Abstract: Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract: A cylindrical waveguide (1) used for analyzing a flowing stream of corn masa (18) using a guided microwave spectroscopy (GMS) process. The waveguide (1) includes opposed spaced apart plates (2, 5) that each define a plane within the waveguide housing (3) that is parallel to the direction (47) of corn masa flow through the waveguide. The housing (1) includes two opposed frames (7, 19) that each surround an aperture (6) that permits access to the region between the waveguide plates (2, 5). A microwave probe assembly (81) is mounted at each frame (7, 19) to permit the radiation and reception of electromagnetic waves within the housing (1) as required to perform the GMS process. A temperature probe (51) is inserted into the interior of the housing (1) at a fitting (13). In an actual installation a y-shaped assembly (89) can be used to divide the corn masa flow into two separate paths with one path containing the waveguide (1).

Abstract: A waste disposal receptacle (1) including a body (20) and a lid (30). Wherein the body (20) is defined by a base (21), at least one side (22) and an open top (23); and the lid (30) is defined by at least one side (31), a top (32) and an open base and includes an aperture (35) in the at least one side (31) through which material can be deposited into the receptacle (1); Wherein the at least one side (31) of the lid (30) is adapted to be received within the body (20) and is reversibly movable between an open and closed position such that when the lid (30) is in the closed position, the aperture (35) is covered by the at least one side (22) of the body (20) and when the lid (30) is in the open position, the aperture (35) is exposed.

Abstract: Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract: Disclosed are apparatus and methodology for providing an improved pick-resistant lock structure. Contact edges associated with individual combination and driver pins are moved away from the true shear lines to deny a lock picker the ability to feel any contact between a selected pin and a pin hole edge. Methodologies and apparatus are also provided to prevent a lock picker from obtaining an impression of the lock shear plane.

Abstract: The outlet pressure of a pump that fluctuates rapidly, as is typical of high pressure multiplex pumps, is sensed in a pressure line leading from the main flow line to a damping mechanism. The damping mechanism comprises a pair of small spaced openings, which are preferably adjustable in size. The damping mechanism is ideally a pair of needle valves placed in series so the pressure downstream of the second needle valve fluctuates considerably less than upstream of the first needle valve. The damped pressure is sensed to provide an input to real time graphs showing various pertinent pressure measurements involving the application of pressure, e.g. to monitor downhole tools in hydrocarbon wells. The downhole tools may be fluid driven motors, whipstocks, packers, wiper plugs and the like. In the case of fluid driven or mud motors, a base line pressure taken when the motor is idling is compared to the pressure when the motor is drilling to detect the onset of motor stall.

Abstract: The present invention is a method for making a plastic overcap using a mold tool stack. The mold tool stack has a core and a cavity plate forming a cavity therebetween. The core has a resin passageway therein with a gate in a top surface of the core. The gate has a valve proximate the top surface of the core to regulate resin flowing from the resin passageway and into the cavity. The steps of the mold method are as follows: the mold tool stack is closed to form the cavity; the valve is opened to allow resin to enter the cavity; the valve is closed; the resin is allowed to cool; and the mold tool stack is opened to allow removal of the plastic overcap from within the mold tool stack. The top side of the plastic overcap produced is blemish-free, facilitating placement of labels and other markings thereon.

Abstract: A method and apparatus for milling a desired pocket in a solid workpiece uses an abrasive fluid-jet by moving and suitably orienting the abrasive fluid-jet relative to the workpiece. The method includes defining a path of the abrasive fluid-jet necessary to mill a desired pocket in the solid workpiece. The path is defined by a number of parameters. The parameters include a translation velocity, a fluid pressure, and an abrasive fluid-jet position and orientation relative to the workpiece. Generating a command set is according to the defined path and is configured to drive a computer numerical control manipulator system.

Abstract: A nozzle apparatus and method of use for extruding a conductive paste through a stencil or screen onto a substrate are disclosed. The nozzle includes a body and a conformable insert for contacting the screen. The method comprises the steps of obtaining a substrate and a patterned screen, contacting the screen with a nozzle comprising a nozzle body and a conformable nozzle insert, and extruding a paste through the nozzle and screen onto the substrate. The apparatus and method are particularly useful for producing patterned lines from extruded pastes in the manufacture of microelectronic components.

Abstract: A nozzle apparatus and method of use for extruding a conductive paste through a stencil or screen onto a substrate are disclosed. The nozzle includes a body and a conformable insert for contacting the screen. The method comprises the steps of obtaining a substrate and a patterned screen, contacting the screen with a nozzle comprising a nozzle body and a conformable nozzle insert, and extruding a paste through the nozzle and screen onto the substrate. The apparatus and method are particularly useful for producing patterned lines from extruded pastes in the manufacture of microelectronic components, and are even more particularly adapted for use in producing patterns in substrates having high aspect ratio openings.

Abstract: A method of integrating an expert system having a knowledge base of elevator trouble-shooting information into the working environment of elevator service personnel, without special training of such personnel, and without compromising the security of the knowledge base. The method includes an interactive initialization procedure which includes successive, successful user and knowledge base initiated communication links between the user and knowledge base, before actual access to the knowledge base is permitted.

Abstract: A generator system to provide iridium-191m for clinical imaging applications comprises an activated carbon adsorbent loaded with a compound containing the parent nuclide, osmium-191. The generator, which has a shelf-life in excess of two weeks and does not require a scavenger column, can be eluted with physiologically compatible saline.

Abstract: Signals to be discriminated are supplied through a controllable attenuator and power splitter to first and second discriminators with response slopes which are equal and of opposite sign. The outputs of the discriminators are summed and a reference signal is subtracted from the sum to produce a control signal which adjusts the input attenuator to maintain the amplitude of the input signal constant. The outputs of the discriminators are also subtracted to provide an output signal which is a linear function of frequency and independent of input amplitude.