Abstract: A position locking apparatus for a seat includes a track, a lock housing, a piston, a shaft, and a cam. The track has track teeth. The lock housing has a slot. The piston has piston teeth on a first distal end, which is configured to slide in the slot. The cam is attached to the shaft and the shaft pivotably couples with the lock housing. The cam is configured to contact a second distal end of the piston to press the piston towards the track such that the piston teeth engage with the track teeth to lock a position of the track relative to the piston and the lock housing in response to the cam being pivoted in a first angular direction via the shaft.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Abstract: A process and system provides for atraumatic preparation of morcelized Tissue Particles (MTPs), such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The MTPs may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: According to an aspect, an implantable device includes a fluid reservoir configured to be implanted in a body of a patient at a first location, an inflatable member configured to be implanted in the body of the patient at a second location, and a pump assembly configured to be implanted in the body of the patient at a third location. The pump assembly is configured to transfer fluid from the fluid reservoir to the inflatable member in response to the implantable device being in an inflation mode, and the pump assembly configured to transfer the fluid from the inflatable member to the fluid reservoir in response to the implantable device being in a deflation mode. The pump assembly includes an electronic control module, an electronically powered pump, a first valve, and a second valve. The electronic control module is configured to activate or deactivate the electronically powered pump.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises, during an ultrasound scan, acquiring a series of ultrasound frames with a first transmit power, receiving a command to pause the ultrasound scan, and acquiring at least one ultrasound frame with a second transmit power higher than the first transmit power responsive to receiving the command. In this way, the image quality of an image displayed while a scan is paused may be increased.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: A system and method for teaching a robot program based on user input. In some embodiments, poses of a posing device manipulated by a user are captured and analyzed. In some embodiments, robot instructions are determined by a machine-learning algorithm that is trained on data concerning previously executed instructions evaluated by a user. In some embodiments, a user-selected process type defines workpiece geometry types for guiding the creation of robot instructions. In some embodiments, an augmented- or virtual-reality user interface is provided for obtaining user input.

Abstract: A bead for releasably securing a glazing unit to a frame member, comprising a body having a first end and a second end, and a resiliently deformable member secured to the body and having a first finger extending from the body to a first end, and a second finger extending from the first finger to a second end. The first end of the body and the first end of the first finger are configured to engage with respective first and second ends of a frame member so as to secure the bead to the frame member. The second end of the body is configured to secure a glazing unit against an opposed seal of the frame member. The body comprises a first material having a first stiffness and the deformable member comprises a second material having a second stiffness less than the first stiffness.

Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.

Abstract: A differentially tightenable ski boot includes a lower shell and an upper cuff that is pivotally coupled with the lower shell. The ski boot includes a first tightening system that is coupled with the lower shell and a second tightening system that is coupled with the upper cuff. Each tightening system includes a reel based closure device, a tension member that is operably coupled with the reel based closure device, and at least one guide member that routes or directs the tension member along a path about the lower shell or upper cuff. The first tightening system and the second tightening system are operable independently of each other to independently and differentially tightening the lower shell and the upper cuff.

Abstract: Packaging methods include inserting an article into a virtual pouch defined by folding and tacking a first sheet of textile material. The first sheet is then folded about the article such that the first sheet encompasses the article. A second sheet of a textile material is then folded about the first sheet into a configuration such that the second sheet entirely envelops and encloses the first sheet and the textile article. The second folded sheet is then secured in the enveloping configuration. Alternatively, the article is wrapped in and encompassed by a first sheet of textile material by folding and the resulting package is then enclosed within a virtual pouch created in a second sheet of textile material. The resulting outer sheet enclosing the inner sheet with the textile article is then secured in its enclosing configuration with a strap. The packaging materials can be cleaned and decontaminated for reuse.

Abstract: Packaging methods include inserting an article into a virtual pouch defined by folding and tacking a first sheet of textile material. The first sheet is then folded about the article such that the first sheet encompasses the article. A second sheet of a textile material is then folded about the first sheet into a configuration such that the second sheet entirely envelops and encloses the first sheet and the textile article. The second folded sheet is then secured in the enveloping configuration. Alternatively, the article is wrapped in and encompassed by a first sheet of textile material by folding and the resulting package is then enclosed within a virtual pouch created in a second sheet of textile material. The resulting outer sheet enclosing the inner sheet with the textile article is then secured in its enclosing configuration with a strap. The packaging materials can be cleaned and decontaminated for reuse.

Abstract: A process and system provides for atraumatic preparation of morcelized Tissue Particles (MTPs), such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The MTPs may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: The present application describes injection molding machines and, more particularly, a removable nozzle tip and nozzle assembly for use with an injection molding machine and an engagement tool and methods for replacing a nozzle tip. In an aspect, an injection molding machine may include a nozzle. The nozzle may include a nozzle housing and a nozzle tip threadably attached to the nozzle housing. At least a portion of an exterior wall of the nozzle housing and at least a portion of an exterior wall of the nozzle tip may align to provide a cylindrical surface. The injection molding machine may further include a tubular heater enclosing at least a portion of the continuous cylindrical surface. The nozzle tip does not include a torque feature in any location that is downstream of the tubular heater and upstream of a mold gate of the nozzle.

Abstract: The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is selected from the group consisting of: a polypeptide, a carbohydrate, a polynucleotide and combinations thereof. The present invention further relates to a method for production of encapsulated antigens in a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention. The present invention also relates to vaccines comprising polymersomes of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: Embodiments described herein relate to systems and methods for automatically generating content, generating API requests and/or request bodies, structuring user-generated content, and/or generating structured content in collaboration platforms, such as documentation systems, issue tracking systems, project management platforms, and other platforms. The systems and methods described use a network architecture that includes a prompt generation service and a set of one or more purpose-configured large language model instances (LLMs) and/or other trained classifiers or natural language processors used to provide generative responses for content collaboration platforms.

Abstract: A method for positioning an input device of a workstation for use by a seated user in controlling a robotic surgery system is disclosed. The input device is operable to generate input signals representing a position of a hand controller moveable within an input device workspace. The method involves determining a vertical position of the hand controller within the input device workspace for an input signal received from the input device while a seated user's hand is grasping the hand controller in an initialization position defined with respect to the user's body. The method also involves determining a user ergonomic height of the input device based on the vertical position of the hand controller at the initialization position, and causing a platform of the workstation on which the input device is mounted to move vertically with respect to a base of the workstation to position the input device at the ergonomic height.