Patents by Inventor Thomas E. Richardson

Thomas E. Richardson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4
    Publication number: 20160317533
    Abstract: The present invention relates to the use of novel quinoxaline derivatives of formula (I) as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Application
    Filed: July 14, 2016
    Publication date: November 3, 2016
    Applicant: MERCK PATENT GMBH
    Inventor: Thomas E. RICHARDSON
  • SYSTEM AND METHOD FOR PRICE ANALYSIS AND OPTIMIZATION
    Publication number: 20160253690
    Abstract: A system and method for providing insights into pricing strategy for a retail store, particularly for optimizing prices of fast moving, long life cycle items in the consumer package goods industries is disclosed. The system includes a computer having a display, a processor, and memory, an input device for allowing a user to interact with the computer processor and display to change one or more parameters of sales and gross margin percent (GM %) so as to determine a price for at least one item for sale and an output device for outputting new pricing information for the at least one item. The method includes steps of receiving sales and cost data for items, displaying one or more graphs of sales and GM % for a plurality of items, iteratively updating the graphs based on user selected optimization parameters and outputting new prices for the one or more items based on the optimization.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 1, 2016
    Inventor: Thomas E. Richardson
  • Benzamide derivatives as modulators of the follicle stimulating hormone
    Patent number: 9409897
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: August 9, 2016
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Matthew G. Jenks, Robert J. Foglesong
  • IMIDAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF
    Publication number: 20160152609
    Abstract: The present invention relates to imidazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
    Type: Application
    Filed: June 24, 2014
    Publication date: June 2, 2016
    Inventors: Henry YU, Thomas E. RICHARDSON, Marianne DONNELLY, Ngan NGUYEN, Xuliang JIANG
  • BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE
    Publication number: 20160137632
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: November 18, 2015
    Publication date: May 19, 2016
    Inventors: Henry YU, Thomas E. RICHARDSON, Pandi BHARATHI, Brian H. HEASLEY, Matthew G. JENKS, Robert J. FOGLESONG
  • BENZAMIDES
    Publication number: 20160022670
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R6, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: September 24, 2015
    Publication date: January 28, 2016
    Inventors: Henry YU, Andreas GOUTOPOULOS, Thomas E. RICHARDSON, Jiezhen LI, Brian H. HEASLEY, Pandi BHARATHI
  • Substituted Acetylene Derivatives and their Use as Positive Allosteric Modulators of mGluR4
    Publication number: 20150376182
    Abstract: The present invention relates to novel acetylene derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Application
    Filed: January 15, 2014
    Publication date: December 31, 2015
    Applicant: Merck Patent GMBH
    Inventors: Thomas E. RICHARDSON, Nadia BRUGGER, Justin POTNICK
  • SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4
    Publication number: 20150374687
    Abstract: The present invention relates to novel quinoxaline derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Application
    Filed: January 16, 2014
    Publication date: December 31, 2015
    Inventor: Thomas E. RICHARDSON
  • Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4
    Publication number: 20150361079
    Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 17, 2015
    Applicant: Merck Patent GMBH
    Inventors: Nadia BRUGGER, Brian L. HODOUS, Amanda E. SUTTON, Justin POTNICK, Theresa L. JOHNSON, Thomas E. RICHARDSON, Thomas Francis Nelson HAXELL, James M. DORSEY, Robert James FOGLESONG
  • Benzamides
    Patent number: 9181226
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R8, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: November 10, 2015
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Jiezhen Li, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Andreas Goutopoulos
  • Amino azaheterocyclic carboxamides
    Patent number: 9040560
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: May 26, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Thomas E. Richardson, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Andreas Goutopoulos, Ruoxi Lan, David Perrey, Harold George Vandeveer, Lesley Liu-Bujalski, Frank Stieber, Brian L. Hodous, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • Azaheterocyclic compounds
    Patent number: 9023847
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Nadia Brugger, Thomas E. Richardson, Harold George Vandeveer, Bayard R. Huck, Ruoxi Lan, Justin Potnick
  • BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE
    Publication number: 20150011562
    Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 8, 2015
    Inventors: Henry Yu, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Matthew G. Jenks, Robert J. Foglesong
  • Dihydropyrazoles
    Publication number: 20140296238
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: June 10, 2014
    Publication date: October 2, 2014
    Inventors: Henry YU, Thomas E. RICHARDSON, Robert James FOGLESONG, Lizbeth Celeste DESELM, Andreas GOUTOPOULOS
  • Dihydropyrazoles
    Patent number: 8791114
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: July 29, 2014
    Assignee: Merck Patent GmbH
    Inventors: Henry Yu, Thomas E. Richardson, Robert James Foglesong, Lizbeth Celeste DeSelm, Andreas Goutopoulos
  • Bicyclic azaheterocyclic carboxamides
    Patent number: 8710044
    Abstract: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 29, 2014
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Constantin Neagu, Reinaldo Jones, Lizbeth Celeste DeSelm, Yufang Xiao, Srinivasa R. Karra, Ruoxi Lan, Igor Mochalkin, Amanda E. Sutton, Thomas E. Richardson
  • Novel Amino Azaheterocyclic Carboxamides
    Publication number: 20140107156
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 17, 2014
    Applicant: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Thomas E. Richardson, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Andreas Goutopoulos, Ruoxi Lan, David Perrey, Harold George Vandeveer, Lesley Liu-Bujalski, Frank Steiber, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • Amino azaheterocyclic carboxamides
    Patent number: 8637532
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: January 28, 2014
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Ruoxi Lan, Thomas E. Richardson, David Perrey, Harold George Vandeveer, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Lesley Liu-Bujalski, Andreas Goutopoulos, Frank Stieber, Brian L. Hodous, Hui Qiu, Reinaldo Jones, Brian H. Heasley
  • Dihydropyrazoles
    Publication number: 20130172351
    Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
    Type: Application
    Filed: June 26, 2012
    Publication date: July 4, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Henry Yu, Thomas E. Richardson, Robert James Foglesong, Lizbeth Celeste DeSelm, Andreas Goutopoulos
  • Bicyclic Azaheterocyclic Carboxamides
    Publication number: 20130137677
    Abstract: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: July 1, 2011
    Publication date: May 30, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Bayard R. Huck, Constantin Neagu, Reinaldo Jones, Lizbeth Celeste DeSelm, Yufang Xiao, Srinivasa R. Karra, Ruoxi Lan, Igor Mochalkin, Amanda E. Sutton, Thomas E. Richardson