Patents by Inventor Thomas A. Szyperski

Thomas A. Szyperski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using reduced dimensionality nuclear magnetic resonance spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins
    Publication number: 20020041850
    Abstract: The present invention discloses eight new reduced dimensionality (RD) triple resonance nuclear magnetic resonance (NMR) experiments for measuring chemical shift values of certain nuclei in a protein molecule. The RD 3D HA,CA,(CO),N,HN NMR experiment and the RD 3D H,C,(C-TOCSY-CO),N,HN NMR experiment are designed to yield “sequential” connectivities, while the RD 3D H&agr;&bgr;,C&agr;&bgr;,CO,HA NMR experiment and the RD 3D H&agr;&bgr;,C&agr;&bgr;,N,HN NMR experiment provide “intraresidue” connectivities. The RD 3D H,C,C,H-COSY NMR experiment, the RD 3D H,C,C,H-TOCSY NMR experiment, and the RD 2D H,C,H-COSY NMR experiment allow one to obtain assignments for aliphatic and aromatic side chain chemical shifts, while the RD 2D HB,CB,(CG,CD),HD NMR experiment provide information for the aromatic side chain chemical shifts.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 11, 2002
    Inventor: Thomas A. Szyperski