Patents by Inventor Thomas E. Richardson

Thomas E. Richardson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF RESPIRATORY TRACT DISEASES AND INFECTIONS WITH ASCORBIC ACID COMPOSITIONS
    Publication number: 20230165929
    Abstract: The application is directed to a method of inhibiting or reducing growth of clinical isolate bacteria comprising contacting the clinical isolate with a composition comprising glutathione, a glutathione derivative, a glutathione conjugate, a pharmaceutically-acceptable salt thereof, or any combination thereof.
    Type: Application
    Filed: January 27, 2023
    Publication date: June 1, 2023
    Inventors: Dan COPELAND, Carolyn DURHAM, Thomas E. RICHARDSON
  • Treatment of respiratory tract diseases and infections with ascorbic acid compositions
    Patent number: 11602555
    Abstract: The application is directed to a method of inhibiting or reducing growth of clinical isolate bacteria comprising contacting the clinical isolate with a composition comprising glutathione, a glutathione derivative, a glutathione conjugate, a pharmaceutically-acceptable salt thereof, or any combination thereof.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: March 14, 2023
    Assignee: RENOVION, INC.
    Inventors: Dan Copeland, Carolyn Durham, Thomas E. Richardson
  • SOLID DOSAGE FORM OF N-1-PYRROLIDINE-N-5-(3-TRIFLUOROMETHOXY)PHENYL BIGUANIDE AND USES THEREOF
    Publication number: 20230000820
    Abstract: The invention features solid dosage forms of N-1-pyrrolidine-N-5-(3-trifluoromethoxy)phenyl biguanide, or a pharmaceutically acceptable salt thereof, where the solid dosage form includes an enteric coating and uses thereof.
    Type: Application
    Filed: June 27, 2022
    Publication date: January 5, 2023
    Inventors: Dean WELSCH, Thomas E. RICHARDSON
  • Calcium channel inhibitors
    Patent number: 11130750
    Abstract: The present disclosure describes carbamate analogs of mibefradil, as well as their compositions and methods of use. The compounds block the activity of one or more isoforms of voltage-gated calcium channels and are useful in the treatment of diseases including, e.g., cancer.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: September 28, 2021
    Assignee: CAVION, INC.
    Inventors: Thomas E. Richardson, Michelle Higgin, Timothy MacDonald
  • CALCIUM CHANNEL INHIBITORS
    Publication number: 20200385367
    Abstract: The present disclosure describes carbamate analogs of mibefradil, as well as their compositions and methods of use. The compounds block the activity of one or more isoforms of voltage-gated calcium channels and are useful in the treatment of diseases including, e.g., cancer.
    Type: Application
    Filed: February 15, 2018
    Publication date: December 10, 2020
    Inventors: Thomas E. Richardson, Michelle Higgin, Timothy MacDonald
  • TREATMENT OF RESPIRATORY TRACT DISEASES AND INFECTIONS WITH ASCORBIC ACID COMPOSITIONS
    Publication number: 20190351005
    Abstract: The application is directed to a method of inhibiting or reducing growth of clinical isolate bacteria comprising contacting the clinical isolate with a composition comprising glutathione, a glutathione derivative, a glutathione conjugate, a pharmaceutically-acceptable salt thereof, or any combination thereof.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 21, 2019
    Inventors: Dan COPELAND, Carolyn DURHAM, Thomas E. RICHARDSON
  • Benzamide derivatives as modulators of the follicle stimulating hormone
    Patent number: 10183935
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 22, 2019
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Matthew G. Jenks, Robert J. Foglesong
  • Imidazole compounds as modulators of FSHR and uses thereof
    Patent number: 10138233
    Abstract: The present invention relates to imidazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: November 27, 2018
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Marianne Donnelly, Ngan Nguyen, Xuliang Jiang
  • Benzamides
    Patent number: 9938262
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R6, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: April 10, 2018
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Andreas Goutopoulos, Thomas E. Richardson, Jiezhen Li, Brian H. Heasley, Pandi Bharathi
  • C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof
    Patent number: 9938268
    Abstract: Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: April 10, 2018
    Assignee: Merck Patent GmbH
    Inventors: Yufang Xiao, Bayard R. Huck, Amanda E. Sutton, Thomas E. Richardson, Srinivasa R. Karra
  • Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4
    Patent number: 9879004
    Abstract: The present invention relates to novel acetylene derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: January 30, 2018
    Assignee: Merck Patent GMBH
    Inventors: Thomas E. Richardson, Nadia Brugger, Justin Potnick
  • Dihydropyrazoles
    Publication number: 20170368030
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 28, 2017
    Inventors: Henry YU, Thomas E. RICHARDSON, Robert James FOGLESONG, Lizbeth Celeste DESELM, Andreas GOUTOPOULOS
  • Dihydropyrazoles
    Patent number: 9775830
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 3, 2017
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Robert James Foglesong, Lizbeth Celeste Deselm, Andreas Goutopoulos
  • Substituted quinoxalines as positive allosteric modulators of mGluR4
    Patent number: 9763938
    Abstract: The present invention relates to the use of novel quinoxaline derivatives of formula (I) as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: September 19, 2017
    Assignee: MERCK PATENT GMBH
    Inventor: Thomas E. Richardson
  • BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE
    Publication number: 20170226096
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: April 26, 2017
    Publication date: August 10, 2017
    Inventors: Henry YU, Thomas E. RICHARDSON, Pandi BHARATHI, Brian H. HEASLEY, Matthew G. JENKS, Robert J. FOGLESONG
  • Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4
    Patent number: 9708321
    Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: July 18, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Nadia Brugger, Brian L. Hodous, Amanda E. Sutton, Justin Potnick, Theresa L. Johnson, Thomas E. Richardson, Thomas Francis Nelson Haxell, James M. Dorsey, Robert James Foglesong
  • Dihydropyrazoles
    Publication number: 20170071910
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: November 3, 2016
    Publication date: March 16, 2017
    Inventors: Henry YU, Thomas E. RICHARDSON, Robert James FOGLESONG, Lizbeth Celeste DESELM, Andreas GOUTOPOULOS
  • BENZAMIDES
    Publication number: 20170022191
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R6, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: October 3, 2016
    Publication date: January 26, 2017
    Inventors: Henry YU, Andreas GOUTOPOULOS, Thomas E. RICHARDSON, Jiezhen LI, Brian H. HEASLEY, Pandi BHARATHI
  • Dihydropyrazoles
    Patent number: 9517227
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: December 13, 2016
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Robert James Foglesong, Lizbeth Celeste Deselm, Andreas Goutopoulos
  • Benzamides
    Patent number: 9498475
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R6, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: November 22, 2016
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Andreas Goutopoulos, Thomas E. Richardson, Jiezhen Li, Brian H. Heasley, Pandi Bharathi