Abstract: A method and apparatus for determining the switching states of a target wheel used in an internal combustion engine, the method including providing a camshaft, providing a target wheel having teeth coupled to the camshaft, providing a sensor to detect the teeth of the target wheel, providing a cam phaser to phase the camshaft relative to a crankshaft of the internal combustion engine, homing the cam phaser to a known position relative to the crankshaft, rotating the crankshaft and camshaft, detecting the switching of the teeth by the sensor, referencing switching information detected by the teeth to crankshaft position information to produce a calibration for the target wheel, and storing the calibration in a controller to be use for control of the internal combustion engine.

Abstract: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.

Abstract: A camshaft system for use with an internal combustion engine including a camshaft having a plurality of lobes to actuate valves in the internal combustion engine, a sprocket coupled to the camshaft to drive the camshaft, and a target wheel coupled to the camshaft, the target wheel having an irregular surface capable of providing process data for operation of a plurality of internal combustion engine configurations.

Abstract: There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Abstract: There are provided according to the invention novel compounds of formula I 1

Abstract: Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 aliphatic, C1-6 aliphatic-amino, R7-sulfonyl, R7 sulfonyl-C1-12 aliphatic, R7-aminosulfonyl, R7-aminosulfonyl-C1-12 aliphatic, R7-sulfonylamino, R7-sulfonylamino-C1-12 aliphatic, aminosulfonylamino, di-C1-12 aliphatic amino, di-C1-12 aliphatic aminocarbonyl, di-C1-12 aliphatic aminosulfonyl, di-C1-12 aliphatic amino, di-C1-12 aliphatic aminocarbonyl, di-C1-12 aliphatic aminosulfonyl-C1-12 aliphatic, (R8)1-3-Arylamino, (R8)1-3-Arylsulfonyl, (R8)1-3-Aryl-aminosulfonyl, (R8)1-3-Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, R5 is hydrogen; and further wherein R4 and R5 are optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by ca

Abstract: The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful in inhibiting tumor growth via inhibition of such kinases as well as protecting a patient undergoing chemotherapy from chemotherapy induced alopecia.

Abstract: An improved fuel compensation method for a variable cam phase engine which predicts the phase of the cam at the midpoint of valve overlap and uses the predicted cam phase to compensate a base fuel pulse for the corresponding amount of diluent. If the cam phase is in transition to a desired value, the cam phase for purposes of compensation may be predicted based on the desired cam phase, current cam phase and its rate of change; otherwise, the cam phase is predicted based on the current cam phase. In a first interval of cam phase transition characterized by nonlinear change in cam phase, the cam phase is predicted by applying a nonlinear offset to the measured cam phase. In a second interval of cam phase transition characterized by substantially linear variation of cam phase, the cam phase is predicted by linear extrapolation of the measured cam phase, and limited to range bounded by the measured cam phase and the desired cam phase.

Abstract: An apparatus for performing a task in a confined space having an access port. The apparatus comprise: a confinement box securable to the access port of the confined space; a shell extending from the confinement box; a teleoperated arm movable between a retracted position, in which the teleoperated arm is disposed within the shell, and a deployed position, in which the teleoperated arm extends through the access port and into the confined space to perform the task; and a control system for commanding the teleoperated arm.

Abstract: A prefabricated, custom-built shower pan with a drain hole for use in a shower stall is provided. The shower pan comprises: (a) an acrylic-based solid surface upper layer; (b) a polystyrene foam layer; and (c) a planar base layer with raised edges, the base layer being durable, rigid and relatively lightweight. The polystyrene foam layer is framed by the base layer and covered by the acrylic-based solid surface upper layer. Also provided is a shower pan comprising: (a) an acrylic-based solid surface upper layer; (b) a base layer comprising a planar base with raised edges, and a system of stringers; and (c) a waterdam. The stringers are substantially straight, horizontal wooden supports which collectively incline toward the drain hole. They are relatively evenly distributed within and adhered to the rectangular-shaped base. Each stringer has an incline on its upper surface, and one end abutting one edge of the base.

Abstract: The present invention relates to a method of amplifying in vitro stemcells. In this method hematopoietic CD34.sup.+ stem and progenitor cells are isolated from human bone marrow and contacted with endothelial cells. The contacted stem cells and endothelial cells are cultured in the presence of at least one cytokine in an amount sufficient to support amplification/expansion of the hematopoietic CD34.sup.+ stem and progenitor cells. This method produces increased yields of hematopoietic CD34.sup.+ stem and progenitor cells which can be used in human therapeutics.

Abstract: A deflection electrode for use in a continuous ink jet printing device molded of powdered ultra high molecular weight polyethylene combined with carbon black and subjected to oxygen plasma treatment.

