Abstract: The present invention relates to an operator platform for a construction machine and to a construction machine, particularly a road construction machine such as a road milling machine or a road paver, with an operator platform. The operator platform comprises an operator platform base, an operating panel and an operator seat, wherein an operating panel mount with a pivoting device is provided, by means of which the operating panel is pivotable about a vertical pivot axis between a first pivoting position and a second pivoting position. The operating panel mount comprises a height adjustment device which is configured such that the operating panel can be locked at different height positions independently of the pivoting positions.

Abstract: Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: A fluid cartridge (100) for dispensing a fluid, the fluid cartridge (100) comprising a casing (102) for accommodating the fluid, a pressure feed interface (104) configured for being coupled to a pressure feed unit (106) for feeding the fluid in the casing (102) with pressurized medium, a fluid dispensing unit (108) configured for generating particles, particularly fluid particles, upon feeding the fluid in the casing (102) with pressurized medium, and a fluidic path (110) in the casing (102) being opened or openable for enabling the particles, particularly fluid particles, to leave the casing (102) through the fluidic path (110).

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.

Abstract: A Fabry-Pérot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.

Abstract: A storage medium on which geographic data of a geographic region are stored together as map units, a corresponding method for generating a map from the geographic data, and a corresponding navigation device. In order to reduce the amount of data to be processed, the map units are structured hierarchically, map units of an nth order respectively corresponding to one geographic partial region, n being a natural number, and map units of an (n+1)th order respectively corresponding to one geographic subregion of one of the partial regions.

Abstract: A device (1) for discharging an electrical overvoltage includes an overvoltage discharge unit (10) having a non-linear current/voltage characteristic at least in sections. A first terminal electrode (16) of the overvoltage discharge unit (10) is connected to a high-voltage terminal (18) of the device (1). A second terminal electrode (22) of the overvoltage discharge unit (10) is connected to a low-voltage or ground terminal (24) of the device (1). The overvoltage discharge unit (10) is surrounded, at least in sections, by an insulating body (20). A cutting element (40) is connected to the low-voltage or ground terminal (24) and is disposed close to a high-voltage section of the overvoltage discharge unit (10). The cutting element cuts into the insulating body (20) when the insulating body (20) distends as a result of an electrical overload, enabling an are to be sparked and stabilized between the high-voltage section and the cutting element (40).

Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The invention relates to the treatment of metabolic disorders in an overweight or obese patient characterized in that empagliflozin and one or more antiobesity drugs are administered to the patient.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.

Abstract: A method for detecting an imperfect mounting of an essentially rod-shaped metallic object in a metallic hollow shaft is provided. The imperfect mounting may lead to the formation of metallic particles. The rod-shaped object is mounted electrically insulated from the hollow shaft. The electrical resistance between the rod-shaped object and the hollow shaft is measured. An alert is issued when the electrical resistance is lower than a predefined level. A device includes a spin unit with a hollow drive shaft and a nozzle mounted inside the hollow shaft. The device is configured to use the inventive method.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.

Abstract: The present invention relates to the use of a certain DPP-4 inhibitor for use in a patient being at risk of or having heart failure with preserved ejection fraction (HFpEF).

Abstract: The present invention relates to an articulated pendulum joint for an articulated vehicle, especially a construction machine. It comprises a front connection element for connecting a front frame part of the articulated vehicle, a rear connection element for connecting a rear frame part of the articulated vehicle, and an articulation joint, via which the front connection element and the rear connection element are mutually connected in a pivotable manner relative to each other about a steering axis (AS). A pendulum joint is further provided, via which the front connection element and the rear connection element are mutually connected in a twistable manner relative to each other about a pendulum axis (AT), wherein the steering axis (AS) of the articulation joint is inclined about an acute angle ? relative to the pendulum axis (AT).

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: A swept source OCT system and related method are disclosed. The system comprises a control device for operating a tunable light source in response to an electronic sweep control signal such that the tunable light source carries out wave length sweeps with a repetition rate fsweep, which depends on the frequency of the sweep control signal. The system further comprises a detection device for the time-resolved detection of an interference signal from a sample beam and a reference beam with the help of a detection cycle signal. The sweep control signal and the detection cycle signal are phase-locked, or means for creating a signal or signal sequence are provided, said signal or signal sequence being characterising for the frequency relationship and/or the relative phase position of the sweep control signal and detection cycle signal.