Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

Abstract: A secure short-distance-based communication and validation system validates users in a validation area. The system may include multiple zones in the validation area and beacons in each zone. A run-time mobile device identifier and keys that may be location-specific, device-specific and time-specific are generated and utilized for secure communication between mobile devices and a zone computer in a zone. The validation area may be in a vehicle, and validation may include deducting a fare.

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

Abstract: A secure short-distance-based communication and enforcement system validates users in a validation and enforcement area and can check if users in the validation and enforcement area have been validated. A visual object can be displayed on an enforcement computer and a mobile device of a user in the in the validation and enforcement area to determine if a user is validated. The visual object may be periodically changed.

Abstract: A secure short-distance-based communication and enforcement system validates users in a validation and enforcement area and can check if users in the validation and enforcement area have been validated. Run-time IDs and keys that may be location-specific and device-specific may be generated and utilized for secure communication between mobile devices and zone computers and enforcement computers that execute validation and inspection.

Abstract: A secure short-distance-based communication and validation system validates users in a validation area. The system may include multiple zones in the validation area and beacons in each zone. A run-time mobile device identifier and keys that may be location-specific, device-specific and time-specific are generated and utilized for secure communication between mobile devices and a zone computer in a zone. The validation area may be in a vehicle, and validation may include deducting a fare.

Abstract: A secure short-distance-based communication and validation system validates users in a validation area. The system may include multiple zones in the validation area and beacons in each zone. A run-time mobile device identifier and keys that may be location-specific, device-specific and time-specific are generated and utilized for secure communication between mobile devices and a zone computer in a zone. The validation area may be in a vehicle, and validation may include deducting a fare.

Abstract: Systems, devices, and methods for providing a swinging system and platform assembly that deploys a swim platform from the front of a pontoon boat which is mounted underneath the deck between the pontoons in a raised position adjacent to the underside of the pontoon deck. The platform assembly, when deployed, provides a safe method for users of pontoon boat vessels to access the front deck area from land or from a body of water. The platform deploys from two pivoting frames affixed to the bottom of the deck, which is powered by an actuator with the push of a button on the control panel. For deployment, the platform is both lowered and extended out from the pontoon boat. A powered actuator positions the platform in the deployed position for use and then retracts the platform for storage.

Abstract: An access control system controls access to a restricted area. A mobile device exchanges messages with a backend server to validate a user and to control an actuator for a physical barrier responsive to validation. Beacon-based unique identifiers are calculated at validation time for the current location to facilitate the validation.

Abstract: A secure short-distance-based communication and access control system controls access to a restricted area. A run-time mobile device identifier and keys that may be location-specific, device-specific and time-specific are generated and utilized for secure communication between mobile devices and zone computers. The zone computers can validate users via their mobile devices to allow or deny access to the restricted area.

Abstract: The invention is for a sanitary container to receive and at least temporarily store waste. The container has a hollow housing with an upper aperture, and a portion of the housing can open and reveal the hollow interior. There is an upper part, located substantially above the housing to act as a lid, and this can move to open and close the upper aperture. There is an endless cassette non-rotationally mounted at or near the upper aperture, which holds a length of shirred plastics tubing which exits the cassette at or near its top and which can flow down through a central aperture of the endless cassette toward a bottom of the housing to form a containment. The containment can then receive waste from the upper aperture when open by the lid. The containment can be accessed by the portion when open, and the containment can be drawn downwardly to form a new containment replenished from the cassette and sealed closed by the sealer unit, and allows removal of the containment.

Abstract: A secure short-distance-based communication and enforcement system validates users in a validation and enforcement area and can check if users in the validation and enforcement area have been validated. A visual object can be displayed on an enforcement computer and a mobile device of a user in the in the validation and enforcement area to determine if a user is validated. The visual object may be periodically changed.

Abstract: A secure short-distance-based communication and enforcement system validates users in a validation and enforcement area and can check if users in the validation and enforcement area have been validated. Run-time IDs and keys that may be location-specific and device-specific may be generated and utilized for secure communication between mobile devices and zone computers and enforcement computers that execute validation and inspection.

Abstract: An access control system controls access to a restricted area. A mobile device exchanges messages with a backend server to validate a user and to control an actuator for a physical barrier responsive to validation. Beacon-based unique identifiers are calculated at validation time for the current location to facilitate the validation.

Abstract: A secure short-distance-based communication and validation system validates users in a validation area. The system may include multiple zones in the validation area and beacons in each zone. A run-time mobile device identifier and keys that may be location-specific, device-specific and time-specific are generated and utilized for secure communication between mobile devices and a zone computer in a zone. The validation area may be in a vehicle, and validation may include deducting a fare.

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.