Abstract: The present invention provides oxadiazoanthracene derivatives of the formula (I), wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, pharmaceutical compositions comprising oxadiazoanthracene derivatives, use of the oxadiazoanthracene derivatives for the preparation of pharmaceutical compositions, methods of use thereof for the treatment and/or prevention of disorders and diseases, such as diabetes, and intermediates useful for the preparation of oxadiazoanthracene derivatives of Formula (I).

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Abstract: In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5?-UTR-dependent translation of VEGF and methods for identifying such compounds are provided.

Abstract: The present invention enables a content provider to dynamically assemble content at the edge of the Internet, preferably on content delivery network (CDN) edge servers. Preferably, the content provider leverages an “edge side include” (ESI) markup language that is used to define Web page fragments for dynamic assembly at the edge. Dynamic assembly improves site performance by catching the objects that comprise dynamically generated pages at the edge of the Internet, close to the end user. The content provider designs and develops the business logic to form and assemble the pages, for example, by using the ESI language within its development environment. Instead of being assembled by an application/web server in a centralized data center, the application/web server sends a page template and content fragments to a CDN edge server where the page is assembled. Each content fragment can have its own cacheability profile to manage the “freshness” of the content.

Abstract: A method of protecting an intake manifold of an engine of a hybrid propulsion system including an electric motor comprises detecting a reverse rotation of an engine. A fuel injector of the engine that is rotating in reverse is commanded to cease operation. A spark plug of the engine that is rotating in reverse is commanded to cease operation. The ceasing of reverse rotation of the engine is then confirmed.

Abstract: A process and system for purifying water is disclosed. For example, in one embodiment, the process may be used to remove a divalent salt, such as calcium sulfate, from a water source in order to prevent the divalent salt from precipitating during the process. The water source, for instance, may be fed to an ion separating device, such as an electrodialysis device. In the electrodialysis device, an ion exchange takes place between the divalent salt and another salt, such as a monovalent salt to produce two concentrated salt streams that contain salts having greater solubility in water than the divalent salt. In one embodiment, the two salt streams that are produced may then be combined to precipitate the divalent salt in a controlled manner. During the process, various other components contained within the water feed stream may also be removed from the stream and converted into useful products. In one particular embodiment, the process is configured to receive a byproduct stream from a reverse osmosis process.

Abstract: A Bernoulli Effect pick-up device (1) for the handling of products (20) comprises a surface (4) adapted such that gaseous fluid flow across said surface (4) provides a pick-up force to be generated, by the Bernoulli Effect, in a direction towards said surface (4), and a conduit (2) for the supply of the gaseous fluid. The conduit (2) has an outlet opening (5) at the surface (4) and is adapted to supply gaseous fluid in a direction opposed to the pick-up direction. The outlet (5) of the conduit (2) is associated with a deflector (9) for directing gaseous fluid across the surface (4) and preventing direct impingement of the fluid on a product (2) that has been picked-up by the device (1). The product (20) may for example be a slice of a foodstuff, e.g. tomato or hard-boiled egg.

Abstract: An apparatus to facilitate field assessment of static structure sites to provide data in a predetermined format acceptable to a taxing authority, including a personal computing device having a graphic display screen, a user interface, and application software. The user interface is arranged to accept alphanumeric data provided by a user of the apparatus and also accept graphic input from the user representative of structural features of the static structure. The application software is arranged to provide a real-time display on the graphic display screen of dimensional data associated with the graphic inputs as they are entered by the user. The application software is also arranged to compute dimensional attributes of enclosed polygons resulting from the graphic input by the user.

Abstract: One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a polymer-derivatized xenoantigen (hereinafter “xenopolymer”) effective for inhibiting or lessening the severity of hyperacute rejection response (HAR), or other immunological response to the graft, that is dependent on the presence of the xenoantigen on the grafted tissues or cells. In certain embodiments, the xenopolymer is administered in an amount sufficient to neutralize host antibodies (“xenoreactive antibodies” or “XNA”) immunoreactive with the xenoantigen. The xenopolymer may additionally, or alternatively, be used as a tolerogen (or anergen) for the xenoantigen, e.g., able to suppress, to some degree, the production/secretion of XNAs by the immune system of the host.

Abstract: The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamcinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride.

