Abstract: A computer-implemented method executed by one or more computer servers includes receiving a notification from a communication device, determining whether one or more other communication devices are within a stationary geofence, and in response to the notification, sending an emergency alert to the other communication devices determined to be within the stationary geofence. The computer-implemented method may further include receiving an acknowledgement of the emergency alert from at least one of the other communication devices determined to be within the stationary geofence and/or sending data indicating an approximate location of the communication device and an associated tolerance of the approximate location. Other example computer-implemented methods, communication devices including software applications, and systems are also disclosed.

Abstract: When cold and in the non-coated state, the aerodynamic profile is substantially identical to a nominal profile determined by the Cartesian coordinates X,Y, Zadim given in Table 1, in which the coordinate Zadim is the quotient D/H where D is the distance of the point under consideration from a first reference plane P0 situated at the base of the nominal profile, and H is the height of said profile measured from the first reference plane to a second reference plane P1. The measurements D and H are taken radially relative to the axis of the turbine, while the X coordinate is measured in the axial direction of the turbine.

Abstract: When cold and in the non-coated state, the aerodynamic profile is substantially identical to a nominal profile determined by the Cartesian coordinates X,Y, Zadim given in Table 1, in which the coordinate Zadim is the quotient D/H where D is the distance of the point under consideration from a first reference plane P0 situated at the base of the nominal profile, and H is the height of said profile measured from the first reference plane to a second reference plane P1. The measurements D and H are taken radially relative to the axis of the turbine, while the X coordinate is measured in the axial direction of the turbine.

Abstract: When cold and in the non-coated state, the aerodynamic profile is substantially identical to a nominal profile determined by the Cartesian coordinates X,Y, Zadim given in Table 1, in which the coordinate Zadim is the quotient D/H where D is the distance of the point under consideration from a first reference plane P0 situated at the base of the nominal profile, and H is the height of said profile measured from the first reference plane to a second reference plane P1. The measurements D and H are taken radially relative to the axis of the turbine, while the X coordinate is measured in the axial direction of the turbine.

Abstract: A computer-implemented method executed by one or more computer servers includes receiving a notification from a first communication device. The notification indicates an armed intruder within a first stationary geofence. The method further includes determining whether one or more of a first plurality of communication devices are within a second stationary geofence different than the first stationary geofence, and in response to the notification, providing an emergency alert to the communication device(s) determined to be within the second stationary geofence. Other example computer-implemented methods, communication devices including software applications, and systems for notifying one or more LEOs of an armed intruder by a premises personnel associated with a premises are also disclosed.

Abstract: The invention features methods, devices, pharmaceutical compositions, and kits for treating or preventing acute vascular leak. Such methods may involve contacting an effective amount of bosutinib for treating or preventing acute vascular leak with a subject in need thereof. Conditions associated with acute vascular leak include ischemic brain injury, stroke, septic shock, anthrax lethal toxin, anaphylaxis, trauma, severe episodic vasculitis, acute lung injury, ventilator-induced lung injury, transfusion-related acute lung injury, acute respiratory distress syndrome, severe burn injury, circulatory shock, capillary leak syndrome, and ischemia-reperfusion injury. The invention also features automatic injection devices, resuscitation fluids, or pharmaceutical compositions comprising an effective amount of bosutinib for treating or preventing acute vascular leak. The invention further features kits for use in the methods of the invention.

Abstract: A pneumatic vehicle tire includes a carcass extending between two bead cores. A belt structure is provided between the carcass and a tread strip which is connected with a pair of sidewalls. A runflat reinforcement is arranged at the inner side of each sidewall. A reinforcer is arranged within each bead portion of the tire. A bead filler extends from the bead ring along the reinforcer. To improve the runflat performance, handling and comfort properties of such a runflat tire, the reinforcer is arranged at the inner side of the bead filler. The reinforcer includes metal cords. The bead filler which extends beyond an end of the reinforcer, is made of a soft rubber compound with an IHRD harness lower than 80.

Abstract: A computer-implemented method executed by one or more computer servers includes receiving a notification from a communication device, determining whether one or more other communication devices are within a stationary geofence, and in response to the notification, sending an emergency alert to the other communication devices determined to be within the stationary geofence. The computer-implemented method may further include receiving an acknowledgement of the emergency alert from at least one of the other communication devices determined to be within the stationary geofence and/or sending data indicating an approximate location of the communication device and an associated tolerance of the approximate location. Other example computer-implemented methods, communication devices including software applications, and systems are also disclosed.

