Abstract: An apparatus that monitors activity during sleep employs one or more humidity sensors. The apparatus may include a sleeping surface, at least one humidity sensor in association with the sleeping surface, and at least one processor in communication with the at least one humidity sensor. The apparatus may monitor a humidity at the sleeping surface over a duration of time to determine one or more of a presence of an individual on the sleeping surface, a position of the individual on the sleeping surface, and/or movement by the individual on the sleeping surface, as well as a type of movement by the individual (e.g., a normal change in position, movement indicative of restless sleep, etc.). The apparatus may control adjustment of one or more characteristics of a cushion with which the sleeping surface is associated based on a type of movement detected and determined by the apparatus. Methods for monitoring activity during sleep and, optionally, adjusting the sleeping surface are also disclosed.

Abstract: In some examples, unstructured data is evaluated using a natural language processing model to output a set of subjective indicators. These subjective indicators are scored using a predictive model to determine whether a dependent user has or is likely to develop a particular condition such as a cellular abnormality.

Abstract: A coupling device for a small scale railway vehicle includes two shanks, a coil spring, and a spring prop. Each shank has coupling and lever ends, and is mounted on a pivot post for selectively pivoting, in opposite directions, between open and closed configurations. When open, the coupling ends are splayed apart for selective coupling to a second coupler. Any load borne by the coupling ends, from the second coupler, is transferred via the pivot post to the railway vehicle. The coil spring extends between the lever ends. It is biased towards the closed configuration. The spring prop partially bisects the coil spring and, via the coil spring, urges the shanks towards the closed configuration and the coupling ends, in opposing transverse directions, towards a centered position for secure coupling engagement with the second coupler.

Abstract: Articles and methods related to multilayered media are generally provided. Some embodiments are generally related to filter media. Some embodiments relate to multilayered media comprising an irregular structure. The irregular structure may be present on an external surface of the multilayered media, in the interior of the multilayered media, and/or throughout the multilayered media. Some aspects are generally related to multilayered media that are reversibly stretchable and/or comprising a polymeric film.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: An acoustic field may be produced from a transducer array having known relative positions and orientations In this acoustic field, one or more control points may be defined. An amplitude may be assigned to the control point. Mid-air haptic effect for a virtual object on a human body part may be generated by moving the control point in a single closed curve comprising a plurality of curve segments. The single closed curve traverses at least one location where the human body part intersects with the virtual object. Additionally, a user may interact with virtual three-dimensional content using the user's hands while a tracking system monitoring the user's hands, a physics engine updates the properties of the virtual three-dimensional content and a haptic feedback system provides haptic information to the user.

Abstract: A system providing various improved calibration techniques for haptic feedback is described. An acoustic field is defined by one or more control points in a space within which the acoustic field may exist. Each control point is assigned an amplitude value equating to a desired amplitude of the acoustic field at the control point. Because complete control of space is not possible, controlling the acoustic field at given points yields erroneous local maxima in the acoustic field levels at other related positions. In relation to mid-air haptic feedback, these can interfere in interactions with the space by creating secondary effects and ghost phenomena that can be felt outside the interaction area. The level and nature of the secondary maxima in the acoustic field is determined by how the space is controlled. By arranging the transducer elements in different ways, unwanted effects on the acoustic field can be limited and controlled.

Abstract: A position locking apparatus for a seat includes a track, a lock housing, a piston, a shaft, and a cam. The track has track teeth. The lock housing has a slot. The piston has piston teeth on a first distal end, which is configured to slide in the slot. The cam is attached to the shaft and the shaft pivotably couples with the lock housing. The cam is configured to contact a second distal end of the piston to press the piston towards the track such that the piston teeth engage with the track teeth to lock a position of the track relative to the piston and the lock housing in response to the cam being pivoted in a first angular direction via the shaft.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Abstract: The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is selected from the group consisting of: a polypeptide, a carbohydrate, a polynucleotide and combinations thereof. The present invention further relates to a method for production of encapsulated antigens in a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention. The present invention also relates to vaccines comprising polymersomes of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: A process and system provides for atraumatic preparation of morcelized Tissue Particles (MTPs), such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The MTPs may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: According to an aspect, an implantable device includes a fluid reservoir configured to be implanted in a body of a patient at a first location, an inflatable member configured to be implanted in the body of the patient at a second location, and a pump assembly configured to be implanted in the body of the patient at a third location. The pump assembly is configured to transfer fluid from the fluid reservoir to the inflatable member in response to the implantable device being in an inflation mode, and the pump assembly configured to transfer the fluid from the inflatable member to the fluid reservoir in response to the implantable device being in a deflation mode. The pump assembly includes an electronic control module, an electronically powered pump, a first valve, and a second valve. The electronic control module is configured to activate or deactivate the electronically powered pump.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises, during an ultrasound scan, acquiring a series of ultrasound frames with a first transmit power, receiving a command to pause the ultrasound scan, and acquiring at least one ultrasound frame with a second transmit power higher than the first transmit power responsive to receiving the command. In this way, the image quality of an image displayed while a scan is paused may be increased.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: A system and method for teaching a robot program based on user input. In some embodiments, poses of a posing device manipulated by a user are captured and analyzed. In some embodiments, robot instructions are determined by a machine-learning algorithm that is trained on data concerning previously executed instructions evaluated by a user. In some embodiments, a user-selected process type defines workpiece geometry types for guiding the creation of robot instructions. In some embodiments, an augmented- or virtual-reality user interface is provided for obtaining user input.

Abstract: A bead for releasably securing a glazing unit to a frame member, comprising a body having a first end and a second end, and a resiliently deformable member secured to the body and having a first finger extending from the body to a first end, and a second finger extending from the first finger to a second end. The first end of the body and the first end of the first finger are configured to engage with respective first and second ends of a frame member so as to secure the bead to the frame member. The second end of the body is configured to secure a glazing unit against an opposed seal of the frame member. The body comprises a first material having a first stiffness and the deformable member comprises a second material having a second stiffness less than the first stiffness.

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.