Abstract: The present invention provides a class of pyrimidinedione cyclohekenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.

Abstract: A non-transitory computer readable medium including instructions stored thereon, when executed, the instructions being effective to cause at least one processor of a first network device to: derive a private key encryption key based on a public key, a first private key of the first network device, a second private key of a live peer device, and a Connectivity Association Key (CAK); transmit a secret key encrypted by the private key encryption key to the live peer device; and receive a communication from the live peer device, the communication being encrypted by the secret key.

Abstract: An apparatus for estimating analytics and interactive exploration of big data, stored and/or streaming, using approximate query processing is presented. The apparatus comprises a model constructor and a sampler. The model constructor identifies important predictors variables in big data using feature selection, predictor variables, and outcome variables and partitions the important predictor variables into one or more stratifications based either the identified interactions or identified relationships. The sampler generates a subset of data by querying the big data using a query constructed based on at least one stratification. The subset of data can be fed into an analytics generator. The analytics generator generates analytics data for the outcome variables based on the subset of data and an analytics algorithm and a visualization, e.g. an interactive visualization, comprising the outcome variables, the important predictor variables, the stratification, the subset of data, and the analytics data.

Abstract: Disclosed is a method of establishing secure communications. The method includes receiving an attestation parameter associated with a first peer in a potential peer-to-peer communication, adding the attestation parameter to an MACsec Key Agreement (MKA) protocol key exchange, transmitting the key exchange from the first peer to a second peer in the potential peer-to-peer communication and upon a validation of the attestation parameter by the second peer, enabling secure communication between the first peer and the second peer.

Abstract: A system for identifying information in high dimensional, low latency streaming data having dynamically evolving data patterns. The system processes, continuously and in real-time, the streaming data. Processing includes filtering the data based on event data to identify diagnostic data points by comparing the event data with an experimental design matrix and performing a modeling operation using the identified diagnostic data points in order to identify efficiently any current and emerging patterns of relationships between at least one outcome variable and predictor variables. The at least one a-priori, pre-designed experimental design matrix is generated based on combinations of the predictor variables and at least one outcome variable. The experimental design matrix is also generated based on at least one of main effects, limitations, constraints, and interaction effects of the predictor variables and combinations.

Abstract: A lifestyle service with data and routines storable in a memory of a wearable electronic device is discussed. The lifestyle service has at least a Sleep data routine and an Activity data routine. The lifestyle service can cooperate with an insight engine. The lifestyle service is aware of different types of information contained in one or more time synchronous applications. The system can compare tracked physical activity data with historical data in set increments in light of the information in the time synchronous applications and then communicate notifications to the user.

Abstract: A luminaire includes a housing, a light diffusion panel, a reflective surface, and a plurality of light sources. The light diffusion panel includes a light source aperture, an edge surface bounding the light source aperture, and an emission surface. The emission surface includes first and second emission surface sections. The second emission surface section is disposed on an opposite side of the light source aperture from the first emission surface section. The reflective surface is disposed on a side of the light diffusion panel opposite the emission surface. The light sources project light into the light diffusion panel through the edge surface. The light sources include first and second light sources. The first light source projects light into the light diffusion panel and through the first emission surface section. The second light source projects light into the light diffusion panel and through the second emission surface section.

Abstract: A system, method, and computer-readable medium for extracting the samples from big data to extract most information about the relationships of interest between dimensions and variables in the data repository. More specifically, extracting information from lame data repositories follows an adaptive process that uses systematic sampling procedures derived from optimal experimental designs to target from a large data set specific observations with information value of interest for the analytic task under consideration. The application of adaptive optimal design to guide exploration of large data repositories provides advantages over known big data technologies.

Abstract: A system for generating algorithmic models comprising a function module to generate a desirability function, an automated machine learning module, and a UI module. The desirability function defines a single desirability value based on an algorithmic model accuracy criteria, criteria for algorithmic model quality, criteria for model fidelity, and criteria for the benefits and cost of model deployment. Specific hard and soft constraints regarding these and other user-defined criteria can also be specified by the user. The automated machine learning module generates an algorithmic model by training the algorithmic model against a model data set, identifying the model with the greatest desirability with respect to all criteria as combined via the desirability function. The UI module generates a user interface to display the overall desirability as well as all model criteria configured by the user. The displayed criteria and desirability are selectable and definable.

