Abstract: Various fixation techniques for implantable medical device (IMDs) are described. In one example, an assembly comprises an IMD; and a set of active fixation tines attached to the IMD. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the IMD to a hooked position in which the active fixation tines bend back towards the IMD. The active fixation tines are configured to secure the IMD to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

Abstract: A fixation member component, for example, employed by a relatively compact implantable medical device, includes a plurality of fingers; each finger includes a first segment extending from a fixed end of the corresponding finger, and a second segment extending from the corresponding first segment to a free end of the corresponding finger. Each first segment is elastically deformable from a relaxed to an extended condition, and from the relaxed to a compressed condition, and includes a peripheral portion and a central cut-out portion, framed by the peripheral portion. In the compressed condition, a free tip of the cut-out portion of some or all of the fingers may lodge against opposing tissue surfaces, via a spring force of the compressed fingers. Each second segment and cut-out portion is preferably configured to prevent penetration thereof within tissue at the implant site.

Abstract: The present invention relates to a compound of Formula 1, 2 or 3: I II III wherein A is N or —CR0—, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is —CRe—, or, —N—, where Re is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1C6 linear or branched chain alkyl, etc.; R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.

Abstract: An additive manufacturing system for printing three-dimensional parts, the system comprising a heatable region, a receiving surface, a print head configured to print a three-dimensional part onto the receiving surface in a layer-by-layer manner along a printing axis, and a drive mechanism configured to index the receiving surface along the printing axis such that the receiving surface and at least a portion of the three-dimensional part out of the heated region.

Abstract: The invention relates to an air freight container and/or air freight pallet with a flat bottom wall and/or side wall, at least two guide devices arranged on the bottom wall and/or side wall, two connecting elements, wherein a fastening region assigned to a first end of the connecting element in each case extends over part of the connecting element, and a fixing element for fixing an item to be transported transportable by means of the air freight container and/or air freight pallet, wherein the fixing element is connected at the first end thereof to the fastening region of one connecting element and at the second end thereof, which is opposite the first end, is connected to the fastening region of the other connecting element, the connecting elements each have, at a second end arranged opposite the first end, a latching device designed for latching into the corresponding guide device, and at least one guide device is formed in such a way that the latching device can be latched into the guide device at differe

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: A tine portion for an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, has one of: a round cross-section and an elliptical cross-section, while the distal segment has a flattened, or approximately rectangular cross-section. One or a pair of the tine portions may be integrally formed, with a base portion, from a superelastic wire, wherein the base portion is configured to fixedly attach to the device, for example, being captured between insulative members of a fixation subassembly.

Abstract: A fixation member component, for example, employed by a relatively compact implantable medical device, includes a plurality of fingers; each finger includes a first segment extending from a fixed end of the corresponding finger, and a second segment extending from the corresponding first segment to a free end of the corresponding finger. Each first segment is elastically deformable from a relaxed to an extended condition, and from the relaxed to a compressed condition, and includes a peripheral portion and a central cut-out portion, framed by the peripheral portion. In the compressed condition, a free tip of the cut-out portion of some or all of the fingers may lodge against opposing tissue surfaces, via a spring force of the compressed fingers. Each second segment and cut-out portion is preferably configured to prevent penetration thereof within tissue at the implant site.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: An additive manufacturing system for printing three-dimensional parts, the system comprising a heatable region, a receiving surface, a print head configured to print a three-dimensional part onto the receiving surface in a layer-by-layer manner along a printing axis, and a drive mechanism configured to index the receiving surface along the printing axis such that the receiving surface and at least a portion of the three-dimensional part out of the heated region.

Abstract: A tine portion for an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, has one of: a round cross-section and an elliptical cross-section, while the distal segment has a flattened, or approximately rectangular cross-section. One or a pair of the tine portions may be integrally formed, with a base portion, from a superelastic wire, wherein the base portion is configured to fixedly attach to the device, for example, being captured between insulative members of a fixation subassembly.

Abstract: An implantable pacemaker system includes a housing having a proximal end and a distal end. A control electronics subassembly defines the housing proximal end, and a battery subassembly defines the housing distal end. A distal fixation member extends from the housing distal end for fixing the housing distal end at an implant site. A pacing extension extends from the housing proximal end and carries a pacing cathode electrode. The pacing extension extends the pacing cathode electrode to a pacing site that is spaced apart from the implant site when the pacemaker is deployed in a patient's body.

Abstract: A medical device system is configured to sense a physiological signal by a first device and generate a control signal by the first device in response to the physiological signal. An acoustical emitting device is controlled by the first device to emit an acoustical trigger signal in response to the control signal. A second device detects the acoustical trigger signal and delivers an automatic therapy to a patient in response to detecting the acoustical trigger signal.

Abstract: A tethering feature includes an elongate break-away member and a base, and forms a proximal end of an implantable medical device housing. A tether attachment zone of the break-away member extends between break-away member ends, and the base includes a pair of supports, wherein each end of the break-away member is wrapped around a corresponding support. A delivery catheter tether may be attached to the device tethering feature by passing a looped portion of the tether around the tether attachment zone. The device may be untethered from the catheter by applying a pull force through the attached tether, while a distal end of a shaft of the catheter, which abuts the device proximal end, provides a back-up force, the pull force unwrapping each end of break-away member from the corresponding base support.

Abstract: An assembly for tethering a medical device to a delivery catheter includes a tether, a collet, and a spring-biased holding element that is coupled to a distal end of the tether and that extends around the collet, being moveable between first and second positions. At the first position, corresponding to the spring bias thereof, the holding element prevents fingers of the collet, which are configured to grip a proximal end of the device, from opening; at the second position, the collet fingers are allowed and/or caused to open. The assembly is coupled to a tubular member of the catheter, and, when the tethering assembly abuts a distal end of the catheter tubular member, a pull force applied to a proximal end the tether, which extends out from a proximal opening of the catheter, moves the holding element from the first position to the second position.

Abstract: An implantable pacemaker system includes a housing having a proximal end and a distal end. A control electronics subassembly defines the housing proximal end, and a battery subassembly defines the housing distal end. A distal fixation member extends from the housing distal end for fixing the housing distal end at an implant site. A pacing extension extends from the housing proximal end and carries a pacing cathode electrode. The pacing extension extends the pacing cathode electrode to a pacing site that is spaced apart from the implant site when the pacemaker is deployed in a patient's body.

Abstract: A wire bond system. Implementations may include: a bond wire including copper (Cu), a bond pad including aluminum (Al) and a sacrificial anode electrically coupled with the bond pad, where the sacrificial anode includes one or more elements having a standard electrode potential below a standard electrode potential of Al.

Abstract: A tethering feature includes an elongate break-away member and a base, and forms a proximal end of an implantable medical device housing. A tether attachment zone of the break-away member extends between break-away member ends, and the base includes a pair of supports, wherein each end of the break-away member is wrapped around a corresponding support. A delivery catheter tether may be attached to the device tethering feature by passing a looped portion of the tether around the tether attachment zone. The device may be untethered from the catheter by applying a pull force through the attached tether, while a distal end of a shaft of the catheter, which abuts the device proximal end, provides a back-up force, the pull force unwrapping each end of break-away member from the corresponding base support.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.

Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.