Patents by Inventor Thomas Daniel Heightman

Thomas Daniel Heightman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nrf2 REGULATORS
    Publication number: 20190224212
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: April 4, 2019
    Publication date: July 25, 2019
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • Arylcyclohexyl pyrazoles as NRF2 regulators
    Patent number: 10351530
    Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 16, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics Limited
    Inventors: James Callahan, Jeffrey K. Kerns, Tindy Li, Brent W. McCleland, Hong Nie, Joseph E. Pero, Thomas Glanmor Davies, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, David Norton, Marinus Leendert Verdonk, Alison Jo-Anne Woolford
  • NRF2 regulators
    Patent number: 10272095
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 30, 2019
    Assignees: GlaxoSmithKline Intellectual Propert Development Limited, Astex Therapeutics, Limited
    Inventors: Jeffrey K. Kerns, James Francis Callahan, Hongxing Yan, Thomas Daniel Heightman, Jeffrey Charles Boehm, Alison Jo-Anne Woolford
  • BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Publication number: 20190047990
    Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 14, 2019
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Valerio BERDINI, Ildiko Maria BUCK, James Edward Harvey DAY, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, Christopher William MURRAY, David NORTON, Marc O'REILLY, Alison Jo-Anne WOOLFORD, Michael Liam COOKE, David COUSIN, Stuart Thomas ONIONS, Jonathan Martin SHANNON, John Paul WATTS
  • NRF2 Regulators
    Publication number: 20190002454
    Abstract: The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Inventors: Jeffrey Charles BOEHM, Thomas Glanmor DAVIES, Alison Jo-Anne WOOLFORD, Charlotte Mary GRIFFITHS-JONES, Hendrika Maria Gerarda WILLEMS, David NORTON, Gordon SAXTY, Thomas Daniel HEIGHTMAN, Tindy LI, Jeffrey K. KERNS, Roderick S. DAVIS, Hongxing YAN
  • Nrf2 regulators
    Patent number: 10144731
    Abstract: The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: December 4, 2018
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics, Ltd
    Inventors: Thomas Glanmor Davies, Alison Jo-anne Woolford, Hendrika Maria Gerarda Willems, David Norton, Thomas Daniel Heightman, Jeffrey K. Kerns
  • ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS
    Publication number: 20180282283
    Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 4, 2018
    Inventors: James CALLAHAN, Jeffrey K. KERNS, Tindy LI, Brent W. McCLELAND, Hong NIE, Joseph E. PERO, Thomas Glanmor DAVIES, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, David NORTON, Marinus Leendert VERDONK, Alison Jo-Anne WOOLFORD
  • BIARYL PYRAZOLES AS NRF2 REGULATORS
    Publication number: 20180282349
    Abstract: The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 4, 2018
    Inventors: James CALLAHAN, Jeffrey K. KERNS, Peng LI, Tindy LI, Brent W. McCLELAND, Hong NIE, Joseph E. PERO, Thomas Glanmor DAVIES, Maria GRAZIA CARR, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, David NORTON, Marinus Leedert VERDONK, Alison Jo-Anne WOOLFORD, Hendrika Maria Gerarda WILLEMS
  • Nrf2 REGULATORS
    Publication number: 20180179187
    Abstract: Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 28, 2018
    Inventors: Jeffrey K. KERNS, James CALLAHAN, Hongxing YAN, Thomas Daniel HEIGHTMAN, Charlotte Mary GRIFFITHS-JONES, Alison Jo-Anne WOOLFORD, Tindy LI, Ami Lakdawala SHAH, Roderick S. DAVIS, David NORTON, Jeffrey Charles BOEHM, Paris L. HAMILTON
  • Nrf2 REGULATORS
    Publication number: 20180179167
    Abstract: The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 28, 2018
    Inventors: Jeffrey K. KERNS, Tindy LI, Hongxing YAN, Thomas Daniel HEIGHTMAN, Alison Jo-Anne WOOLFORD, Charlotte Mary GRIFFITHS-JONES, Hendrika Maria Gerarda WILLEMS
  • Nrf2 REGULATORS
    Publication number: 20180169110