Abstract: A system, method, and computer-readable medium for performing a variable and interaction detection operation. In certain embodiments, the variable and interaction detection operation detects important variables and as well as interactions among certain important variables in big data. In certain embodiments, the variable and interaction detection operation includes a robust automated process flow (i.e., an analytic recipe) which identifies important variables and their interactions in large data sets.

Abstract: The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.

Abstract: A system including a first luminaire housing, a second luminaire housing, and a controller. The first luminaire housing includes a first light source configured to provide illumination to a first location, and a first I/O device configured to sense a first data set corresponding the first location. The second luminaire housing is separate from the first luminaire housing and includes a second light source configured to provide illumination to a second location, and a second I/O device configured to sense a second data set corresponding to the second location. The controller is configured to receive a portion of the first data set and a portion of the second data set, combine the portion of the first data set and the portion of the second data set to form a third data set corresponding to the first location and second location, and output the third data set.

Abstract: The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.

Abstract: A system, method, and computer-readable medium for extracting the samples from big data to extract most information about the relationships of interest between dimensions and variables in the data repository. More specifically, extracting information from lame data repositories follows an adaptive process that uses systematic sampling procedures derived from optimal experimental designs to target from a large data set specific observations with information value of interest for the analytic task under consideration. The application of adaptive optimal design to guide exploration of large data repositories provides advantages over known big data technologies.

Abstract: A sheath at the end of an endoscope may be elastically expanded to clear an area within a body cavity during a medical procedure and retracted to within an envelope of the endoscope when not in use. In the expanded state, the sheath may provide sufficient mechanical strength to clear space for a camera or surgical tool, while also having sufficient pliability to mitigate impact on surrounding, sensitive tissue. In an example embodiment, the sheath may be an elastomeric sheath or the like coupled between portions of coaxial shafts of an endoscope, and the coaxial shafts can move relative to one another to deploy or retract the sheath by relatively tensioning and relaxing opposing ends of the sheath. In this manner, the sheath may be selectively expanded and retracted without exposed moving parts or sharp edges.

Abstract: In a first enclave of a label switching network (LSN), a protocol data unit (PDU) of the LSN is formatted to include a network service field specifying a service to be applied to the PDU. The service field can be positioned between PDU data link layer and network layer fields. The PDU specifies PDU routing/forwarding information for a path in the LSN ending in an LSN second enclave, and routing/forwarding for a destination between path segments in a non-LSN. The PDU is communicated from the first enclave, via the non-LSN, to the second enclave in accordance with the routing/forwarding information for the destination between path segments in the non-LSN. In the second enclave, each network service specified for the PDU is determined and then applied to the PDU. The second enclave transmits the network serviced PDU from the second enclave in accordance with the routing/forwarding information of the PDU in the label switching network.

Abstract: A lifestyle service with data and routines storable in a memory of a wearable electronic device is discussed. The lifestyle service has at least a Sleep data routine and an Activity data routine. The lifestyle service can cooperate with an insight engine. The lifestyle service is aware of different types of information contained in one or more time synchronous applications. The system can compare tracked physical activity data with historical data in set increments in light of the information in the time synchronous applications and then communicate notifications to the user.

Abstract: This invention relates to a pharmaceutical composition comprising or consisting essentially of the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD). The composition is particularly safe and efficacious for use in the treatment of neurological conditions, characterized by hyper-excitability of the central nervous system, convulsions or seizures such as occur in epilepsy. Preferably the CBDV and the CBD are present with at least one non-cannabinoid component of cannabis such as one or more terpenes or a terpene fraction. More particularly the composition further comprises one or more cannabichromene type compounds. Particularly cannabichromene propyl variant (CBCV) and/or cannabichromene (CBC).

Abstract: In a first enclave of a label switching network (LSN), a protocol data unit (PDU) of the LSN is formatted to include a network service field specifying a service to be applied to the PDU. The service field can be positioned between PDU data link layer and network layer fields. The PDU specifies PDU routing/forwarding information for a path in the LSN ending in an LSN second enclave, and routing/forwarding for a destination between path segments in a non-LSN. The PDU is communicated from the first enclave, via the non-LSN, to the second enclave in accordance with the routing/forwarding information for the destination between path segments in the non-LSN. In the second enclave, each network service specified for the PDU is determined and then applied to the PDU. The second enclave transmits the network serviced PDU from the second enclave in accordance with the routing/forwarding information of the PDU in the label switching network.

Abstract: The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.