Patents by Inventor Thomas E. McDonagh

Thomas E. McDonagh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SirT INHIBITORS THAT BIND TO NAD
    Publication number: 20160113903
    Abstract: Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
    Type: Application
    Filed: June 4, 2015
    Publication date: April 28, 2016
    Applicant: ELIXIR PHARMACEUTICALS, INC.
    Inventors: Andrew D. Napper, Peter DiStefano, Rory Curtis, Jeffrey Hixon, Thomas E. McDonagh, L. Julie Huber, Jonathan M. Solomon, Russel J. Thomas, Jean-francois Pons
  • SirT INHIBITORS THAT BIND TO NAD
    Publication number: 20140163029
    Abstract: Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
    Type: Application
    Filed: May 24, 2013
    Publication date: June 12, 2014
    Applicant: ELIXIR PHARMACEUTICALS, INC.
    Inventors: Andrew D. Napper, Peter DiStefano, Rory Curtis, Jeffrey Hixon, Thomas E. McDonagh, L. Julie Huber, Jonathan M. Solomon, Russel J. Thomas, Jean-francois Pons
  • Therapeutic compounds and related methods of use
    Publication number: 20100168084
    Abstract: Methods of using compounds that are HAT inhibitors are described herein.
    Type: Application
    Filed: May 8, 2009
    Publication date: July 1, 2010
    Inventors: L. Julie Huber, Thomas E. McDonagh
  • Aggrecanase structure
    Patent number: 7615363
    Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: November 10, 2009
    Assignee: Wyeth
    Inventors: Lidia Mosyak, Thomas Saltmarsh Rush, III, Xiaotian Zhong, Thomas E. McDonagh, Katy E. Georgiadis, Phaik-Eng Sum, Edward R. LaVallie, Lisa A. Collins-Racie, Christopher John Corcoran, Ravindra Kumar, Tracy Hebert, Stephane Hubert Olland, Stewart Andrews Mackie
  • Crystalline IL-6 and models of the molecular structure of IL-6
    Publication number: 20030068300
    Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
    Type: Application
    Filed: September 19, 2002
    Publication date: April 10, 2003
    Applicant: Wyeth
    Inventors: William S. Somers, Mark L. Stahl, Jasbir S. Seehra, Guang-Yi Xu, Thomas E. McDonagh, Hsiang-Ai Yu, Jin Hong
  • Crystalline IL-6 and models of the molecular structure of IL-6
    Patent number: 6461604
    Abstract: Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antagonists of such interactions. Crystalline human IL-6 is also provided.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: October 8, 2002
    Assignee: Genetics Institute, LLC
    Inventors: William S. Somers, Mark L. Stahl, Jasbir S. Seehra, Guang-Yi Xu, Thomas E. McDonagh, Hsiang-Ai Yu, Jin Hong