    Abstract: The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 21, 2018
    Inventors: Jeffrey K. KERNS, Jamas Francis CALLAHAN, Hongxing YAN, Thomas Daniel HEIGHTMAN, Jeffrey Charles BOEHM, Alison Jo-Anne WOOLFORD
  • Bicyclic heterocycle compounds and their uses in therapy
    Patent number: 9980973
    Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: May 29, 2018
    Assignee: ASTEX THERAPEUTICS LIMITED
    Inventors: Gianni Chessari, Christopher Norbert Johnson, Lee William Page, Thomas Daniel Heightman, Alessia Millemaggi, Steven Howard, Gordon Saxty
  • BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
    Publication number: 20170334907
    Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: May 3, 2017
    Publication date: November 23, 2017
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Alison Jo-Anne WOOLFORD, Steven HOWARD, Ildiko Maria BUCK, Gianni CHESSARI, Christopher Norbert JOHNSON, Emiliano TAMANINI, James Edward Harvey DAY, Elisabetta CHIARPARIN, Thomas Daniel HEIGHTMAN, Martyn FREDERICKSON, Charlotte Mary GRIFFITHS-JONES
  • BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
    Publication number: 20170224705
    Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: January 20, 2017
    Publication date: August 10, 2017
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Gianni CHESSARI, Christopher Norbert JOHNSON, Lee William PAGE, Thomas Daniel Heightman, Alessia Millemaggi, Steven HOWARD, Gordon SAXTY
  • Bicyclic heterocycle compounds and their uses in therapy
    Patent number: 9676768
    Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 13, 2017
    Assignee: ASTEX THERAPEUTICS LIMITED
    Inventors: Alison Jo-Anne Woolford, Steven Howard, Ildiko Maria Buck, Gianni Chessari, Christopher Norbert Johnson, Emiliano Tamanini, James Edward Harvey Day, Elisabetta Chiarparin, Thomas Daniel Heightman, Martyn Frederickson, Charlotte Mary Griffiths-Jones
  • Bicyclic heterocycle compounds and their uses in therapy
    Patent number: 9663512
    Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: May 30, 2017
    Assignee: ASTEX THERAPEUTICS LIMITED
    Inventors: Gianni Chessari, Christopher Norbert Johnson, Lee William Page, Alessia Millemaggi, Steven Howard, Gordon Saxty, Thomas Daniel Heightman
  • NRF2 REGULATORS
    Publication number: 20160318917
    Abstract: The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Inventors: Jeffrey Charles Boehm, Thomas Glanmor Davies, Alison Jo-anne Woolford, Charlotte Mary Griffiths-Jones, Hendrika Maria Gerarda Willems, David Norton, Gordon Saxity, Thomas Daniel Heightman, Tindy Li, Jeffrey K. Kerns, Roderick S. Davis, Hongxing Yan
  • BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
    Publication number: 20150291586
    Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: March 20, 2015
    Publication date: October 15, 2015
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Alison Jo-Anne WOOLFORD, Steven HOWARD, Ildiko Maria BUCK, Gianni CHESSARI, Christopher Norbert JOHNSON, Emiliano TAMANINI, James Edward Harvey DAY, Elisabetta CHIARPARIN, Thomas Daniel HEIGHTMAN, Martyn FREDERICKSON, Charlotte Mary GRIFFITHS-JONES
  • BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
    Publication number: 20150266873
    Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 24, 2015
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Gianni Chessari, Christopher Norbert Johnson, Lee William Page, Alessia Millemaggi, Steven Howard, Gordon Saxty, Thomas Daniel Heightman
  • Bicyclic heterocycle compounds and their uses in therapy
    Patent number: 9018214
    Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: April 28, 2015
    Assignee: Astex Therapeutics Limited
    Inventors: Alison Jo-Anne Woolford, Steven Howard, Ildiko Maria Buck, Gianni Chessari, Christopher Norbert Johnson, Emiliano Tamanini, James Edward Harvey Day, Elisabetta Chiarparin, Thomas Daniel Heightman, Martyn Frederickson, Charlotte Mary Griffiths-Jones