Patents by Inventor Thomas Alberts

Thomas Alberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7888106
    Abstract: The present invention provides a microarray for multiple sample analysis that does not require an alignment of well walls with corresponding probe sets. Methods for building and using such a microarray are also within the scope of the present invention.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 15, 2011
    Assignee: Roche Nimblegen, Inc.
    Inventors: Thomas Albert, Mark McCormick
  • Publication number: 20100331204
    Abstract: The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences.
    Type: Application
    Filed: January 28, 2010
    Publication date: December 30, 2010
    Inventors: Jeff Jeddeloh, Todd Richmond, Matthew Rodesch, Daniel Gerhardt, Paul Marrione, Thomas Albert
  • Publication number: 20100310198
    Abstract: Plastic bag (WB) containing stacked soft hygienic products (FCS), e.g. sanitary napkins, panty liners, diapers, or the like, which can be made on-line from a roll of film. The plastic bag comprises one MD seal (35) along one closure corner (46) and is without a fold line in the center of a side panel. An artwork may be present which is continuous in the area of the MD seal. The products may be in a compressed state in the closed plastic bag.
    Type: Application
    Filed: June 3, 2010
    Publication date: December 9, 2010
    Inventors: Markus Port, Stephan Spiekers, Ibrahim Ulas, Thomas Albert Reinhold Wessel
  • Patent number: 7846660
    Abstract: The present invention is a method for synthesizing microarrays having different oligonucleotides present within one feature area of the array. The method utilizes the techniques common to microarray synthesis, but limits the duration in which selected feature areas on the array are initially dosed with light so as to only deprotect a calculated ratio of the compounds forming the array's binding layer. The compounds initially deprotected are capped with a non-photosensitive protecting group, such as di-methoxy-trityl, to inhibit their involvement in the synthesis of a first group of DNA strands built onto the array. Once the first group of DNA strands have been synthesized, the original deprotected group may then be further processed to build one or more groups of DNA strands in the same feature area as the first group of DNA strands. The present invention also includes microarrays manufactured using the method.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: December 7, 2010
    Assignee: Roche Nimblegen, Inc.
    Inventors: Thomas Albert, Jason Norton, Roland Green
  • Publication number: 20100275802
    Abstract: According to the invention there is provided an impact initiated pyrotechnic target including an impact initiated pyrotechnic composition which can be initiated by the impact of an inert projectile, said pyrotechnic composition including: an oxidising agent; optionally, a fuel or reducing agent; a sensitiser in the form of a sulfur containing compound; and optionally, a binder.
    Type: Application
    Filed: November 14, 2008
    Publication date: November 4, 2010
    Applicant: Simon Richard Green
    Inventors: Benjamin John Green, Paul Thomas Albert Mulvihill
  • Publication number: 20100230063
    Abstract: The invention relates to the field of papermaking. More in particular, the invention relates to a method of reducing the phenomenon of vessel picking in papermaking. In accordance with the invention it has surprisingly been found that the problem vessel picking may be significantly reduced by using a cationic amylopectin starch in the paper pulp, i.e. in the wet-end.
    Type: Application
    Filed: June 8, 2007
    Publication date: September 16, 2010
    Inventors: Thomas Albert Wielema, Jan Baas
  • Patent number: 7753056
    Abstract: A smokable rod for a smoking article, such as a cigarette, possesses a co-axial or concentric construction. The outer material that circumscribes the inner core in an annular fashion is composed of a tobacco material treated with a burn suppressing agent, and the outer material acts as a substrate for an aerosol forming material. A preferred aerosol forming material is glycerin. An outer paper wrapper circumscribes the length of the smokable rod, and another paper wrapping material also can circumscribe the inner core material. In use, one end of the smokable rod is lit, and the tobacco cut filler of the inner core burns to yield tobacco smoke. The outer material smolders, and hence thermal decomposition products of the outer tobacco material and volatilized aerosol forming material are produced.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: July 13, 2010
    Assignee: R. J. Reynolds Tobacco Company
    Inventors: August Joseph Borschke, Dwayne William Beeson, Sharon Pitts Dunlap, Thomas Albert Perfetti
  • Publication number: 20100166884
    Abstract: A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine, useful for the method and a process for preparing said compositions.
