Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.

Abstract: Aspects of the present disclosure address improved systems and methods for generating a clock tree based on route-driven placement of fan-out clock drivers. Consistent with some embodiments, a method may include constructing a spanning tree comprising one or more paths that interconnect a set of clock sinks of a clock net of an integrated circuit device design. The method further includes calculating a center of the set of the clock sinks based on clock sink locations in the integrated circuit device design and identifying a point on the spanning tree nearest to the center of the set of clock sinks. The method further includes generating a clock tree by placing a clock driver at the point on the spanning tree that is nearest to the center of the set of clock sinks.

Abstract: A differentially tightenable ski boot includes a lower shell and an upper cuff that is pivotally coupled with the lower shell. The ski boot includes a first tightening system that is coupled with the lower shell and a second tightening system that is coupled with the upper cuff. Each tightening system includes a reel based closure device, a tension member that is operably coupled with the reel based closure device, and at least one guide member that routes or directs the tension member along a path about the lower shell or upper cuff. The first tightening system and the second tightening system are operable independently of each other to independently and differentially tightening the lower shell and the upper cuff.

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

Abstract: Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Abstract: According to an aspect, an implantable device includes a fluid reservoir configured to be implanted in a body of a patient at a first location, an inflatable member configured to be implanted in the body of the patient at a second location, and a pump assembly configured to be implanted in the body of the patient at a third location. The pump assembly is configured to transfer fluid from the fluid reservoir to the inflatable member in response to the implantable device being in an inflation mode, and the pump assembly configured to transfer the fluid from the inflatable member to the fluid reservoir in response to the implantable device being in a deflation mode. The pump assembly includes an electronic control module, an electronically powered pump, a first valve, and a second valve. The electronic control module is configured to activate or deactivate the electronically powered pump.

Abstract: Described is a method for instilling the haptic dimension of texture to virtual and holographic objects using mid-air ultrasonic technology. A set of features is extracted from imported images using their associated displacement maps. Textural qualities such as the micro and macro roughness are then computed and fed to a haptic mapping function together with information about the dynamic motion of the user's hands during holographic touch. Mid-air haptic textures are then synthesized and projected onto the user's bare hands. Further, mid-air haptic technology enables tactile exploration of virtual objects in digital environments. When a user's prior and current expectations and rendered tactile texture differ, user immersion can break. A study aims at mitigating this by integrating user expectations into the rendering algorithm of mid-air haptic textures and establishes a relationship between visual and mid-air haptic roughness.

Abstract: Various methods and systems are provided for ultrasound imaging. In one embodiment, a method comprises, during an ultrasound scan, acquiring a series of ultrasound frames with a first transmit power, receiving a command to pause the ultrasound scan, and acquiring at least one ultrasound frame with a second transmit power higher than the first transmit power responsive to receiving the command. In this way, the image quality of an image displayed while a scan is paused may be increased.

Abstract: A system providing various improved processing techniques for haptic feedback is described. An acoustic field is defined by one or more control points in a space within which the acoustic field may exist. Each control point is assigned an amplitude value equating to a desired amplitude of the acoustic field at the control point. Transducers are then controlled to create an acoustic field exhibiting the desired amplitude at each of the control points. When human skin interacts with the acoustic field, vibrations of the skin are interpreted by mechanoreceptors being excited and sending signals to the brain via the nervous system. Improved processing techniques allow for more efficient real-world operation.

Abstract: In some examples, systems, methods, and devices are described that generate contextual suggestions for patients. Generation of the contextual suggestions is triggered by certain events performed by a medical professional with respect to a patient (e.g., updating a patient record). The contextual suggestions are related to addressing health conditions of the patient and represent tasks or considerations which the medical professional should be made aware. The contextual suggestions are generated in a way that is considerate of patient context, medical professional context, and contexts of similar patients. The contextual suggestions can be presented to the medical professional for selection and execution.