Abstract: At least one decomposable molybdenum compound selected from the group consisting of molybdenum dithiophosphates and molybdenum dithiocarbamates is mixed with a hydrocarbon-containing feed stream. The hydrocarbon-containing feed stream containing such decomposable molybdenum compound is then contacted in a hydrovisbreaking process with hydrogen under suitable hydrovisbreaking conditions.

Abstract: A method for the recovery and recycling of sodium hydroxide from the waste solution of aluminum etching operations. The method utilizes a dialysis membrane column or stack to initially remove sodium hydroxide from the waste solution and return it to the etch tank base solution sufficiently concentrated to carry on the basic etching operation. The method permits the recovery of salable quantities of aluminum hydroxide.

Abstract: A print head assembly includes the feature of snap-in, tool-less replaceability. The print head is intended for an application where extended use is expected and replacement, due to wear, will be necessary by nontechnical users of the printing system. In one embodiment, the print head utilizes two pins which slide into slots formed in the printer body. The print head is free to pivot about the two pins and is urged against a platen by the force of bias springs and a loaded pin. The loaded pin engages with, and forces upwrd on the heat-radiating fins extending from the bottom of the print head. Shelves formed in the printer body cover engage the two pins of the print head and force the print head, against the forces of the bias springs, into a proper alignment position when the cover is closed. This allows firm engagement of the print head with the platen, and proper alignment thereof, without fixing the print head to a mounting structure.

Abstract: A method and apparatus for generating acid and base regenerant solutions by utilization of a bipolar membrane electrodialysis stack. A mineral-containing salt solution is continuously circulated through the stack to produce a partially demineralized salt solution, an acid solution and a base solution. The acid solution and base solution are continuously circulated through the stack to increase the concentration thereof. The circulating salt solution is controlled to maintain the salt concentration in the range of 2% to 25% and the pH in the range of 8-11. The concentrations of the circulating acid solution and base solution are controlled to maintain the concentrations thereof in the range of 0.2N to 3.0N. The concentrated acid solution and base solution are utilized to regenerate exhausted ion-exchange resins.

Abstract: A composition of matter is prepared by a process comprising the steps of impregnating a alumina-containing support material with a thiosulfate (preferably ammonium thiosulfate), drying the thus impregnated material, impregnating the dried material with a transition metal compound, drying and calcining the transition metal impregnated material. This composition of matter is used as catalyst composition for hydrogenating unsaturated hydrocarbon compounds, and as catalyst composition for hydrotreating hydrocarbon-containing feed streams (in particular heavy oils) which contain metal and sulfur compounds as impurities.

Abstract: A composition of matter is prepared by a process comprising the steps of impregnating a alumina-containing support material with a thiosulfate (preferably ammonium thiosulfate), drying the thus impregnated material, impregnating the dried material with a transition metal compound, drying and calcining the transition metal impregnated material. This composition of matter is used as catalyst composition for hydrogenating unsaturated hydrocarbon compounds, and as catalyst composition for hydrotreating hydrocarbon-containing feed streams (in particular heavy oils) which contain metal and sulfur compounds as impurities.

Abstract: A composition of matter is prepared by a process comprising the steps of impregnating a alumina-containing support material with a thiocyanate compound (preferably ammonium thiocyanate), drying the thus impregnated material, impregnating the dried material with a transition metal compound, drying and calcining the transition metal impregnated material. This composition of matter is used as catalyst composition for hydrotreating of hydrocarbon-containing feed streams (in particular heavy oils) which contain metal and sulfur compounds as impurities.In another embodiment, a hydrotreating process comprises contacting hydrocarbon-containing feed stream (in particular heavy oils), which contains compounds of sulfur and metals, in the presence of a fixed catalyst bed comprising at least one layer (X) of impregnated substantially spherical alumina-containing particles which have been prepared by a process comprising the steps of impregnating a specific starting material with NH.sub.

Abstract: A composition of matter is prepared by a process comprising the steps of impregnating a alumina-containing support material with a thiocyanate (preferably ammonium thiocyanate), drying the thus impregnated material, impregnating the dried material with a transition metal compound, drying and calcining the transition metal impregnated material. This composition of matter is used as catalyst composition for hydrotreating of hydrocarbon-containing feed streams (in particular heavy oils) which contain metal and sulfur compounds as impurities.In another embodiment, a hydrotreating process comprises contacting hydrocarbon-containing feed stream (in particular heavy oils), which contains compounds of sulfur and metals, in the presence of a fixed catalyst bed comprising (X) at least one layer of impregnated substantially spherical alumina-containing particles which have been prepared by a process comprising the steps of impregnating specific starting material with NH.sub.