Abstract: The present invention relates to a construction machine, said construction machine comprising a brake assembly for braking the machine, as well as an operator platform. The operator platform comprises at least one operator seat with a total of at least two operating positions for a machine operator at opposite ends of the operator platform, and an actuation device for foot actuation of the brake assembly. According to essential aspects of the present invention, the actuation device for the brake assembly comprises a brake beam which extends transversely to the working direction of the construction machine and which can be operated by foot from said two operating positions, and the actuation device further comprises an actuator for the brake beam, which is arranged below the brake beam.

Abstract: The present invention relates to methods for treating and/or preventing SIRS and/or sepsis comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of SIRS and/or sepsis.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: The present invention relates to a rubber tire roller for ground compaction, comprising a machine frame and an operating platform and front and rear undercarriages supporting the machine frame, wherein the undercarriages each comprise at least one wheel. A fundamental idea of the present invention lies in viewing indentations that are open to the side.

Abstract: A closure latch assembly for a decklid configured to provide a power release operation and a power cinch operation. The power cinch operation is a dual-stage cinch operation having a first non-driven cinching stage and a second driven cinching stage. The first cinching stage utilizes the weight of the decklid to drive the decklid from a pop-up position to a cinched position. The second cinching stage utilizes a cinch mechanism to drive the decklid from its cinched position into a fully-closed position.

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: A support is provided, comprising a first bar with a first abutment element, a second bar with a second abutment element, and a guiding device by which the first bar is displaceably guided on the second bar. An actuating device which acts on the first bar and which comprises an actuating element is arranged on the second bar. A displacement of the first bar in a first direction of displacement can be initiated by actuation of the actuating element. The first direction of displacement is a direction of increase in distance between the first abutment element and the second abutment element. The actuating device comprises a blocking device which blocks a displacement of the first bar in relation to the second bar in a second direction of displacement, which is opposite the first direction of displacement, at least when no active releasing action occurs at the blocking device.

Abstract: The present invention provides a novel process for producing rubber-modified bitumen using vulcanized rubber.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: The present invention relates to a road paver for paving paving material in a paving direction (a), comprising a machine frame, a driver's platform, a drive motor, a chassis with at least a left travel unit and a right travel unit, a material container arranged at the front of the road paver in the paving direction (a) for receiving paving material, the material container comprising a left container half and a right container half, which each have a container floor, a rising container sidewall and a rising container rear wall, and a longitudinal conveying device configured to transport paving material from the material container to a paving screed arranged at the rear of the road paver in the paving direction, wherein the container halves can be moved out of a filling position in order to move the paving material onto the longitudinal conveying device, wherein at least one container half has a viewing indentation, which extends from the container rear wall to the container floor in such a way that the ground

Abstract: The invention relates to the treatment or prevention of renal impairment and/or complications using a SGLT-2 inhibitor, for example in patients diagnosed with metabolic disorders and related conditions.

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia.

Abstract: The invention relates to a compact paver comprising a machine frame, a drive motor, travel units, a receiving container at the front in relation to the paving direction for receiving paving material, a longitudinal conveying device with which the paving material can be conveyed from the receiving container in a rearward direction in relation to the paving direction, a transverse distribution device with which the paving material can be distributed on the ground surface transversally to the paving direction, a paving screed that is height-adjustable in relation to the machine frame for compacting and smoothing the paving material distributed on the ground surface behind the transverse distribution device in the paving direction, and an operating platform mounted on the machine frame and arranged behind the receiving container in the paving direction.

Abstract: The invention relates to a height-adjustable operating platform of a compact paver comprising a machine frame, a drive motor, travel units, a receiving container at the front in relation to the paving direction for receiving paving material, a longitudinal conveying device with which the paving material can be conveyed from the receiving container in a rearward direction in relation to the paving direction, a transverse distribution device that is height-adjustable in relation to the machine frame and with which the paving material can be distributed on the ground surface transversally to the paving direction, a paving screed that is height-adjustable in relation to the machine frame for compacting and smoothing the paving material distributed on the ground surface behind the transverse distribution device in the paving direction, an operating platform mounted on the machine frame and arranged behind the receiving container in the paving direction and a method for operating a compact paver.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.