    Type: Application
    Filed: June 20, 2008
    Publication date: July 1, 2010
    Inventors: Aktham Aburub, Marcio Chedid, Thomas Albert Engler, Venkatraghavan Vasudevan
  • Publication number: 20100167952
    Abstract: The present invention provides for compositions, methods and systems for targeted sequence enrichment. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in microarray assays by suppressing secondary capture of non-target nucleic acid sequences.
    Type: Application
    Filed: September 3, 2009
    Publication date: July 1, 2010
    Inventors: Thomas Albert, Jeff Jeddeloh, Bradley Swanson
  • Patent number: 7745118
    Abstract: The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: June 29, 2010
    Assignee: Roche Nimblegen, Inc.
    Inventors: Roland D Green, Steve Smith, Thomas Albert, Emile F. Nuwaysir
  • Publication number: 20100151206
    Abstract: Described herein is a method for removing at least a portion of the carbon-containing species within an organosilicate (OSG) film by treating the OSG film with a chemical, such as but not limited to an oxidizer, exposing the OSG film to an energy source comprising ultraviolet light, or treating the OSG film with a chemical and exposing the OSG film to an energy source.
    Type: Application
    Filed: October 8, 2009
    Publication date: June 17, 2010
    Applicant: Air Products and Chemicals, Inc.
    Inventors: Aiping Wu, Scott Jeffrey Weigel, Thomas Albert Braymer
  • Publication number: 20100004954
    Abstract: Disclosed are systems for underwriting insurance contracts. In one embodiment a system comprises a rules database of business rules specifying one or more conditions based upon one or more underwriting parameters; a user database comprising entries corresponding to registered users; and a processor configured to: provide to the user a form having a plurality of data fields generated based upon the underwriting parameters specified in the business rules; receive a plurality of inputted underwriting parameters corresponding to the data fields; determine whether the inputted underwriting parameters satisfy the business rules; and if at least one of the inputted underwriting parameters does not satisfy the business rules, provide a status message indicating that at least one business rule is not satisfied. The status message can be provided in an interface that includes a graphical element linking a part of the status message with a portion of the displayed form.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 7, 2010
    Applicant: FirstBest Systems, Inc.
    Inventors: Julian E. Pelenur, Paul Thomas Cummings, Joseph Pilkerton, John Belizaire, Kelly Ann Lynch, Jeffrey Jerome Glass, Hao Chen, Thomas Albert Muldoon
  • Publication number: 20100004953
    Abstract: Disclosed are methods of underwriting insurance contracts. In one embodiment a method comprises receiving from a registered user a request for approval of the insurance contract, the request for approval of the insurance contract including underwriting parameters of the insurance contract; reading, from a user database underwriting criteria corresponding to the user; determining whether the underwriting parameters of the insurance contract satisfy the underwriting criteria of the user; and providing an interface including a status message indicating that at least one underwriting criterion is not satisfied, if at least one underwriting criterion is not satisfied. The interface can include a graphical element linking a part of the status message with a displayed parameter of the contract.
    Type: Application
    Filed: July 3, 2008
    Publication date: January 7, 2010
    Applicant: FirstBest Systems, Inc.
    Inventors: Julian E. Pelenur, Paul Thomas Cummings, Joseph Pilkerton, John Belizaire, Kelly Ann Lynch, Jeffrey Jerome Glass, Hao Chen, Thomas Albert Muldoon
  • Patent number: 7636637
    Abstract: The present invention provides novel method for increasing the efficiency and accuracy of high-throughput mutation mapping and genome resequencing by using a variable length probe selection algorithm to rationally select probes used in designing oligonucleotide arrays synthesized by Maskless Array Synthesis (MAS) technology. Also disclosed is a variable length probe selection algorithm used in designing such oligonucleotide arrays.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: December 22, 2009
    Assignee: Roche NimbleGen, Inc.
