Abstract: The present invention relates to an inhibitor of the oncostatin M receptor ? or an inhibitor of an activator of the oncostatin M receptor ? for use in the treatment and/or prevention of heart failure. The present invention also relates to a method of treating and/or preventing heart failure comprising administering a pharmaceutically effective amount of an inhibitor of the oncostatin M receptor ? or an inhibitor of an activator of the oncostatin M receptor ? to a subject in need thereof. Further, the present invention also relates to methods of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of heart failure.

Abstract: The present invention relates to a variety of an apple tree obtained by branch mutation and by selection of the variety ‘Golden Clone B’. The present invention variety ‘Golden Parsi’ exhibits an appropriate distinguishability, homogeneity, uniformity, and stability. The vigor of the tree is medium. The tree type is ramified. The habit of the apple tree is spreading. The pubescence on an upper half of a shoot is weak or similar to the pubescence in ‘Golden Delicious’. The thickness as measured by the diameter at the center is medium or similar to the thickness in ‘Jonagold’ for a one year old shoot. The number of lenticels is many for a one year old shoot. The predominant color of a flower is dark pink in a balloon stage. An overcolor appears early in season with a brown-red color. The overcolor disappears almost totally, and toward harvest increases and gets red. The overcolor remains red even after months of storage.

Abstract: An item of seating furniture contains a seat providing a seat surface, a generally circular foot panel positioning the item of seating furniture on a floor, and a central part, which connects the seat to the foot panel and of which a vertical center axis runs centrally through the foot panel. The foot panel is of at least partially convex configuration and that side of the foot panel which is directed toward the floor is configured, at least in part, as a non-slip surface. This creates an ergonomic item of seating furniture which stands in a stable state.

Abstract: The invention relates to a coil for producing a magnetic field having at least one winding (12), which is manufactured from a superconductor, is cast into a plastic and whose winding end (19) which is arranged at the circumference (13) of the winding (12) is used for making contact with an electrical conductor (15). In order to provide coils with windings (12) consisting of superconductors which make robust contact-making possible given simple production, an electrically conductive connection piece (30) with a base region (31), which is connected to the winding end (19), and a top region (32) for connecting the conductor (15) is provided for contact-making purposes, the base region (31) of said connection piece (30) being covered partially in the radial direction by a reinforcing insert (14), which is cast into the plastic (20) and at least partially surrounds the winding (12).

Abstract: The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determinniation of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.

Abstract: The present invention relates to a pharmaceutical composition comprising (i) a nucleic acid molecule encoding a protein having Sirt7 function wherein said nucleic acid molecule (a) has the sequence of SEQ ID NO: 1, 3, 5 or 7; (b) encodes a protein having the sequence of SEQ ID NO: 2, 4, 6 or 8; (c) hybridizes under stringent conditions to the molecule of (a) or (b); or (d) has an identity on the nucleic acid level of at least 80% with the molecule of (a), (b) or (c); (ii) a vector comprising the nucleic acid molecule of (i); (iii) a host cell comprising the vector of (ii); or (iv) a protein encoded by the nucleic acid molecule of (i). The pharmaceutical composition is used for example in the treatment of age-related diseases. Furthermore, the invention relates to screening methods for the identification of compounds useful in the treatment of age-related diseases.

Abstract: A device for a method for determining the transmission performance of sub-channels of a transmission channel in a radio-communication system is specified, where data-comprising signal carriers are generated for the setup of the transmission channel within the radio-communication system and accommodated in the sub-channels of the transmission channel, and the transmission performance of the sub-channels is determined on the basis of the signal sub-carriers superposed with interferers. In this context, each sub-channel occupies a separate bandwidth sub-range of a total bandwidth range of the transmission channel. The bandwidth sub-range is disposed within the bandwidth at a spacing distance from other bandwidth sub-ranges of the total bandwidth range, and the interferers are limited to the bandwidth sub-range allocated to the respective sub-channel.

Abstract: An induction heater for heating metallic billets with a yoke of E-shaped cross-section, on the middle limb of which a superconducting coil is seated, has a well located between the middle limb and each one of the respective two outer limbs. A billet can be heated by being rotated in each one of the two wells.

Abstract: The invention relates to a coil for producing a magnetic field having at least one winding (12), which is manufactured from a superconductor, is cast into a plastic and whose winding end (19) which is arranged at the circumference (13) of the winding (12) is used for making contact with an electrical conductor (15). In order to provide coils with windings (12) consisting of superconductors which make robust contact-making possible given simple production, an electrically conductive connection piece (30) with a base region (31), which is connected to the winding end (19), and a top region (32) for connecting the conductor (15) is provided for contact-making purposes, the base region (31) of said connection piece (30) being covered partially in the radial direction by a reinforcing insert (14), which is cast into the plastic (20) and at least partially surrounds the winding (12).

Abstract: A power supply line for connecting a superconducting consumer system to a current delivery point, which is at a higher temperature than the consumer system, includes a carrier and a plurality of band-shaped, mechanically and electrically parallel high-temperature superconductors (HTSL). To achieve a high critical current density with simultaneously low heat-conducting capacity of the power supply line, the carrier includes at least one elongated plate that includes a sparingly (low) heat-conducting material, with a ratio of width to thickness of at least 3:1 and band-shaped HTSL that are arranged parallel adjacent to one another on the carrier. Each band-shaped HTSL also has a normally conducting current path.

