Patents by Inventor Thomas Daniel Heightman

Thomas Daniel Heightman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY
    Publication number: 20140179666
    Abstract: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: April 20, 2012
    Publication date: June 26, 2014
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Alison Jo-Anne Woolford, Steven Howard, Ildiko Maria Buck, Gianni Chessari, Christopher Norbert Johnson, Emiliano Tamanini, James Edward Harvey Day, Elisabetta Chiarparin, Thomas Daniel Heightman, Martyn Frederickson, Charlotte Mary Griffiths-Jones
  • Compounds
    Patent number: 8329730
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: December 11, 2012
    Assignee: Glaxo Group Limited
    Inventors: Thomas Daniel Heightman, John Skidmore, Hailong Wang, Colin David Eldred, Jag Paul Heer
  • Oxadiazole derivatives active on sphingosine-1-phosphate (S1P)
    Patent number: 8278324
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: October 2, 2012
    Assignee: Glaxo Group Limited
    Inventors: Jag Paul Heer, Thomas Daniel Heightman
  • Oxadiazole derivatives active on sphingosine-1-phosphate (SIP)
    Patent number: 8263620
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 11, 2012
    Assignee: Glaxo Group Limited
    Inventors: Jag Paul Heer, Thomas Daniel Heightman
  • Oxadiazole derivatives active on sphingosine-1-phosphate (S1P)
    Patent number: 8222245
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: July 17, 2012
    Assignee: Glaxo Group Limited
    Inventors: Emmanuel Hubert Demont, Jag Paul Heer, John Skidmore, Ian David Wall, Jason Witherington, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson
  • COMPOUNDS
    Publication number: 20110039889
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: April 29, 2009
    Publication date: February 17, 2011
    Inventors: Colin David Eldred, Jag Paul Heer, Thomas Daniel Heightman, John Skidmore, Hailong Wang
  • OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP)
    Publication number: 20100298373
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: November 25, 2010
    Inventors: Jag Paul Heer, Thomas Daniel Heightman
  • OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP)
    Publication number: 20100273771
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 28, 2010
    Inventors: Emmanuel Hubert Demont, Jag Paul Heer, John Skidmore, Ian David Wall, Jason Witherington, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson
  • 1, 2, 4 -OXADIAZOLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20100273770
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 28, 2010
    Inventors: Jag Paul Heer, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson, John Skidmore, Ian David Wall
  • N-[(3,5-DICHLOROPHENYL)METHYL]-2-(4-METHYL-1-PIPERAZINYL)-2-(1-NAPHTHALENYL)ETHANAMIDE AS GHRELIN RECEPTOR MODULATOR
    Publication number: 20100267734
    Abstract: The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes for their preparation, intermediates useable in these processes, pharmaceutical compositions containing them and their use in therapy, for example as modulators of the growth hormone secretagogue receptor (also referred to as the ghrelin receptor or GHSR1a receptor) and/or for the treatment and/or prophylaxis of a disorder mediated by the ghrelin receptor.
    Type: Application
    Filed: June 5, 2008
    Publication date: October 21, 2010
    Applicant: Glaxo Group Limited
    Inventor: Thomas Daniel Heightman
  • OXADIAZOLE DERIVATIVES FOR USE AS S1P1 AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
    Publication number: 20100261767
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 14, 2010
    Inventors: Jag Paul Heer, Thomas Daniel Heightman, John Skidmore
  • COMPOUNDS
    Publication number: 20100174065
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: January 28, 2009
    Publication date: July 8, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Jag Paul HEER, Thomas Daniel HEIGHTMAN, David Nigel HURST, Christopher Norbert JOHNSON, John SKIDMORE, Ian David WALL
  • OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P)
    Publication number: 20100152235
    Abstract: The present invention relates to a novel oxadiazole derivative having pharmacological activity, processes for its preparation, pharmaceutical compositions containing it and its use in the treatment of various disorders.
    Type: Application
    Filed: February 24, 2010
    Publication date: June 17, 2010
    Inventors: Jag Paul Heer, Thomas Daniel Heightman
  • SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS
    Publication number: 20100075953
    Abstract: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
    Type: Application
    Filed: September 18, 2009
    Publication date: March 25, 2010
    Applicant: Glaxo Group Limited
    Inventors: Rachael Ancliff, Colin David Eldred, Ashley Paul Hancock, Thomas Daniel Heightman, Heather Hobbs, Simon Teanby Hodgson, David Matthew Wilson
  • Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists
    Patent number: 7615550
    Abstract: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: November 10, 2009
    Assignee: Glaxo Group Limited
    Inventors: Thomas Daniel Heightman, Simon Teanby Hodgson, Matthew J Lindon, David Matthew Wilson
  • Pyridinylimidazoles
    Publication number: 20040220230
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: 1
    Type: Application
    Filed: January 29, 2004
    Publication date: November 4, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Michael Stewart Hadley, John David Harling, Frank Peter Harrington, Jag Paul Heer, Thomas Daniel Heightman, Andrew Hele Payne
  • Pyridyl-substituted triazoles as tgf inhibitors
    Publication number: 20040152738
    Abstract: Pyridyl substituted triazoles of formula (I) 1
    Type: Application
    Filed: March 22, 2004
    Publication date: August 5, 2004
    Inventors: Laramie Mary Gaster, John David Harling, Jag Paul Heer, Thomas Daniel Heightman, Andrew Hele Payne
  • Pyridinylimidazoles
    Publication number: 20030166633
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2 and R3 represent various functional groups, and one of X1 and X2 is N and the other is NR10; and their use as pharmaceuticals.
    Type: Application
    Filed: October 29, 2002
    Publication date: September 4, 2003
    Inventors: Laramie Mary Gaster, Michael Stewart Hadley, John David Harling, Frank Peter Harrington, Jag Paul Heer, Thomas Daniel Heightman, Andrew Hele Payne