of interest when they are excited by photons, the method being characterized in that it comprises the following steps: after having placed the electronic nose in a gaseous medium of interest at the initial pressure (P0) and the initial temperature (T0): a) sending photons in the direction of the sensors so as to excite said sensors; b) measuring the signal delivered by each of the sensors, this measurement providing as many responses as there are sensors; c) modifying the pressure and/or temperature of the gaseous medium of interest; d) repeating step b); and e) for each sensor, determining a correction factor such as a variation in the signal between steps d) and b) corrType: ApplicationFiled: March 2, 2018Publication date: March 19, 2020Inventors: Cyril HERRIER, Yanxia HOU-BROUTIN, Francois-Xavier GALLAT, Thierry LIVACHE, Tristan ROUSSELLE
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Patent number: 10457908Abstract: The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.Type: GrantFiled: April 3, 2015Date of Patent: October 29, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, PRESTODIAG, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Roberto Calemczuk, David Carrara, Thierry Livache, Thibaut Mercey, Félix Piat, Yoann Roupioz, Sami Slimani
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Publication number: 20180231462Abstract: The invention relates to a method for detecting a local change in refractive index of a dielectric medium located on the surface of an optical sensor, said optical sensor comprising for this purpose a waveguide comprising a region, called the active region, covered with at least one metallic layer in contact with the dielectric medium, said method comprising the following steps: a) emitting a light beam at the input of the waveguide so that this light beam can be propagated, within the waveguide, according to at least N propagation modes, where N is a natural integer such that N?2; b) measuring the intensity of at least one zone of the spatial distribution of the intensity of the light beam reflected by said active region of the optical sensor; and c) detecting the local change in the refractive index of the dielectric medium by means of a database supplying the link between the intensity of said at least one zone of the spatial distribution of the intensity of the light beam reflected by the active region oType: ApplicationFiled: February 15, 2018Publication date: August 16, 2018Inventors: Karim VINDAS, Elodie ENGEL, Loic LEROY, Thierry LIVACHE, Arnaud BUHOT
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Publication number: 20180045711Abstract: A method for measuring in real time a secretion of a compound by a target, and a device implementing the method, the method including: culturing, in a liquid medium, in a culture chamber, a plurality of targets including at least one target, the culture chamber including: (i) at least one 1st surface on which the target is present, presence of the target generating a 1st signal; and (ii) at least one 2nd surface that is different from the 1st surface and not coplanar with the 1st surface, which surface is functionalized by at least one ligand specifically binding to the compound secreted by the target, the specific bond between the ligand and the compound generating a 2nd signal that is distinct from the 1st signal; and detecting in real time the 2nd signal and optionally the 1st signal.Type: ApplicationFiled: March 4, 2016Publication date: February 15, 2018Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Yoann ROUPIOZ, Loic LEROY, Patrice MARCHE, Olivier DELLEA, Myriam CUBIZOLLES, Cyril HERRIER, Thierry LIVACHE
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Patent number: 9841429Abstract: The present invention relates to a method for real-time measurement of the secretion of at least one compound by at least one individual cell, comprising: the culturing, in a liquid medium, of at least one cell in a culture chamber, at least one wall of which comprises at least one sensitive area, a sensitive area comprising a plurality of ligands, attached to a solid support, each ligand being able to bind specifically to the compound, and an element for real-time transduction of a signal produced by the binding of the compound to one of the ligands; the identification, in a sensitive area, of at least one spot producing a signal; the real-time measurement of the signal produced by the spot identified, representing the amount of compound secreted by an individual cell.Type: GrantFiled: November 30, 2012Date of Patent: December 12, 2017Assignees: COMMISSARIANT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Thierry Livache, Yoann Roupioz, Sarah Milgram, Bernard Maillere, Patrice Marche
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Publication number: 20170022470Abstract: The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.Type: ApplicationFiled: April 3, 2015Publication date: January 26, 2017Inventors: Roberto CALEMCZUK, David CARRARA, Thierry LIVACHE, Thibaut MERCEY, Félix PIAT, Yoann ROUPIOZ, Sami SLIMANI
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Patent number: 9011939Abstract: The present invention relates to polysaccharides selected from sulphated arabinogalactans, apiogalacturonans and sulphated heteroglycans intended to be used as a drug for the preventive or curative treatment of an influenza virus, as well as to the pharmaceutical compositions including, in particular in combination with at least one pharmaceutically acceptable carrier: either an extract of Codium fragile, including sulphated arabinogalactans, or an extract of Zostera marina or Lemna minor, including apiogalacturonans, or an extract of Caulerpa racemosa, including sulphated heteroglycans.Type: GrantFiled: January 3, 2012Date of Patent: April 21, 2015Assignees: Elicityl, Centre National de la Recherche Scientifique, Insititut National de la Sante et de la Recherche Medicale—I.N.S.E.R.M., Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA)Inventors: Bruno Lina, Olivier Ferraris, Ho Hong Hai Vo, François-Loïc Cosset, Judit Szecsi, Alain Heyraud, Hugues Lortat-Jacob, Julia Bartoli, Rabia Sadir, Thierry Livache, Benoît Darblade, Stéphane Havet, Silvère Bonnet
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Publication number: 20150037909Abstract: The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.Type: ApplicationFiled: February 21, 2013Publication date: February 5, 2015Applicants: Centre National de la Recherche Scientifique, UNIVERSITE PARIS-SUD, Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Thierry Livache, Arnaud Buhot, David Bonnaffe, Yanxia Hou-Broutin
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Publication number: 20140023675Abstract: The present invention relates to polysaccharides selected from sulphated arabinogalactans, apiogalacturonans and sulphated heteroglycans intended to be used as a drug for the preventive or curative treatment of an influenza virus, as well as to the pharmaceutical compositions including, in particular in combination with at least one pharmaceutically acceptable carrier: either an extract of Codium fragile, including sulphated arabinogalactans, or an extract of Zostera marina or Lemna minor, including apiogalacturonans, or an extract of Caulerpa racemosa, including sulphated heteroglycans.Type: ApplicationFiled: January 3, 2012Publication date: January 23, 2014Applicants: Elicityl, Commissariat A L'Energie Atomique Et Aux Energies Alternatives (CEA), Institut National De La Sante Et De La Recherche Medicale - I.N.S.E.R.M., Centre National De La Recherche ScientifiqueInventors: Bruno Lina, Olivier Ferraris, Ho Hong Hai Vo, Francois-Loic Cosset, Judit Szecsi, Alain Heyraud, Hugues Lortat-Jacob, Julia Bartoli, Rabia Sadir, Thierry Livache, Benoit Darblade, Stephane Havet, Silvére Bonnet