Abstract: A method in an intermediate server of initiating updates to a secondary database based on activity in a primary database includes: retrieving primary data from a primary server hosting the primary database; retrieving secondary data from a secondary server hosting the secondary database; storing a combined data set including the primary data and the secondary data; responsive to receiving a request from a client device, presenting a portion of the combined data set to the client device; receiving, from the client device, input data associated with the portion of the combined data set and updating the combined data set in the memory; determining whether to synchronize the updated combined data set with at least one of the primary server and the secondary server; and when the determination is affirmative, selecting a subset of the combined data set for transmission to at least one of the primary and secondary servers.

Abstract: A system and method for workload forecasting and distribution is provided. The method includes obtaining, from a docketing database of the docketing system, active term data defining active terms. The active terms represent action items in the docketing system. The method further includes selecting a subset of the active terms based on the active term data. The method further includes obtaining, from the docketing database, price data associated with the active terms in the subset. The price data represents a cost of performing the action items associated with the active terms. The method further includes generating a predicted cost total based on the price data. The method further includes outputting the predicted cost total.

Abstract: In some examples, structured and unstructured data is analyzed to determine whether a user is at risk for a certain condition. The results of this analysis can be included in a risk assessment. In some examples, structured and unstructured data is analyzed to determine whether a particular event has taken place. Once detection of occurrence of the event has taken place, a notification is generated that a correct recipient is identified. In addition, it is determined if and how the notification should be escalated.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid between the fluid reservoir and the inflatable member. The pump assembly includes a valve body, a pump bulb, and a deflation mode actuator. The valve body includes a bi-directional valve configured to move from an inflation position to a deflation position in response to an activation of the deflation mode actuator. The bi-directional valve in the inflation position is configured to open a fluid passageway in the valve body to transfer fluid from the pump bulb to the inflatable member. The bi-directional valve in the deflation position is configured to open a fluid passageway in the valve body to transfer fluid from the inflatable member to the fluid reservoir that bypasses the pump bulb.

Abstract: In some examples, a suggestion engine is provided to generate decision support output (DSO) based on data collected generation devices within a network. The DSO may be based on dependent users details, profile information for an authorized user associated with the dependent user, one or more knowledge artifacts, and/or other information related to a relationship between the dependent user and the authorized user. The DSO may include one or more suggestions, tasks, considerations, or the like. These may be presented in a customizable contextual user interface which presents DSO in a manner that considers the underlying context in which the dependent user exists. Based on a selection of a task or suggestion, a populator engine may populate one or more forms, which may be approved and provided to other authorized users. In addition, certain analytics data may be organized according to a performance indicator and included within a dashboard, which may be included in the contextual user interface.

Abstract: Described herein are aerosol-free vessels, delivery containers, systems and methods using same for providing improvements to precursor utilization in the containers for deposition process, as well as the cleaning and refilling of the containers. The clogging of valves and piping as some precursors decompose vapor are minimized. This invention prevents mist from forming and thus preventing clogging or wafer contamination from aerosols.

Abstract: Various methods and systems are provided for compensating for motion in medical images. As one example, a method for a medical imaging system may include independently tracking motion of a first object and motion of a second object across a plurality of image frames acquired with the medical imaging system, and for a selected image frame of the plurality of image frames, compensating the selected image frame for the motion of the first object and for the motion of the second object to generate a compensated selected image frame and outputting the compensated selected image frame for display on a display device, where the compensation for the motion of the first object is performed independently of the compensation for the motion of the second object.

Abstract: An acoustic field may be produced from a transducer array having known relative positions and orientations in this acoustic field, one or more control points may be defined. An amplitude may be assigned to the control point. Mid-air haptic effect for a virtual object on a human body part may be generated by moving the control point in a single closed curve comprising a plurality of curve segments. The single closed curve traverses at least one location where the human body part intersects with the virtual object. Additionally, a user may interact with virtual three-dimensional content using the user's hands while a tracking system monitoring the user's hands, a physics engine updates the properties of the virtual three-dimensional content and a haptic feedback system provides haptic information to the user.

Abstract: Provided herein are compounds that are useful in the treatment of pain in a subject.