Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface asialoglycoprotein receptor (ASGPR). The cell surface ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell abound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: A method for producing polyether ester carbonate polyols by catalytically adding alkylene oxide and carbon dioxide to an H-functional initiator substance in the presence of a double metal cyanide catalyst. The method comprises the following steps: (?) feeding a partial amount of H-functional initiator substance and/or a suspension agent which does not have any H-functional groups into a reactor, optionally together with DMC catalyst, (?) adding alkylene oxide and optionally carbon dioxide to the reactor during the reaction. The method is characterized in that in step (?) lactide is added to the reactor.

Abstract: A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A1) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I1?2), preferred two isocyanate groups (I1=2), wherein the epoxide compound (B) comprises a epoxide compound (B1) and an epoxide compound (B2), wherein the epoxide compound (B2) is different from the epoxide compound (B1) wherein the epoxide compound (B1) comprising at least two terminal epoxide groups (F1?2), preferred two terminal epoxide groups (F1=2), linked together by a linking group (L1) and the epoxide compound (B2) comprising at least two terminal epoxide groups (F2?2)), preferred two terminal epoxide groups (F2=2), linked together by a linking group (L2), wherein the linking group (L2) comprises acyclic and covalent bonds to each other free of conjugated multiple bond

Abstract: Method for the production of polyoxazolidinone compounds, comprising the reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) having a pKb-value of ?9. The invention is also related to the resulting polyoxazolidinone compounds.

Abstract: A method for separating a double metal cyanide catalyst (DMC catalyst) from polyol, comprising: A) initially charging a polyol comprising DMC catalyst, an alcohol, and optionally a filtration aid into a reactor, the mixture being heated, B) filtering the mixture from step A), and C) optionally separating the alcohol from the filtrate of step B), wherein in step A), as the alcohol, 4% by weight to 12% by weight of ethanol, based on 100% by weight of polyol, without a chelating agent is used.

Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.

Abstract: Production of a transistor, the channel structure of which comprises at least one finned channel structure, the method comprising: forming, from a substrate (1), a molding block (3), forming, on the molding block, a thin layer (7) made from a given semiconductor or semi-metallic material, and consisting of one to ten atomic or molecular monolayers of two-dimensional crystal, withdrawing the molding block while retaining a portion (7a) of the thin layer extending against a lateral face of the molding block, said retained portion (7a) forming a fin that is capable of forming a channel structure of the transistor, producing a coating gate electrode against said fin.

Abstract: Provided herein is a process for preparing a heterocycle-functional polyoxyalkylene polyol, in which a polyoxyalkylene polyol having unsaturated groups is reacted with a heterocyclic compound. Also provided herein is a heterocycle-functional polyoxyalkylene polyol, a method of crosslinking a heterocycle-functional polyoxyalkylene polyol, a crosslinked, heterocycle-functional polyoxyalkylene polyol, and related processes.

Abstract: A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A1) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I1?2), preferred two isocyanate groups (I1=2), wherein the epoxide compound (B) comprises a epoxide compound (B1) and an epoxide compound (B2), wherein the epoxide compound (B2) is different from the epoxide compound (B1) wherein the epoxide compound (B1) comprising at least two terminal epoxide groups (F1?2), preferred two terminal epoxide groups (F1=2), linked together by a linking group (L1) and the epoxide compound (B2) comprising at least two terminal epoxide groups (F2?2)), preferred two terminal epoxide groups (F2=2), linked together by a linking group (L2), wherein the linking group (L2) comprises acyclic and covalent bonds to each other free of conjugated multiple bond

Abstract: The present invention relates to a method for producing a prepolymer that contains carbon-carbon multiple bonds, a polyol component A) being reacted with component B) that contains isocyanate groups and the polyol component comprising a polyether carbonate polyol that contains carbon-carbon multiple bonds.

