Patents by Inventor Thierry ROISNEL

Thierry ROISNEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL HARRINGTONINES SALTS IN THE CRYSTALLINE STATE, THEIR USE FOR THE PURIFICATION OF THE CORRESPONDING DRUG SUBSTANCE AND AS CHEMOTHERAPEUTIC AGENTS GIVEN ALONE OR COMBINED WITH RADIOTHERAPY OR AS IMMUNOMODULATING AGENTS
    Publication number: 20190161493
    Abstract: The present invention concerns harringtonines salts never described in the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general formula 1, comprising solvates, made by reacting a cephalotaxine ester alkaloid base having formula 2, in which R1 is, but not limited to, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, and R2 is, independently, but not limited to H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, with an acid having general formula AH in a non-aqueous crystallization solvent, wherein said salt has a large water solubility. The invention also relates to a process for preparing and purifying these salts and their use as chemostherapeutic drugs, alone or combined with radiotherapy, or as immunomodulating agents.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 30, 2019
    Inventors: Jean-Pierre ROBIN, Nina RADOSEVIC, Julie BLANCHARD, Thierry ROISNEL, Thierry BATAILLE
  • Harringtonines salts in the crystalline state and their use for the purification of the corresponding drug substance
    Patent number: 10150776
    Abstract: The present disclosure concerns harringtonines salts at the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general formula 1, comprising solvates, made by reacting a cephalotaxine ester alkaloid base having formula 2, in which R1 is, but not limited to, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, and R2 is, independently, but not limited to H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, with an acid having general formula AH in a non-aqueous crystallization solvent, wherein the said salt has a large water solubility. The disclosure is also related to a process for preparing and purifying these salts and their use as chemotherapeutic drugs.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: December 11, 2018
    Inventors: Jean-Pierre Robin, Nina Radosevic, Julie Blanchard, Thierry Roisnel, Thierry Bataille
  • HARRINGTONINES SALTS IN THE CRYSTALLINE STATE AND THEIR USE FOR THE PURIFICATION OF THE CORRESPONDING DRUG SUBSTANCE
    Publication number: 20160333023
    Abstract: The present disclosure concerns harringtonines salts at the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and having general formula 1, comprising solvates, made by reacting a cephalotaxine ester alkaloid base having formula 2, in which R1 is, but not limited to, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, and R2 is, independently, but not limited to H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, with an acid having general formula AH in a non-aqueous crystallization solvent, wherein the said salt has a large water solubility. The disclosure is also related to a process for preparing and purifying these salts and their use as chemotherapeutic drugs.
    Type: Application
    Filed: December 30, 2014
    Publication date: November 17, 2016
    Inventors: Jean-Pierre ROBIN, Nina RADOSEVIC, Julie BLANCHARD, Thierry ROISNEL, Thierry BATAILLE