Abstract: A recipient has a body designed to contain a fluid and an orifice by which the fluid may be introduced into the body. The recipient is equipped with a system for the sterile transfer of the fluid from inside the body. The transfer system comprises a deformable and impervious wall, wherein the wall is positioned with respect to the recipient so that it forms a closed and sterile space inside which the orifice is located, a fluid communication device between the closed space and the outside of the recipient, wherein the device may be handled without compromising the sterility, and a seal structure associated with the orifice, wherein the seal structure is at least partially located inside the closed space so that it may be moved between an open position and a closed position of the orifice.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.

Abstract: One aspect of the disclosure relates to a filtration unit intended to allow the removal of leukocytes from a fluid such as blood or a blood component, the unit containing a porous element including a medium for the removal of leukocytes by adsorption and filtration of the leukocytes, said medium including a number of layers of one and the same type which are formed from at least one porous non-woven material, in which at least one layer has been pressed by calendering prior to the stacking thereof, said at least one calendered layer being disposed on the downstream side of the stack, while the medium includes at least one non-calendered layer. The invention also relates to a bag-based system including such a unit, said system being in particular arranged for the sterile and closed-circuit filtration of the fluid.

Abstract: The invention includes a filtration unit for the selective deleukocytation of a fluid containing blood platelets such as blood or a blood component. The unit includes a medium for deleukocytation by adsorption and/or filtration of the leukocytes. The medium is formed by at least one layer of non-woven polyurethane fabric which has been treated by gas plasma. The invention also includes bag systems containing such a unit, including closed filtration systems.

Abstract: A filtering unit, which may be used to filter blood or blood components to remove leukocytes. The filtering unit includes a rigid outer casing connected to a filter medium by an impermeable association means to define two compartments. The association means may be flexible and may be disposed around the filter medium. The filtering unit may additionally include a pre-filter and a post-filter.

Abstract: The disclosure includes a flexible bag (1) intended to receive a biological fluid with a view to its centrifugation. The bag includes an external enclosure (2) formed by two sheets of flexible plastic (3, 3?) connected at their periphery (4) so as to define an internal volume (5) for the fluid. The external enclosure (2) is provided with at least one inlet (6) and/or outlet (7) orifice for the fluid. The bag (1) also includes means (8) for the temporary association of at least one component with the bag (1). The means (8) is disposed on the external enclosure (2), in which the temporary association means are assembled on the bag (1) on a part of the periphery (4) of the enclosure (2) and are arranged to allow the insertion of the component between the means (8) and the enclosure (2) so as to provide temporary association during the centrifugation of the bag (1).

Abstract: The invention relates to a method and apparatus for the automatic handling of bag systems in an installation. The method includes the steps of loading at least one bag system having a primary bag containing a body fluid such as blood and a secondary bag into a handling device, wherein the bag system is placed in a position such that no filtering of the body fluid takes place; automatically actuating the handling device so that the bag system is moved to a position wherein filtering occurs; and unloading the bag system from in the handling device when all the filtrate is received in the secondary bag.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The invention concerns a bag system for collecting a biological fluid the system intended for use in a collection machine including a peristaltic pump, the system including, in closed circuit, a fluid collection device, a solution bag containing an anticoagulant and/or preservation solution, and a collection bag intended to receive the fluid collected with the anticoagulant and/or preservation solution added. The collection bag is in fluid communication with the collection device by way of a first tube provided with a connector and with the solution bag by way of a second tube connected to the connector. A device for associating the first and second tubes is provided to allow, between the connector and the association device, the formation of a loop with the second tube, the conformation of the loop being arranged to enable it to be disposed around at least part of a head of a peristaltic pump.

Abstract: The invention concerns a method of collecting a biological fluid, in particular blood, with an anticoagulant and/or preservation solution added, in which the biological fluid is collected by natural flow and the anticoagulant and/or preservation solution is added by pumping, the method making provision for measuring the flow of fluid collected and slaving the pumping speed to the measured flow, so as to obtain continuously during collection a given ratio between the quantity of fluid collected and the quantity of anticoagulant and/or preservation solution added. The invention also concerns a collection machine and bag system for implementing the method.

Abstract: The invention includes an assembly including a package and a bag system for collecting a biological fluid, in particular blood. The system may be confined in a sterile fashion in the package. The system may include a fluid collecting bag and a device for sampling the fluid to be collected which includes at least one sampling receptacle associated dissociably with the system. The collecting bag and the sampling receptacle are each provided with an identification tag which includes information making it possible, after dissociation of the receptacle from the bag system, to unequivocally establish that the sampling receptacle and the collecting bag come from the same bag system.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: The invention includes a filtration unit for the selective deleukocytation of a fluid containing blood platelets such as blood or a blood component. The unit includes a medium for deleukocytation by adsorption and/or filtration of the leukocytes. The medium is formed by at least one layer of non-woven polyurethane fabric which has been treated by gas plasma.

Abstract: The invention concerns a method for automatic handling of bag systems (3) in an installation and said installation. The method comprises steps which consist in: loading at least a bag system (3) in a handling device (2), said bag system (3) being in a position such that no filtering of the fluid will take place; automatically actuating the handling device (2) so that the bag system (3) is handled to a position wherein filtering occurs; unloading the bag system (3) present in the handling device (2) when all the filtrate is received in the secondary bag (36).

Abstract: The present invention is directed to a filtration unit intended to allow the removal of leukocytes from a fluid such as blood or a blood component. The filtration unit contains a porous element comprising a medium for the removal of leukocytes by adsorption and filtration of the leukocytes. The medium comprises a number of layers of a first type which are formed from at least one porous non-woven material. At least one layer has been pressed by calendering prior to the stacking thereof. The at least one calendered layer is disposed on the downstream side of the stack. The medium also comprises at least one non-calendered layer. The present invention is also directed to a bag-based system comprising the filtration unit. The system is in particular arranged for the sterile and closed-circuit filtration of the fluid.

Abstract: The invention concerns a collection bag (1) for a fluid, in particular whole blood, comprising an outer envelope (2) formed with two sheets of flexible plastic material (3, 4) assembled on their periphery so as to define an inner volume, said outer envelope (2) being provided with at least an orifice designed to enable the fluid to be supplied and dispensed, wherein at least one insert (15) is fixed in the internal volume of the bag (1) to define at least two sub-volumes (16, 17) in the internal volume, said insert (15) being arranged to form a partial obstruction to the flow of the fluid inside said internal volume leaving at least a passage for the fluid (19, 20, 22, 24) between said two sub-volumes (16, 17).

Abstract: An extraction device for a biological fluid with an additive solution in which it is desirable for the additive solution to be present in a particular volume proportion to the biological fluid. The volume proportion of the additive solution is determined by the ratio of cross sections of two tubes, one which supplies the biological fluid to a collecting bag and a second which supplies the additive solution to a collecting bag. The tubes are periodically constricted in constriction areas by a pump. The tubes are configured so that the additive solution and the biological fluid only mix downstream of the constriction areas, thereby reducing the risk of supplying the additive solution to the source of the biological fluid. In an exemplary embodiment the biological fluid is blood collected from a patient or donor and the additive solution is an anticoagulant and/or preservation solution.