Abstract: According to an aspect, an implantable device includes a fluid reservoir configured to be implanted in a body of a patient at a first location, an inflatable member configured to be implanted in the body of the patient at a second location, and a pump assembly configured to be implanted in the body of the patient at a third location. The pump assembly is configured to transfer fluid from the fluid reservoir to the inflatable member in response to the implantable device being in an inflation mode, and the pump assembly configured to transfer the fluid from the inflatable member to the fluid reservoir in response to the implantable device being in a deflation mode. The pump assembly includes an electronic control module, an electronically powered pump, a first valve, and a second valve. The electronic control module is configured to activate or deactivate the electronically powered pump.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises, during an ultrasound scan, acquiring a series of ultrasound frames with a first transmit power, receiving a command to pause the ultrasound scan, and acquiring at least one ultrasound frame with a second transmit power higher than the first transmit power responsive to receiving the command. In this way, the image quality of an image displayed while a scan is paused may be increased.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: A system and method for teaching a robot program based on user input. In some embodiments, poses of a posing device manipulated by a user are captured and analyzed. In some embodiments, robot instructions are determined by a machine-learning algorithm that is trained on data concerning previously executed instructions evaluated by a user. In some embodiments, a user-selected process type defines workpiece geometry types for guiding the creation of robot instructions. In some embodiments, an augmented- or virtual-reality user interface is provided for obtaining user input.

Abstract: A bead for releasably securing a glazing unit to a frame member, comprising a body having a first end and a second end, and a resiliently deformable member secured to the body and having a first finger extending from the body to a first end, and a second finger extending from the first finger to a second end. The first end of the body and the first end of the first finger are configured to engage with respective first and second ends of a frame member so as to secure the bead to the frame member. The second end of the body is configured to secure a glazing unit against an opposed seal of the frame member. The body comprises a first material having a first stiffness and the deformable member comprises a second material having a second stiffness less than the first stiffness.

Abstract: A differentially tightenable ski boot includes a lower shell and an upper cuff that is pivotally coupled with the lower shell. The ski boot includes a first tightening system that is coupled with the lower shell and a second tightening system that is coupled with the upper cuff. Each tightening system includes a reel based closure device, a tension member that is operably coupled with the reel based closure device, and at least one guide member that routes or directs the tension member along a path about the lower shell or upper cuff. The first tightening system and the second tightening system are operable independently of each other to independently and differentially tightening the lower shell and the upper cuff.

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.

Abstract: Packaging methods include inserting an article into a virtual pouch defined by folding and tacking a first sheet of textile material. The first sheet is then folded about the article such that the first sheet encompasses the article. A second sheet of a textile material is then folded about the first sheet into a configuration such that the second sheet entirely envelops and encloses the first sheet and the textile article. The second folded sheet is then secured in the enveloping configuration. Alternatively, the article is wrapped in and encompassed by a first sheet of textile material by folding and the resulting package is then enclosed within a virtual pouch created in a second sheet of textile material. The resulting outer sheet enclosing the inner sheet with the textile article is then secured in its enclosing configuration with a strap. The packaging materials can be cleaned and decontaminated for reuse.

Abstract: Packaging methods include inserting an article into a virtual pouch defined by folding and tacking a first sheet of textile material. The first sheet is then folded about the article such that the first sheet encompasses the article. A second sheet of a textile material is then folded about the first sheet into a configuration such that the second sheet entirely envelops and encloses the first sheet and the textile article. The second folded sheet is then secured in the enveloping configuration. Alternatively, the article is wrapped in and encompassed by a first sheet of textile material by folding and the resulting package is then enclosed within a virtual pouch created in a second sheet of textile material. The resulting outer sheet enclosing the inner sheet with the textile article is then secured in its enclosing configuration with a strap. The packaging materials can be cleaned and decontaminated for reuse.

Abstract: A process and system provides for atraumatic preparation of morcelized Tissue Particles (MTPs), such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The MTPs may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: The present application describes injection molding machines and, more particularly, a removable nozzle tip and nozzle assembly for use with an injection molding machine and an engagement tool and methods for replacing a nozzle tip. In an aspect, an injection molding machine may include a nozzle. The nozzle may include a nozzle housing and a nozzle tip threadably attached to the nozzle housing. At least a portion of an exterior wall of the nozzle housing and at least a portion of an exterior wall of the nozzle tip may align to provide a cylindrical surface. The injection molding machine may further include a tubular heater enclosing at least a portion of the continuous cylindrical surface. The nozzle tip does not include a torque feature in any location that is downstream of the tubular heater and upstream of a mold gate of the nozzle.

Abstract: The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is selected from the group consisting of: a polypeptide, a carbohydrate, a polynucleotide and combinations thereof. The present invention further relates to a method for production of encapsulated antigens in a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention. The present invention also relates to vaccines comprising polymersomes of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: Embodiments described herein relate to systems and methods for automatically generating content, generating API requests and/or request bodies, structuring user-generated content, and/or generating structured content in collaboration platforms, such as documentation systems, issue tracking systems, project management platforms, and other platforms. The systems and methods described use a network architecture that includes a prompt generation service and a set of one or more purpose-configured large language model instances (LLMs) and/or other trained classifiers or natural language processors used to provide generative responses for content collaboration platforms.

Abstract: A method for positioning an input device of a workstation for use by a seated user in controlling a robotic surgery system is disclosed. The input device is operable to generate input signals representing a position of a hand controller moveable within an input device workspace. The method involves determining a vertical position of the hand controller within the input device workspace for an input signal received from the input device while a seated user's hand is grasping the hand controller in an initialization position defined with respect to the user's body. The method also involves determining a user ergonomic height of the input device based on the vertical position of the hand controller at the initialization position, and causing a platform of the workstation on which the input device is mounted to move vertically with respect to a base of the workstation to position the input device at the ergonomic height.

Abstract: A package comprises a sterilized, reusable textile item comprising a textile material; a reusable bag comprising a sterilized textile material defining an interior cargo space in which the sterilized textile item is contained; a reusable envelope comprising a folded, sheet of sterilized textile material by which the bag containing the sterilized textile item is entirely enveloped; and a reusable tie comprising an elongate length of a sterilized textile material extending around and securing the envelope onto the bag. A method comprises inserting the textile item into the bag; folding the sheet about the bag; and securing the folded sheet enveloping the bag using the tie. All four components are reusable of the packaging including the textile item. The package preferably constitutes mono material packaging.

Abstract: Described herein are techniques for tracking objects (including human body parts such as a hand), namely: 1) two-state transducer interpolation in acoustic phased-arrays; 2) modulation techniques in acoustic phased-arrays; 3) fast acoustic full matrix capture during haptic effects; 4) time-of-flight depth sensor fusion system; 5) phase modulated spherical wave-fronts in acoustic phased-arrays; 6) long wavelength phase modulation of acoustic field for location and tracking; and 7) camera calibration through ultrasonic range sensing.

Abstract: An apparatus, system, and method for determining a source of contaminants in air. The apparatus includes a plurality of sensors configured to generate raw sampling data of the air. The raw sampling data can describe at least two characteristics of the contaminants in the air. The apparatus also includes memory storing instructions and a processor communicatively coupled to the set of sensors and the memory, the processor configured to execute the instructions to cause the apparatus to identify one or more occurrences of a contamination event based on a comparison of the a characteristic and a detection threshold for the first characteristic of the contaminants in the air; and for each of the one or more occurrences of the contamination event, generate a data entry including a second characteristic. The second characteristic is usable to determine the source of the contaminants in the air.

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.