Abstract: The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.

Abstract: An extrusion head having a perforated plate of a granulating system. The extrusion head can have a head part and a perforated plate with a perforated-plate wear insert, a perforated-plate main body, a central inflow cone, an inflow cone part, a plurality of nozzle channels, a plurality of perforated dies, and at least one corrosion protected fastener. The perforated-plate can be detachably fastened to the head part. The head part can have at least one central melt channel into which the inflow cone part projects and distributes a melt flow among nozzle channels which can be arranged in the shape of a ring and among the perforated dies which can be arranged in at least one ring. The at least one fastener can be positioned in a central region of the at least one ring of the perforated dies.

Abstract: The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.

Abstract: A medical injection device has a syringe. The syringe has a container for the medium to be injected and an injection cannula, which communicates with the container. A needle guard of the injection device can be moved between an injection position and a safe position. In the injection position, the injection cannula can be uncovered in order to inject the medium. In the safe position, a cannula tip of the injection cannula is recessed in a protective component of the needle guard. A securing device securely fixes the protective component in the safe position. The result is an injection device having a needle guard that can be manipulated intuitively and operated safely.

Abstract: A test unit for testing a plurality of communications devices is provided. The test unit comprises a test case database, which stores a first test case (including a first test case idle time) and a second test case. The second test case is shorter than the first test case idle time. The test unit comprises a signaling unit. The test unit comprises a test case execution manager, which reads from the test case database the first and second test case and controls the signaling unit to perform measurements according to the first test case on the first device under test until a beginning of the first test case idle time, and controls the signaling unit to perform measurements according to the second test case on the second device under test during the first test case idle time.

Abstract: Method for preparing a sample, wherein the sample is provided as a thin film on a support structure; the temperature of the support structure is adjusted to a value above the dew point temperature of the environment to decrease the film thickness, light is directed at the support structure, an intensity value of the transmitted light is measured, and the support structure is automatically inserted into a liquid cryogen dependent on the measured intensity value. The application further relates to a system comprising a support structure, a temperature-controlled stage for keeping the support structure at a pre-defined temperature, a transfer mechanism for moving the support structure into a container containing a liquid cryogen, a light source, a photodetector for measuring an intensity value of the transmitted light, and a control device for triggering the transfer mechanism dependent on the measured intensity value.

Abstract: A medical injection device has an injection unit and an anti-rotation device. Said anti-rotation device is non-rotationally connected to a port and connection portion of the injection device so as to surround the outside thereof in the manner of a sleeve. As a result, an intuitively usable and operationally safe injection device is obtained. When a protective cap for an injection cannula of the injection unit is being removed from the port and connection portion, an unwanted rotation of the port and connection portion relative to the container about components of a plug-in connection arranged therebetween is safely prevented.

Abstract: A system simulator for simulating a wireless system for testing a wireless device under test comprises an uplink signal receiver for receiving an uplink signal generated by the wireless device under test and providing data blocks embedded in the uplink signal, and an uplink signal impairment unit that based on a predetermined probability value sets the data blocks provided by the uplink signal receiver as valid or erroneously received.

Abstract: The invention relates to a preparation system for preparing a sample for electron microscopy, comprising:—a liquid handling system (0) comprising a dispensing head (1), wherein said liquid handling system (0) is configured to aspirate and dispense a volume of a sample via the dispensing head (1),—a support structure (2) that is configured to accommodate the sample, a temperature-controlled stage (4) that is configured to keep said support structure (2) at a pre-defined temperature when the support structure (2) is arranged on the temperature-controlled stage (4), a first adapter (3) configured to hold said support structure (2), a transfer mechanism (60) that is configured to be connected to the first adapter (3) holding the support structure (2) and to move said support structure (2) into a container (8) containing a liquid cryogen (80) so that the sample on the support structure (2) contacts the cryogen (80). Furthermore, the invention relates to a corresponding method.

Abstract: A test unit for testing a plurality of communications devices is provided. The test unit comprises a test case database, which stores a first test case (including a first test case idle time) and a second test case. The second test case is shorter than the first test case idle time. The test unit comprises a signaling unit. The test unit comprises a test case execution manager, which reads from the test case database the first and second test case and controls the signaling unit to perform measurements according to the first test case on the first device under test until a beginning of the first test case idle time, and controls the signaling unit to perform measurements according to the second test case on the second device under test during the first test case idle time.

Abstract: The invention relates to a kitchen appliance, in particular a mixer, comprising a housing (2), on which a vessel (3) can be arranged, wherein the housing (2) has a vessel receiving area (4), to which the vessel (3) can be connected, wherein the vessel (3) and the vessel receiving area (4) have electric contacts (5, 6, 7, 8) for connecting an electric device of the vessel (3), in particular a heating device and/or a measuring device, to a power supply of the kitchen appliance.

