Abstract: The invention relates to combinations of peptides derived from a portion of an amino sequence of a grass pollen allergen, e.g. the allergens Phl p 1, Phl p 2, Phl p 3, Phl p 4 and/or Phl p 5, or a peptide variant thereof. Such peptides comprise at least one T cell epitope mid a high number of patients in a worldwide population will have HLA Class II alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by grass pollen species.

Abstract: A semiconductor device includes a first epitaxial layer, a second epitaxial layer disposed below the first epitaxial layer, a conductive layer disposed below and directly contacting the second epitaxial layer, and a plurality of spacers disposed between the second epitaxial layer and the conductive layer. The conductive layer includes a metal. The plurality of spacers include a bulk semiconductor material.

Abstract: Compositions and methods for effective delivery of oligonucleotide therapeutics, and in particular locked nucleic acid (AON)-containing gapmers, into the gastrointestinal (GI) tract are provided.

Abstract: Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.

Abstract: A technique allows for an electrical connection between a thermal abrasion heating catheter and the energy delivery console that utilizes serial communication. Accordingly, the serial communication allows data such as measured temperature, start/stop status, intended treatment area, device identification, device calibration parameters and/or use history to be conveyed along the same wires that deliver power to a heating element. For example, data can be conveyed along a two wire connection and provided at a frequency that is filtered out so that it is not delivered to a heating feature. In this example, one wire provides power to the heating element, one wire provided communication from the energy delivery console, and a third wire provides a common ground which the heating catheter uses to communicate with the energy delivery console.

Abstract: A thermal monitoring system (101) for sensing a temperature of a monitored device (104) includes a carrier (102) having a first surface (112) and a biasing element (122) coupled to the carrier (102) and configured to extend between the carrier (102) and the monitored device (104) to provide a first thermal conduction path therebetween. The biasing element (122) includes a first end (128) contacting the first surface (112) and a second end (130) opposite the first end (128) and configured to contact the monitored device (104). The biasing element (122) further includes a main body (132) formed of a thermally conductive material extending continuously between the first end (128) and the second end (130). The main body (132) is compressible between the monitored device (104) and the carrier (102). The thermal monitoring system (101) further includes a temperature sensor (124) coupled to the carrier (102) and configured to detect a temperature of the monitored device (104).

Abstract: A continuous-flow dryer for drying a material by means of hot air is provided with a fresh air supply device for supplying fresh air as supply air, an exhaust air recirculation device for removing exhaust air and for recirculating exhaust air as supply air, and a heat exchanger, through which fresh air on the one hand and exhaust air on the other hand are led, for transferring waste heat of the exhaust air into the fresh air. According to the invention, the removed exhaust air is supplied at the bottom into the heat exchanger.

Abstract: A continuous-flow dryer for drying a material by hot air is provided with a first and a second section, through which the material flows successively in a transport direction. It includes a fresh air supply device, an exhaust air recirculation device for removing exhaust air and for recirculating exhaust air as supply air, and a heat exchanger, through which fresh air and exhaust air are led, for transferring waste heat of the exhaust air into the fresh air. With the exhaust air recirculation device a first part of the exhaust air is removed from the first section and recirculated directly into the first section. Furthermore, a second part of the exhaust air is removed from the first section, led through the heat exchanger, and recirculated as supply air into the first section. The fresh air supply device supplies fresh air as supply air into the second section.

Abstract: The invention relates to a connector head (12) comprising an interior space (40), a tank connector (13) which is in fluid communication with the interior space (40) and which can be fluidly connected to a valve apparatus (10) mounted on the tank (9) for filling or emptying the tank (9), a product port (14) in fluid communication with the interior space (40) and a discharge port (33) in fluid communication with the interior space (40). To allow a tank to be filled and emptied under improved hygienic conditions, it is proposed that the connector head (12) comprises a first valve (29), with which first valve (29) the product port (14) can be shut off from the interior space (40), a second valve (34), with which second valve (34) the discharge port (33) can be shut off from the interior space (40), and a cleaning device (38) adapted and arranged to clean the interior space (40) and the tank connector (13). The invention also relates to a valve block.

Abstract: A continuous-flow dryer for drying a material by hot air is provided with a first and a second section, through which the material is passed successively in a transport direction. It includes a fresh air supply device, an exhaust air recirculation device for removing exhaust air and recirculating it as supply air, and a heat exchanger, through which fresh air and exhaust air are led, for transferring waste heat of the exhaust air into the fresh air. With the exhaust air recirculation device a first part of the exhaust air is removed from the first section and recirculated as supply air directly into the first section. Furthermore, a second part of the exhaust air is removed from the first section, led through the heat exchanger, and recirculated as supply air into the first section. The fresh air supply device supplies fresh air as supply air into the second section.

Abstract: A method for performing computing procedures with a control unit of a transportation vehicle wherein the control unit is not installed in a fixed position in the transportation vehicle, but is instead a removable design. The control unit performs control tasks for transportation vehicle functions in the transportation vehicle and is used outside the transportation vehicle for vehicle-independent calculations. The control unit in the transportation vehicle uses a computing power and/or memory capacity which is/are not required for the control tasks for vehicle-independent calculations in the transportation vehicle, wherein these vehicle-independent calculations are continued outside the transportation vehicle when the control unit is removed from the transportation vehicle.

Abstract: A semiconductor device includes a first epitaxial layer, a second epitaxial layer disposed below the first epitaxial layer, a conductive layer disposed below and directly contacting the second epitaxial layer, and a plurality of spacers disposed between the second epitaxial layer and the conductive layer. The conductive layer includes a metal. The plurality of spacers include a bulk semiconductor material.

Abstract: A semiconductor device includes a trench extending through a semiconductor substrate and an epitaxial layer disposed over a first side of the semiconductor substrate. The epitaxial layer partially fills a portion of the trench. The semiconductor device further includes a back side metal layer disposed over a second side of the semiconductor substrate. The back side metal layer extends into the trench and fills the remaining portion of the trench. The epitaxial layer partially filling the trench contacts the back side metal layer filling the remaining portion within the trench.