Patents by Inventor Thomas H. King

Thomas H. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CTLA4 monoclonal antibodies and chimeric antigen receptors
    Publication number: 20240084011
    Abstract: Compositions and methods are presented in which selected polypeptide compounds bind to CTLA-4. Most typically, binding is mediated by selected VH and/or VL domains, and preferred compounds are prepared as scFv, IgG, or CAR.
    Type: Application
    Filed: June 9, 2021
    Publication date: March 14, 2024
    Inventors: Clifford Anders Olson, Shiho Tanaka, Kayvan Niazi, Melanie Hermreck, Thomas H. King, Zhimin Guo
  • Anti COVID-19 Therapies targeting nucleocapsid and spike proteins
    Publication number: 20230302121
    Abstract: Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises comprises a recombinant entity. The recombinant entity comprises a nucleic acid that encodes a nucleocapsid protein of coronavirus 2 (CoV2); and/or wherein the recombinant entity encodes a spike protein of CoV2.
    Type: Application
    Filed: May 4, 2023
    Publication date: September 28, 2023
    Applicant: NantCell, Inc.
    Inventors: Kayvan Niazi, Thomas H. King
  • INTRATUMORALLY INJECTED YEAST VACCINE
    Publication number: 20230285528
    Abstract: Disclosed herein are compositions and methods for treating solid tumors with yeast-based formulations.
    Type: Application
    Filed: March 7, 2023
    Publication date: September 14, 2023
    Inventors: Thomas H. King, Zhimin Guo, Courtney Fleenor, Melanie Hermreck
  • Yeast-based immunotherapy and type I interferon sensitivity
    Patent number: 11304996
    Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: April 19, 2022
    Assignees: The Regents of the University of Colorado, a body corporate, GlobeImmune, Inc.
    Inventors: Donald Bellgrau, Thomas H. King
  • ANTI COVID-19 THERAPIES USING NUCLEOCAPSID AND SPIKE PROTEINS
    Publication number: 20220023415
    Abstract: Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises a recombinant entity. The recombinant entity comprises a nucleic acid that encodes a nucleocapsid protein of coronavirus 2 (CoV2); and/or wherein the recombinant entity encodes a spike protein of CoV2.
    Type: Application
    Filed: September 17, 2021
    Publication date: January 27, 2022
    Inventor: Thomas H. King
  • METHODS AND COMPOSITIONS FOR MODULATING MYELOID-DERIVED SUPPRESSOR CELLS
    Publication number: 20210290708
    Abstract: The present invention includes a method and related compositions to modulate myeloid-derived suppressor cell (MDSC) suppressive function, MDSC differentiation, or combinations thereof in a cancer patient by administering a yeast comprising ?-glucans to the cancer patient, in which the yeast can be modified to unmask yeast cell wall ?-glucans to enhance the effect on MDSCs.
    Type: Application
    Filed: September 18, 2019
    Publication date: September 23, 2021
    Inventors: Patrick SOON-SHIONG, Thomas H KING
  • Modified yeast-brachyury immunotherapeutic compositions
    Patent number: 11065313
    Abstract: Disclosed are improved yeast-based immunotherapeutic compositions comprising modified Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: July 20, 2021
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Thomas H. King, Zhimin Guo, Jeffrey Schlom, Claudia Palena
  • LYSATES OF RECOMBINANT YEAST FOR INDUCING CELLULAR IMMUNE RESPONSES
    Publication number: 20210154250
    Abstract: Disclosed are methods of making immunogenic compositions comprising lysates of recombinant yeast for inducing cellular immune responses and their uses.
    Type: Application
    Filed: May 13, 2019
    Publication date: May 27, 2021
    Inventors: Thomas H. KING, Zhimin GUO, Courtney FLEENOR
  • YEAST-BASED IMMUNOTHERAPY AND TYPE I INTERFERON SENSITIVITY
    Publication number: 20200390874
    Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
    Type: Application
    Filed: August 31, 2020
    Publication date: December 17, 2020
    Inventors: Donald BELLGRAU, Thomas H. KING
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10849971
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: December 1, 2020
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Yeast-based immunotherapy and type I interferon sensitivity
    Patent number: 10799567
    Abstract: Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity to type 1 interferons (T1IFNs).
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: October 13, 2020
    Assignees: GlobeImmune, Inc., The Regents of the University of Coloradio
    Inventors: Donald Bellgrau, Thomas H. King
  • Compositions and methods for the treatment or prevention of tuberculosis
    Patent number: 10722567
    Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: July 28, 2020
    Assignees: GlobeImmune, Inc., Colorado State University Research Foundation
    Inventors: Thomas H. King, Zhimin Guo, Ian M. Orme
  • Compositions and methods for the treatment or prevention of hepatitis B virus infection
    Patent number: 10441650
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: October 15, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20190240320
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 8, 2019
    Inventors: Thomas H. KING, David APELIAN
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF TUBERCULOSIS
    Publication number: 20190151429
    Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
    Type: Application
    Filed: February 4, 2019
    Publication date: May 23, 2019
    Inventors: Thomas H. KING, Zhimin GUO, Ian M. ORME
  • Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
    Patent number: 10265393
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 23, 2019
    Assignee: GlobeImmune, Inc.
    Inventors: Thomas H. King, David Apelian
  • Compositions and methods for the treatment or prevention of tuberculosis
    Patent number: 10226522
    Abstract: Disclosed are yeast-based immunotherapeutic compositions and fusion proteins for the treatment and/or prevention of TB infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions and fusion proteins for the prophylactic and/or therapeutic treatment of TB and/or symptoms thereof.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: March 12, 2019
    Assignees: GLOBEIMMUNE, INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Thomas H. King, Zhimin Guo, Ian M. Orme
  • Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
    Publication number: 20180311339
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
    Type: Application
    Filed: March 1, 2018
    Publication date: November 1, 2018
    Inventors: David Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
  • MODIFIED YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS
    Publication number: 20180214525
    Abstract: Disclosed are improved yeast-based immunotherapeutic compositions comprising modified Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
    Type: Application
    Filed: August 1, 2016
    Publication date: August 2, 2018
    Inventors: Thomas H. KING, Zhimin GUO, Jeffrey SCHLOM, Claudia PALENA
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    Publication number: 20180177865
    Abstract: Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: June 28, 2018
    Inventors: Thomas H. KING, David APELIAN