Abstract: A microscope probe includes a substrate; an optical resonator disposed on the substrate and including an optical resonance property; a displacement member disposed on the substrate and separated from the optical resonator, the displacement member including: a first end disposed distal to the optical resonator; and a second end disposed proximate to the optical resonator; and a coupling member disposed on the substrate and connecting the displacement member to the substrate, wherein the first end is configured to probe a sample and to be displaced in response to a condition of the sample, the displacement member is configured to communicate displacement of the first end to the second end, and the second end is configured to change the optical resonance property in response to displacement of the second end.

Abstract: A computer-implemented method executed by one or more computer servers includes receiving a notification from a first communication device. The notification indicates an armed intruder within a first stationary geofence. The method further includes determining whether one or more of a first plurality of communication devices are within a second stationary geofence different than the first stationary geofence, and in response to the notification, providing an emergency alert to the communication device(s) determined to be within the second stationary geofence. Other example computer-implemented methods, communication devices including software applications, and systems for notifying one or more LEOs of an armed intruder by a premises personnel associated with a premises are also disclosed.

Abstract: A microscope probe includes a substrate; an optical resonator disposed on the substrate and including an optical resonance property; a displacement member disposed on the substrate and separated from the optical resonator, the displacement member including: a first end disposed distal to the optical resonator; and a second end disposed proximate to the optical resonator; and a coupling member disposed on the substrate and connecting the displacement member to the substrate, wherein the first end is configured to probe a sample and to be displaced in response to a condition of the sample, the displacement member is configured to communicate displacement of the first end to the second end, and the second end is configured to change the optical resonance property in response to displacement of the second end

Abstract: A lancing device for ejecting a lancet having a pricking element protruding therefrom along an ejection axis is provided. The lancing device includes a front cap having an opening facing against an object to be pricked, a lancet holder slideable between a cocked position and a pricking position, and a safety switch moveable between a safety position and a passing position, wherein the pricking element extends beyond the opening when the lancet is ejected; the safety switch prevents the lancet holder form being cocked when the safety switch is in the safety position, and the safety switch allows the lancet holder to be cocked and moved when the safety switch is in the passing position.

Abstract: The present invention relates to a method for the reliable and reproducible preparation of 4-[17?-methoxy-17?-methoxymethyl-3-oxoestra-4,9-dien-11?-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).

Abstract: A pneumatic vehicle tire includes a carcass extending between two bead cores. A belt structure is provided between the carcass and a tread strip which is connected with a pair of sidewalls. A runflat reinforcement is arranged at the inner side of each sidewall. A reinforcer is arranged within each bead portion of the tire. A bead filler extends from the bead ring along the reinforcer. To improve the runflat performance, handling and comfort properties of such a runflat tire, the reinforcer is arranged at the inner side of the bead filler. The reinforcer includes metal cords. The bead filler which extends beyond an end of the reinforcer, is made of a soft rubber compound with an IHRD hardness lower than 80.

Abstract: The present invention relates to a method for the reliable and reproducible preparation of 4-[17?-methoxy-17?-methoxymethyl-3-oxoestra-4,9-dien-11?-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).

Abstract: The present invention relates to the use of 2-alkoxyestrogen sulfamates of general formula I wherein R1 and R2 independently represent H, methyl, C1-C4 acyl, benzoyl R3 represents C1-C4 alkyl or a group of formula CnFmHo, wherein n=1, 2, 3, 4, 5 or 6, m>1, and m+o=2n+1, R4 and R5 in each case represent H or, together, a methylene group or an additional double bond, R6 represents H, R7 represents OH, OC1-C4-alkyl, OC1-C11-acyl or OSO2NR1R2, the dashed lines in the B and C rings of the steroid skeleton additionally representing up to two double bonds, for the production of a medical drug for the treatment of tumor diseases which can be affected positively by inhibiting the tubulin polymerization. The inventive compounds are distinguished by the 2-alkoxy substitution in conjunction with the 17-hydroxy substitution. They have a special effect with regard to inhibiting tubulin polymerization and can be used, for example, for the treatment of prostate cancers.

Abstract: The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention.

Abstract: A lancing device for ejecting a lancet having a pricking element protruding therefrom along an ejection axis is provided. The lancing device includes a front cap having an opening facing against an object to be pricked, a lancet holder slideable between a cocked position and a pricking position, and a safety switch moveable between a safety position and a passing position, wherein the pricking element extends beyond the opening when the lancet is ejected; the safety switch prevents the lancet holder form being cocked when the safety switch is in the safety position, and the safety switch allows the lancet holder to be cocked and moved when the safety switch is in the passing position.

Abstract: The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in the preparation of the solutions of the present invention. The present invention also provides a device for perfusing tissues and organs with the solutions of the present invention.

Abstract: The present invention relates to a method for the reliable and reproducible preparation of 4-[17?-methoxy-17?-methoxymethyl-3-oxoestra-4,9-dien-11?-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).