Abstract: The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is selected from the group consisting of: a polypeptide, a carbohydrate, a polynucleotide and combinations thereof. The present invention further relates to a method for production of encapsulated antigens in a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention. The present invention also relates to vaccines comprising polymersomes of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: In some examples, unstructured data is evaluated using a natural language processing model to output a set of subjective indicators. These subjective indicators are scored using a predictive model to determine whether a dependent user has or is likely to develop a particular condition such as a cellular abnormality.

Abstract: A method for positioning an input device of a workstation for use by a seated user in controlling a robotic surgery system is disclosed. The input device is operable to generate input signals representing a position of a hand controller moveable within an input device workspace. The method involves determining a vertical position of the hand controller within the input device workspace for an input signal received from the input device while a seated user's hand is grasping the hand controller in an initialization position defined with respect to the user's body. The method also involves determining a user ergonomic height of the input device based on the vertical position of the hand controller at the initialization position, and causing a platform of the workstation on which the input device is mounted to move vertically with respect to a base of the workstation to position the input device at the ergonomic height.

Abstract: A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: Disclosed is a system for monitoring the water level proximate to a vehicle. The system comprises a control unit and at least one sensor in communication with the control unit. The at least one sensor is configured such that the control unit can determine a pitch of a trailer coupled to the vehicle and the height of a surface of water proximate to the trailer. The system includes a display screen displaying a representation of the trailer including the pitch of the trailer, and a representation of the surface of water proximate to the trailer.

Abstract: A variety of hexacoordinate pincer complexes are described herein having electronic structure advantageous for electronic and/or optoelectronic applications. In some embodiments, the pincer complexes are luminescent, exhibiting fluorescence and/or phosphorescence. Briefly, a hexacoordinate complex comprises a central atom selected from the group consisting of silicon, germanium, and tin, and two pincer ligands bound to the central atom, wherein the hexacoordinate complex is luminescent. In another aspect, a hexacoordinate complex comprises a central atom selected from the group consisting of silicon, germanium and tin, and two pincer ligands bound to the central atom, wherein the difference between the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of the hexacoordinate complex is at least 1.5 eV.

Abstract: A bead for releasably securing a glazing unit to a frame member, comprising a body having a first end and a second end, and a resiliently deformable member secured to the body and having a first finger extending from the body to a first end, and a second finger extending from the first finger to a second end. The first end of the body and the first end of the first finger are configured to engage with respective first and second ends of a frame member so as to secure the bead to the frame member. The second end of the body is configured to releasably secure a gasket in a first position so as to secure a glazing unit against an opposed end of the frame member.

Abstract: A tightening device for tightening an article includes an elongate panel that is positionable about the article. The elongate panel has a proximal end and a distal end. A tensioning mechanism is coupled with the proximal end of the elongate panel. The tightening device also includes a tension member that is operably coupled with the tensioning mechanism so that an operation of the tensioning mechanism adjusts a tension of the tension member. The tightening device further includes at least one guide member that is coupled with the elongate panel between the proximal end and the distal end. The tension member is operable with the at least one guide member so that the tension member is routed about the article and along a portion of the elongate panel.

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

Abstract: A system providing various improved perceptions techniques for haptic feedback above interactive surfaces that require no contact with either tools, attachments or the surface itself is described. A range of receptors in a perceiving member which is part of the human body is identified to create substantially uniformly perceivable feedback. A vibration frequency that is in the range of the receptors in the perceiving member is chosen and dynamically altered to create substantially uniformly perceivable feedback throughout the receiving member.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

Abstract: Providing express memory obsolescence in processor-based devices is disclosed. In this regard, an instruction set architecture (ISA) of a processor-based device provides a memory load instruction indicating a final memory load operation from a memory address (i.e., after the memory load operation represented by the memory load instruction is performed, the value at the memory address need not be maintained). Upon receiving the memory load instruction by an execution pipeline of the processor-based device, an entry corresponding to the memory address of the memory load instruction is located in an intermediate memory external to the system memory of the processor-based device, and used to perform the final memory load operation. After the final memory load operation is performed using the entry, a value of an obsolete indicator for the entry is set to indicate that the entry can be reused prior to its contents being written to the system memory.

Abstract: The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products and that is stable for commercial use.

Abstract: An automated data entry system comprising target database servers for storing target database(s), a processing server configured to execute a client-application and configured to store a plurality of data objects including a document schema and a target database schema corresponding to the target database(s), and a client terminal connected to the processing server, configured to: generate a first graphical interface for connection to a target database, and to execute a second graphical interface for connection to the client-application. The processing server may also receive an electronic data file representing an unprocessed document, to associate the unprocessed document with a document schema and extract a data variable based on the document schema, and to generate a database operation comprising the data variable configured according to a target database schema.

Abstract: Obsoleting values stored in registers in a processor based on processing obsolescent register-encoded instructions is disclosed. The processor is configured to support execution of read and/or write instructions that include obsolescence encoding indicating that one or more of its source and/or target register operands are to be obsoleted by the processor. A register encoded as obsolescent means the data value stored in such register will not be used by subsequent instructions in an instruction stream, and thus does not need to be retained. Thus, such register can be set as being in an obsolescent state so that the data value stored in such register can be ignored to improve performance. As one example, data values for registers having an obsolescent state can be ignored and thus not stored in a saved context for a process being switched out, thus conserving memory and improving processing time for a process switch.

Abstract: A method for positioning an input device of a workstation for use by a seated user in controlling a robotic surgery system is disclosed. The input device is operable to generate input signals representing a position of a hand controller moveable within an input device workspace. The method involves determining a vertical position of the hand controller within the input device workspace for an input signal received from the input device while a seated user's hand is grasping the hand controller in an initialization position defined with respect to the user's body. The method also involves determining a user ergonomic height of the input device based on the vertical position of the hand controller at the initialization position, and causing a platform of the workstation on which the input device is mounted to move vertically with respect to a base of the workstation to position the input device at the ergonomic height.

Abstract: A method of purchasing tires includes providing a web site stored on a web server accessible from a computing device. The web site displays a page for a consumer, including instructions for locating a placard containing tire information, a request to take a photo of the placard and a request to upload the photo. Once the photo is uploaded, it is stored on the web server. An optical character recognition program is in communication with the web server and is used to analyze the photo. Characters in the photo corresponding to tire size information on the placard are identified. The identified tire size information is correlated in a database to a listing of pre-stored tire information to verify whether the identified tire size information is appropriate for the vehicle. A message is returned to the web site from the web server including the results of the identification and correlation.

Abstract: A method in job processing server of processing database updates includes: storing, at a job processing server, a job queue including a plurality of job records, each job record having corresponding job parameters; detecting job initiation data at a data source; responsive to detecting the job initiation data, retrieving new job parameters from the data source based on the job initiation data; creating a new job record including the new job parameters in the job queue; and responsive to a predefined trigger, for each job in the job queue, processing the job based on corresponding job parameters, wherein processing the job includes sending instructions for execution by a second server, the instructions for performing an update at the second server.