Abstract: In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5?-UTR-dependent translation of VEGF and methods for identifying such compounds are provided.

Abstract: A method for applying a liner to a pipe is disclosed. The methodology includes inserting an apparatus within the pipe and moving the apparatus at a predetermined speed through the pipe. The method sprays a material from a spray head secured to the apparatus. The methodology also includes an oscillation system wherein the spray head assembly will move relative to the base assembly thus creating an over lapping pattern for the spray coating being applied to the interior surface of the pipeline. This oscillation system will allow for a more uniform coating to be applied.

Abstract: A method for easing stress on a patient in a stressful treatment area, including the steps of: (a) providing at least one page of a periodically issued ceiling newsletter; (b) mounting at least two members of an attachment mechanism on a ceiling of the treatment area; (c) mounting at least two corresponding members of the attachment mechanism on a back side of each ceiling newsletter page; and (d) removably mounting the ceiling newsletter on the treatment area ceiling. Also included herein is a method including the steps of: a) subscribing to a ceiling newsletter; b) transcribing subscriber information to a customer list; c) mailing the ceiling newsletter issues to the subscribers periodically; and d) receiving the issue, affixing corresponding attachment mechanism members to the ceiling and to the back of each page of the ceiling newsletter, and removably attaching the ceiling newsletter to the treatment area ceiling.

Abstract: A method of making a multilayered circuitized substrate in which a continuous process is used to form electrically conductive layers which each will form part of a sub-composite. The sub-composites are then aligned such that openings within the conductive layers are also aligned, the sub-composites are then bonded together, and a plurality of holes are then laser drilled through the entire thickness of the bonded structure.

Abstract: This invention relations to a polymerizable composition for forming a photochromic article of glass transition temperature of at least 50 ° C. on curing, the composition comprising: (a) a polymerizable composition comprising a monomer component or resin formed therefrom; and (b) a photochromic dye monomer comprising a photochromic moiety and at least one oligomeric group having at least one group reactive with the monomer component during or following curing wherein the oligomer group comprises a multiplicity of monomer units selected from siloxane, alkylene and substituted alkylene.

Abstract: A system for filtering a signal includes a plurality of filter modules coupled in series. Each filter module includes a filter and a variable gain element. Each filter is capable of. receiving an input signal, attenuating a portion of the input signal that is outside a passband associated with the filter, and outputting at least a portion of the input signal that is within the passband associated with the filter. Each variable gain element is capable of receiving a control signal and inducing a gain in an output of the filter based on the control signal.

Abstract: A method for generating phase signals includes triggering a phase register to output a binary number stored in the phase register, wherein the phase register is triggered based at least in part on a voltage signal provided by a voltage controlled oscillator. The method also includes providing an input signal to a decoder, wherein the input signal is based at least in part on the binary number output by the phase register and the decoder is operable to generate phase signals in response to the input signals. The method further includes incrementing the binary number stored in the phase register and repeating the triggering and providing steps after the binary number is incremented.

Abstract: A combination memorial and storage urn for cremated remains is disclosed, and may include a separate container/support and a pedestal for displaying the memorial.

Abstract: A reverse rotation detection system for an engine with at least one camshaft and a crankshaft includes a camshaft position sensor that generates a camshaft position signal based on a rotation of the camshaft. A second sensor input device generates a crankshaft position signal based on a rotation of the crankshaft. A control module detects a reverse rotation condition of the engine from the camshaft position signal and the crankshaft position signal, wherein the control module compares the camshaft position signal to the crankshaft position signal to determine an engine position. Based on the engine position the control module compares the camshaft position signal to an expected signal to determine a reverse rotation condition.

Abstract: A system for receiving radio-frequency signals includes a first input path, a second input path, a selector, and a mixer. The first input path is capable of transmitting to the mixer a first input signal propagating in a first portion of the radio-frequency spectrum, while the second input path is capable of transmitting to the mixer a second input signal propagating in a second portion of the radio-frequency spectrum. The selector is capable of selectively coupling one of the first input path and the second input path to the mixer. Additionally, the mixer is capable of receiving an input signal and downconverting at least a portion of the input signal that is propagating within a selected frequency range. The mixer is also capable of outputting the downconverted portion of the input signal.