Abstract: A process for preparing a phosphorus-functional polyethercarbonate polyol, comprising reacting a polyethercarbonate polyol having unsaturated groups with a phosphorus-functional compound of formula (Ia): wherein X=O or S; and wherein R1 and R2 are selected from the group consisting of C1-C22 alkyl, C1-C22 alkoxy, C1-C22 alkylsulfanyl, C6-C70 aryl, C6-C70 aryloxy, C6-C70 arylsulfanyl, C7-C70 aralkyl, C7-C70 aralkyloxy, C7-C70 aralkylsulfanyl, C7-C70 alkylaryl, C7-C70 alkylaryloxy, C7-C70 alkylarylsulfanyl, or wherein R1 and R2 are bridged to one another directly and/or via heteroatoms and are selected from the group consisting of C1-C22 alkylene, oxygen, sulfur, and NR5, wherein R5 is hydrogen, C1-C22 alkyl, C1-C22 acyl, C7-C22 aralkyl, or C6-C70 aryl radical. A process for preparing a phosphorus-functional polyurethane polymer is disclosed.

Abstract: The present invention relates to a method for producing an organooxysilyl-crosslinked polymer by reacting a polyether carbonate polyol which contains carbon-carbon double bonds with a polysiloxane compound in the presence of a suitable catalyst. Suitable polysiloxane compounds have at least two Si—H bonds. This invention also relates to organooxysilyl-crosslinked polymers which are formed by this process.

Abstract: The present invention relates to a method for producing an organooxysilyl-crosslinked polymer by reacting a polyether carbonate polyol which contains carbon-carbon double bonds with a polysiloxane compound in the presence of a suitable catalyst. Suitable polysiloxane compounds have at least two Si—H bonds. This invention also relates to organooxysilyl-crosslinked polymers which are formed by this process.

Abstract: A process for preparing polyether thiocarbonate polyols comprising the step of reacting carbon disulfide and at least one alkylene oxide in the presence of a double metal cyanide catalyst and at least one H-functional starter compound, wherein before first contact with carbon disulfide the double metal cyanide catalyst has previously been contacted with at least one alkylene oxide the the invention likewise relates to a polyol obtainable by the process according to the invention.

Abstract: A data processing system includes a plurality of subsystems, a plurality of local security controllers, and a central security controller. Each subsystem of the plurality of subsystems has a security component for providing a security function. A local security controller corresponds to each one of the subsystems. Each local security controller ensures compliance of the security component with local security policies of the subsystem to which the local security controller corresponds. The central security controller is coupled to the local security controller of each of the plurality of subsystems. The central security controller ensures data processing system compliance with system wide security policies. In the event of a detected security violation, the local security controller may respond automatically, without involvement of the central security controller. A method for securing the data processing system is also provided.

Abstract: A process for preparing halogen-containing polyoxyalkylenepolyols, comprising the step of reacting an alkylene oxide with carbon dioxide in the presence of an H-functional starter compound and of a double metal cyanide catalyst, wherein the reaction is also conducted in the presence of an ?,?-epoxy-?-haloalkane.

Abstract: Method for the production of polyoxazolidinone compounds, comprising the reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) having a pKb-value of ?9. The invention is also related to the resulting polyoxazolidinone compounds.

Abstract: The invention relates to a method for producing a polymer which contains organooxysilyl end groups. The method first has the step of reacting a polyoxyalkylene polyol which contains carbon-carbon multiple bonds with a organooxysilyl compound of the formula Si(X)n(R)4-n in the presence of a catslyst, wherein X independently of one another represents C1-C8-alkoxy, C7-C20-aralkoxy, C6-C14-aroxy, C7-C20-alkylaroxy, C1-C20-acyloxy; R independently of one another represents a saturated or unsaturated C1-C22-alkyl, C6-C14-aryl, C7-C14-aralkyl, C7-C14-alkylaryl; and n is 2, 3, or 4. The invention additionally relates to a method for producing an elastomer precursor from the polymer which contains organooxysilyl end groups and to products which can be obtained using said method.