Abstract: The present invention relates to a Statistical method of assessing whether a subject suffers from Cancer or is prone to suffering from Cancer, said method comprising the step of performing at least one Statistical algorithm for Classification and for regression on measurement data of the subject, wherein the measurement data of the subject comprises at least one of the following: a value of GATA6 Em isoform in at least one sample taken from the subject, a value NKX2-1 Em isoform in said at least one sample, a value of GATA6 Ad isoform in said at least one sample, NKX2-1 Ad isoform in said at least one sample; and wherein at least one of the following is used as at least one classifier or a component of at least one classifier in the Statistical method: GATA6 Em isoform, NKX2-1 Em isoform, GATA6 Ad isoform, NKX2-1 Ad isoform, ratio of GATA6 Em isoform/GATA6 Ad isoform, ratio of NKX2-1 Em isoform/NKX2-1 Ad isoform.

Abstract: Glazings comprising first and second channel-section glazing elements are described. The first and second channel-section glazing elements are arranged to define a cavity in which is located an inner glazing element comprising a glass glazing element, in particular a soda-lime-silica glass sheet, channel-section glazing element or sheet of rolled glass having at least one fire polished edge. The inner glazing element divides the cavity into at least two spaces to improve the thermal and/or noise performance of the glazing. By using low emissivity coatings on one or more major surfaces of one or more of the glazing elements, the thermal performance may be further improved. Mechanical performance may be modified by the particular type of inner glazing element used. It is possible to retrofit existing glazings to improve the thermal and/or noise performance thereof.

Abstract: A kitchen appliance, comprising a vessel and a cover for closing an opening in the vessel, wherein a locking mechanism, with which the cover can be locked to the vessel, and a control device, with which the locking state of the locking mechanism can be controlled, are provided. A proximity sensor is provided, it being possible to use the proximity sensor to detect the physical approach by a hand of a user below a predetermined distance from the proximity sensor, and the proximity sensor is connected to the control-device in such a way that an approach by the hand of the user to the proximity sensor below the predetermined distance can be detected by the control device and the locking mechanism can then be driven by the control device in such a way that the locking mechanism unlocks the cover. Therefore, a kitchen appliance of this kind comprising a vessel and a cover for closing an opening in the vessel is specified, with simple unlocking of the cover being made possible for the kitchen appliance.

Abstract: A process and also to a system for cleaning and maintaining a medical hand-held instrument, in particular a dental hand-held instrument, with an elongate grip sleeve in which elements are arranged which pertain to a drive arrangement and which are, in particular, rotatably supported, for example a shaft. For the purpose of cleaning and maintaining the hand-held instrument different media are conducted through it. In this connection a first medium, for example oil, is conducted merely through a power-transmission region surrounding the elements of the drive arrangement, whereas, on the other hand, a second medium, for example a cleaning agent, is conducted additionally also through at least one further cavity within the hand-held instrument.

Abstract: The invention concerns a dosing system for adjusting a dose volume of a fluid medium. The dosing system has a longitudinal center axis, a dosing sleeve with at least one communication opening, a dosing plunger, which can move axially in the dosing sleeve between a retracted and a depressed position to take up and dispense the medium through the communication opening, and a retraction limiting element to delimit a maximum axial retraction path of the dosing plunger. The retraction limiting element in at least one position can be axially fixed to the dosing plunger and can move radially to the longitudinal center axis between an inner position, axially fixed on the dosing plunger, and an outer position relative to the dosing plunger. In the inner position, it is completely inside the dosing sleeve. Furthermore, the dosing system has an end stop arranged on the dosing sleeve for interaction with the retraction limiting element in the retracted position of the dosing plunger.

Abstract: The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.

Abstract: Glazings comprising first and second channel-section glazing elements are described. The first and second channel-section glazing elements are arranged to define a cavity in which is located an inner glazing element comprising a glass glazing element, in particular a soda-lime-silica glass sheet, channel-section glazing element or sheet of rolled glass having at least one fire polished edge. The inner glazing element divides the cavity into at least two spaces to improve the thermal and/or noise performance of the glazing. By using low emissivity coatings on one or more major surfaces of one or more of the glazing elements, the thermal performance may be further improved. Mechanical performance may be modified by the particular type of inner glazing element used. It is possible to retrofit existing glazings to improve the thermal and/or noise performance thereof.

Abstract: The invention relates to a kitchen appliance, in particular a mixer, comprising a housing (2), on which a vessel (3) can be arranged, wherein the housing (2) has a vessel receiving area (4), to which the vessel (3) can be connected, wherein the vessel (3) and the vessel receiving area (4) have electric contacts (5, 6, 7, 8) for connecting an electric device of the vessel (3), in particular a heating device and/or a measuring device, to a power supply of the kitchen appliance.

Abstract: Malus domestica Borkh ‘Gala Schnico Red’ variety is distinguished by a unique combination of characteristics including an intensive red overcolor covering 100% of the fruit skin and a 30% higher number of lenticels per unit area on the fruit skin.