Patents by Inventor Thomas A. Tombrello

Thomas A. Tombrello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150336502
    Abstract: At least one embodiment of this disclosure includes a method for an autonomous vehicle (e.g., a fully autonomous or semi-autonomous vehicle) to communicate with external observers. The method includes: receiving a task at the autonomous vehicle; collecting data that characterizes a surrounding environment of the autonomous vehicle from a sensor coupled to the autonomous vehicle; determining an intended course of action for the autonomous vehicle to undertake based on the task and the collected data; and conveying a human understandable output via an output device, the human understandable output expressly or implicitly indicating the intended course of action to an external observer.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 26, 2015
    Inventors: W. Daniel HILLIS, Kjerstin I. WILLIAMS, Thomas A. TOMBRELLO, James W. SARRETT, Luke W. KHANLIAN, Adrian L. KAEHLER, Russel HOWE
  • Publication number: 20150299757
    Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 22, 2015
    Inventors: Aditya RAJAGOPAL, Axel SCHERER, Michael D. HENRY, Sameer WALAVALKAR, Thomas A. TOMBRELLO, Andrew P. HOMYK
  • Publication number: 20150283513
    Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Inventors: SAMEER WALAVALKAR, ADITYA RAJAGOPAL, AXEL SCHERER, THOMAS A. TOMBRELLO
  • Patent number: 9099436
    Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: August 4, 2015
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya Rajagopal, Axel Scherer, Michael D. Henry, Sameer Walavalkar, Thomas A. Tombrello, Andrew P. Homyk
  • Patent number: 9089819
    Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: July 28, 2015
    Assignee: California Institute of Technology
    Inventors: Sameer Walavalkar, Aditya Rajagopal, Axel Scherer, Thomas A. Tombrello
  • Patent number: 9005548
    Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 14, 2015
    Assignee: California Institute of Technology
    Inventors: Michael D. Henry, Andrew P. Homyk, Axel Scherer, Thomas A. Tombrello, Sameer Walavalkar
  • Publication number: 20150050746
    Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
    Type: Application
    Filed: October 29, 2014
    Publication date: February 19, 2015
    Inventors: Michael D. HENRY, Andrew P. HOMYK, Axel SCHERER, Thomas A. TOMBRELLO, Sameer WALAVALKAR
  • Publication number: 20140357974
    Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.
    Type: Application
    Filed: August 19, 2014
    Publication date: December 4, 2014
    Inventors: Aditya RAJAGOPAL, Axel SCHERER, Michael D. HENRY, Sameer WALAVALKAR, Thomas A. TOMBRELLO, Andrew P. HOMYK
  • Patent number: 8841712
    Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: September 23, 2014
    Assignee: California Institute of Technology
    Inventors: Aditya Rajagopal, Axel Scherer, Michael D. Henry, Sameer Walavalkar, Thomas A. Tombrello, Andrew P. Homyk
  • Publication number: 20140234848
    Abstract: Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing. Unique organisms can also be used for identification. The nucleic acids can be encapsulated in organic materials such as saccharide-based desiccants.
    Type: Application
    Filed: December 23, 2013
    Publication date: August 21, 2014
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya RAJAGOPAL, Thomas A. TOMBRELLO
  • Publication number: 20140213471
    Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.
    Type: Application
    Filed: January 23, 2014
    Publication date: July 31, 2014
    Applicant: California Institute of Technology
    Inventors: Aditya RAJAGOPAL, Mark D. GOLDBERG, Erika F. GARCIA, Xiomara L. MADERO, Thomas A. TOMBRELLO, Axel SCHERER
  • Publication number: 20130327645
    Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.
    Type: Application
    Filed: August 14, 2013
    Publication date: December 12, 2013
    Applicant: California Institute of Technology
    Inventors: Sameer Walavalkar, Axel Scherer, Thomas A. Tombrello, Aditya Rajagopal, Andrew P. Homyk, Erika Garcia
  • Patent number: 8535512
    Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: September 17, 2013
    Assignee: California Institute of Technology
    Inventors: Sameer Walavalkar, Axel Scherer, Thomas A. Tombrello, Aditya Rajagopal, Andrew P. Homyk, Erika Garcia
  • Publication number: 20120118739
    Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.
    Type: Application
    Filed: September 29, 2011
    Publication date: May 17, 2012
    Inventors: Sameer Walavalkar, Axel Scherer, Thomas A. Tombrello, Aditya Rajagopal, Andrew P. Homyk, Erika Garcia
  • Publication number: 20120080361
    Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.
    Type: Application
    Filed: September 30, 2011
    Publication date: April 5, 2012
    Inventors: Sameer Walavalkar, Aditya Rajagopal, Axel Scherer, Thomas A. Tombrello
  • Publication number: 20100309112
    Abstract: Pixel devices, comprising ink particles differing in electrical charge, mass and/or shape contained within a fluidic structure, and related arrays methods and systems.
    Type: Application
    Filed: June 8, 2010
    Publication date: December 9, 2010
    Inventors: Aditya Rajagopal, Christopher I. Walker, Saurabh Vyawahare, Axel Scherer, Thomas A. Tombrello
  • Publication number: 20100215543
    Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Inventors: Michael D. HENRY, Andrew P. Homyk, Axel Scherer, Thomas A. Tombrello, Sameer Walavalkar
  • Patent number: 4526624
    Abstract: Films (12) of a metal such as gold or other non-insulator materials are firmly bonded to other non-insulators such as semiconductor substrates (10), suitably silicon or gallium arsenide by irradiating the interface with high energy ions. The process results in improved adhesion without excessive doping and provides a low resistance contact to the semiconductor. Thick layers can be bonded by depositing or doping the interfacial surfaces with fissionable elements or alpha emitters. The process can be utilized to apply very small, low resistance electrodes (78) to light-emitting solid state laser diodes (60) to form a laser device 70.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: July 2, 1985
    Assignee: California Institute of Technology
    Inventors: Thomas A. Tombrello, Yuanxun Qiu, Marcus H. Mendenhall
  • Patent number: 4457972
    Abstract: Films (12) of gold, copper, silicon nitride, or other materials are firmly bonded to insulator substrates (12) such as silica, a ferrite, or Teflon (polytetrafluorethylene) by irradiating the interface with high energy ions. Apparently, track forming processes in the electronic stopping region cause intermixing in a thin surface layer resulting in improved adhesion without excessive doping. Thick layers can be bonded by depositing or doping the interfacial surfaces with fissionable elements or alpha emitters.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: July 3, 1984
    Assignee: California Institute of Technology
    Inventors: Joseph E. Griffith, Yuanxun Qiu, Thomas A. Tombrello
  • Patent number: 4194115
    Abstract: Apparatus and method for determining helium to hydrogen ratios in a gaseous sample by measurement of forward scattering products due to alpha particle collisions with helium and hydrogen contained within the gaseous sample. More specifically, an apparatus is disclosed in which a gaseous sample, contained within an enclosure, is bombarded by alpha particles created by a self contained radioactive source. Baffles are positioned in the enclosure so that only scattering products falling within a predetermined forward scattering angular range can impact a detector assembly. In an embodiment scattered particles are detected by two detectors mounted in tandem, the first completely blocking the second detector with respect to incident scattering products. This embodiment is based on the principle that scattering products have a forward scattering angle .theta. greater than 15 degrees due to alpha particle/hydrogen collisions comprise only recoil protons.
    Type: Grant
    Filed: November 7, 1978
    Date of Patent: March 18, 1980
    Inventors: Robert A. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Frosch, A. Bruce Whitehead, Thomas A. Tombrello