    Inventors: Thomas Albert, Jason Norton, Roland Green
  • Publication number: 20090298671
    Abstract: Silica-based materials and films having a dielectric constant of 3.7 or below and compositions and methods for making and using same are disclosed herein. In one aspect, there is provided a composition for preparing a silica-based material comprising an at least one silica source, a solvent, an at least one porogen, optionally a catalyst, and optionally a flow additive wherein the solvent boils at a temperature ranging from 90° C. to 170° C. and is selected from the group of compounds represented by the following formulas: HO—CHR8—CHR9—CH2—CHR10R11 where R8, R9, R10 and R11 can independently be an alkyl group ranging from 1 to 4 carbon atoms or a hydrogen atom; and R12—CO—R13 where R12 is a hydrocarbon group having from 3 to 6 carbon atoms; R13 is a hydrocarbon group having from 1 to 3 carbon atoms; and mixtures thereof.
    Type: Application
    Filed: August 10, 2009
    Publication date: December 3, 2009
    Applicant: AIR PRODUCTS AND CHEMICALS, INC.
    Inventors: Scott Jeffrey Weigel, Shrikant Narendra Khot, James Edward Mac Dougall, Thomas Albert Braymer, John Francis Kirner, Brian Keith Peterson
  • Publication number: 20090246788
    Abstract: The present disclosure provides methods and systems for sequence specific nucleic acid target capture comprising enzymatic reactions. The present disclosure relates to a plurality of oligonucleotide probes for capture and subsequent detection of target nucleic acid sequences, using flap endonucleases, ligases, and/or additional enzymes, proteins or compounds, on substrates, for example microarray slides, and in solution formats.
    Type: Application
    Filed: March 20, 2009
    Publication date: October 1, 2009
    Applicant: ROCHE NIMBLEGEN, INC.
    Inventors: Thomas Albert, Jigar Patel, Victor Lyamichev
  • Publication number: 20090221438
    Abstract: The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
    Type: Application
    Filed: February 23, 2009
    Publication date: September 3, 2009
    Applicant: ROCHE NIMBLEGEN, INC.
    Inventors: Jacob Kitzman, Todd Richmond, Mark D'Ascenzo, Thomas Albert, Matthew Rodesch, Jeffrey Jeddeloh, Christina Middle
  • Patent number: 7558873
    Abstract: Method for Internet Protocol Payload Compression (IPComp) and Large Send is described. More particularly, a Large Send initiated by a computer is used to trigger an IPComp negotiation. After agreement on IPComp, data blocks for such a Large Send are compressed in accordance with an agreed upon compression algorithm prior to being divided up into smaller blocks, such as being divided by a maximum transmission unit, for sending. To further improve performance, a intelligent network interface with Large Send and IPComp capabilities is used for offloading Large Send and IPComp functions.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 7, 2009
    Assignee: NVIDIA Corporation
    Inventor: Thomas Albert Maufer
  • Publication number: 20090151739
    Abstract: A smokable rod for a smoking article, such as a cigarette, possesses a co-axial or concentric construction. The outer material that circumscribes the inner core in an annular fashion is composed of a tobacco material treated with a burn suppressing agent, and the outer material acts as a substrate for an aerosol forming material. A preferred aerosol forming material is glycerin. An outer paper wrapper circumscribes the length of the smokable rod, and another paper wrapping material also can circumscribe the inner core material. In use, one end of the smokable rod is lit, and the tobacco cut filler of the inner core burns to yield tobacco smoke. The outer material smolders, and hence thermal decomposition products of the outer tobacco material and volatilized aerosol forming material are produced.
    Type: Application
    Filed: February 24, 2009
    Publication date: June 18, 2009
    Inventors: August Joseph Borschke, Dwayne William Beeson, Sharon Pitts Dunlap, Thomas Albert Perfetti
  • Publication number: 20090141866
    Abstract: A dental x-ray sensor holder includes at least two clamping faces wherein at least one of the faces includes at least one and preferably a plurality of resiliently deformable gripping protrusions. The clamping faces are positioned in a moveable, spaced opposing relation, such that the faces may be physically moved together to physically impinge the x-ray sensor therebetween.
    Type: Application
    Filed: November 30, 2007
    Publication date: June 4, 2009
    Inventors: Lawrence Jon Fenske, Gregory Falendysz, John Aaron Miller, Thomas Albert Sutrina, Cunjiang Cheng, Kimberly Clementz Brown