Abstract: The invention relates to a method and to a test device (12) which is used to determine an error rate during the transfer of data (1) in a mobile radio system. Said mobile radio system comprises at least one transfer channel, wherein several data partial flows (2.1, 2.2, 2.6) are transferred. The several data partial flows (2.1, 2.2 . . . 2.6) are produced in a signal generator unit (8). A transport format is determined, in an individual manner, for each data partial flow (2.1, 2.2 . . . 2.6). The data partial flows (2.1, 2.2 . . . 2.6) are sent, respectively, to a number of transfer blocks which belong together (5.1, . . . 7.1). A device which is to be tested captures the transfer blocks (5.1, . . . 7.1) of the data partial flows (2.1, 2.2 . . . 2.6) and evaluates them. According to the accuracy of the evaluation, a positive or negative actuation signal (ACK, NACK) is sent back by the device which is to be tested. An error rate of each data partial flow (2.1, 2.2 . . . 2.

Abstract: A power supply line for connecting a superconducting consumer system to a current delivery point, which is at a higher temperature than the consumer system, includes a carrier and a plurality of band-shaped, mechanically and electrically parallel high-temperature superconductors (HTSL). To achieve a high critical current density with simultaneously low heat-conducting capacity of the power supply line, the carrier includes at least one elongated plate that includes a sparingly (low) heat-conducting material, with a ratio of width to thickness of at least 3:1 and band-shaped HTSL that are arranged parallel adjacent to one another on the carrier. Each band-shaped HTSL also has a normally conducting current path.

Abstract: In a method and apparatus for staking a hardened shaft in bores in a hydraulic lifter body, the shaft is inserted into the bores such that the shaft ends are substantially flush with the bore exits which are slightly chamfered to receive staked material displaced from the shaft. Mechanical rams that also define a first electrode are advanced axially of the shaft into contact with the shaft ends. A second electrode is brought into contact with the lifter body. Electric current is passed between the electrodes, causing resistive heating of the body and the shaft ends. The time and applied amperage are sufficient to cause softening of the shaft ends, at which time the current is switched off, and the first electrode is then driven against the shaft ends, causing the ends to be radially expanded into the chamfers. The remainder of the shaft is not softened nor retempered.

Abstract: A method and device for detecting an error rate of a receiver of data transmitted to a device that is to be checked is provided. A test device generates a data block having a first length and a test signal generated based on the data block is sent. The device to be checked receives and evaluates the test signal. Another data block having a different length is generated based on the evaluated test signal to obtain another data rate. The other data block is sent as a response signal in a different transmission direction, and is received and evaluated by the transmitter/receiver device of the test device. An evaluation unit compares the contents of both data blocks to detect the error rate, wherein the content of the shorter data block is compared with the content of a corresponding segment of the longer data block to determine the error rate.

Abstract: The present invention relates to a variety of an apple tree obtained by branch mutation and by selection of the variety Fuji. The present invention variety exhibits an appropriate distinguishability, homogeneity, uniformity, and stability. The vigor of the tree is strong. The tree type is ramified. The habit of the apple tree is drooping. The pubescence on an upper half of a shoot is weak. The thickness as measured by the diameter at the center is medium for a dormant one year old shoot. The number of lenticells is many for one year old dormant shoot. The color of an unopened flower is light pink in a balloon stage. The surface of the fruit is colored dark ruby red with a large number of small yellowish dots. Frequently the dots are disposed on curved lines with each line counting from about 4 to 8 dots.

Abstract: An elongate medical handpiece having a base part and a grip element at least partially surrounding this base part. In order to improve the construction of the handpiece, the grip element is of at least two grip parts, of which one is releasably connected with the other and/or with the base part and the grip parts are so configured that they lie on one another in a form-fitting manner.

Abstract: A sliding door for a motor vehicle, the sliding door being movable by a sliding motion into an opened and into a closed position, and having a fixing arrangement (2). The fixing arrangement (2) has an engagement module (3) and an engagement element (4), the engagement module (3) engaging the engagement element (4) when the sliding door is moved into the opened position and in this way fixing the sliding door in the opened position. It is proposed that the engagement module (3), when the sliding door has been fixed in the opened position, can be actuated by a drive in a motorized manner so that, in this way, the engagement element (4) is released and the sliding door can then be moved in the closing direction.

Abstract: A container insert having at least two primary pieces, wherein one of the pieces includes keying features that may be replaceable with other pieces having different keying features. A related single piece container insert includes multiple keying features formed on the interior and exterior surfaces of the container insert. A related coupling assembly includes a venting system that vents a fluid into the container after a valve in the coupling assembly, which is positioned in the container contents flow path, has been opened.

Abstract: A cutting insert is formed with a central planar support face, at least three cutting edges spaced outwardly from and around the support face and forming corners, and a land extending along each cutting edge between the respective corners and projecting from the respective cutting edge inward toward the support face. The land has a central region of a relatively great width measured perpendicular to the respective cutting edge and a pair of side regions flanking the central region and each of a relatively narrow width. The great width is equal to between 1.5 and 4 times the narrow width, and the land forms with a plane of the support face an outwardly open negative land angle of at least 0°.

Abstract: The present invention relates to a variety of an apple tree obtained by branch mutation and by selection of the variety Fuji. The present invention variety exhibits an appropriate distinguishability, homogeneity, uniformity, and stability. The vigor of the tree is strong. The tree type is ramified. The habit of the apple tree is drooping. The pubescence on an upper half of a shoot is weak or similar to the pubescence in Golden Delicious. The thickness as measured by the diameter at the center is medium or similar to the thickness in Jonagold for a dormant one year old shoot. The number of lenticels is many for one year old dormant shoot. The color of an unopened flower is light pink in a balloon stage. The surface of the fruit is colored dark ruby red with a large number of small yellowish dots. Frequently the dots are disposed on curved lines with each line counting from about 4 to 8 dots.