Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) alpha-isoform specific PI3K inhibitor and (b) a B-RAF inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific PI3K inhibitor, (b) a cyclin dependent kinase 4/6 (CDK4/6) inhibitor, and (c) an antimetabolite antineoplastic agent; combined preparations and pharmaceutical compositions thereof; the uses of such a combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) an Mdm2 inhibitor and (b)(i) a MEK inhibitor and/or (b)(ii) Bcl2 inhibitor, particularly for use in the treatment of a cancer. This disclosure also relates to uses of such combination for preparation of a medicament for the treatment of a cancer; methods of treating a cancer in a subject in need thereof comprising administering to said subject a jointly therapeutically effective amount of said combination; pharmaceutical compositions comprising such combination and commercial packages thereto.

Abstract: Implementations relate to suggested items for use with embedded applications in chat conversations. In some implementations, a method includes causing a chat interface to be displayed by a first user device, the chat interface generated by a messaging application. The chat interface is configured to display, in a chat conversation, messages provided by user devices participating in the chat conversation over a network. An embedded interface is associated with the chat interface and displayed by an embedded application associated with the messaging application. A suggestion event is determined to occur in association with the embedded application based on received data that indicates that a particular event has occurred at one or more other user devices participating in the chat conversation. Suggested response items are obtained based on the suggestion event, and the suggested response items are displayed by the first user device.

Abstract: Implementations relate to embedded programs and interfaces for chat conversations. In some implementations, a method includes initiating an embedded application in association with a chat interface displayed by a messaging application that executes at least in part on a first user device. The chat interface displays messages originating from other user devices participating in a chat conversation over a network and associated with chat users. An indication is received over the network that one or more particular devices of the other user devices have connected to an embedded session associated with the embedded application. In response, chat identities associated with particular users of the particular user devices are provided from the messaging application to the embedded application. The particular users are designated as member users of the embedded session, and the embedded application is updated based on data received from particular user devices of the embedded session.

Abstract: The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific PI3K inhibitor, (b) an MDM2 inhibitor, and optionally (c) a BCL-2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer a subject in need thereof comprising administering a therapeutically effective amount of such combination.

Abstract: An integral transmission; comprising a driving gear connected to a driving shaft for co-joint rotation, a large gear engaging with the driving gear, a first driven gear engaging with the large gear, and at least one additional driven gear which engages with the driving gear; wherein an axis of rotation of the driving gear and an axis of rotation of the first driven gear engaging with the large gear are arranged in a plane of alignment, an axis of rotation of the large gear is offset in the vertical direction with respect to the plane of alignment, and an axis of rotation of the at least one additional driven gear engaging with the driving gear is located in the plane of alignment. A geared compressor system; comprising the integral transmission and a drive unit.

Abstract: Encapsulated probiotic compositions that deliver a minimum of 5 Billion CFU/capsule in potency and a minimum of at least 1 probiotic strain with clinical efficacy throughout shelf life are disclosed herein. In some embodiments, the encapsulated probiotic compositions meet the USDA certified organic labeling requirement, including 5% or less of non-organic materials.

Abstract: The present disclosure pertains to a pharmaceutical combination comprising (a) alpha-isoform specific PI3K inhibitor and (b) an AKT inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject in need thereof comprising administering a therapeutically effective amount of such combination.

Abstract: The present disclosure relates to pharmaceutical combinations comprising a cyclin dependent kinase 4/6 (CDK4/6) inhibitor compound, (b) a B-Raf inhibitor compound, and optionally (c) an alpha-isoform specific phosphatidylinositol 3-kinase (PI3K) inhibitor compound, for the treatment or prevention of cancer, as well as related pharmaceutical compositions, uses, and methods of treatment or prevention of cancer.

Abstract: The present disclosure relates to pharmaceutical combinations comprising (a) a cyclin dependent kinase 4/6 (CDK4/6) inhibitor compound, and (b) an epidermal growth factor receptor (EGFR) inhibitor, for the treatment or prevention of cancer. The disclosure also provides related pharmaceutical compositions, uses, and methods of treatment or prevention of cancer.

Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) alpha-isoform specific PI3K inhibitor and (b) a B-RAF inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific P13K inhibitor, (b) a cyclin dependent kinase 4/6 (CDK4/6) inhibitor, and (c) an antimetabolite antineoplastic agent; combined preparations and pharmaceutical compositions thereof; the uses of such a combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: A combination of a CDK4/6 inhibitor and a MEK inhibitor for the treatment of diseases such as cancer.

Abstract: The technology described herein is capable of generating and presenting graphical user interfaces for displaying shared content, configuring space objects (also simply called spaces), posting digital content items to various spaces, inviting other users to contribute digital content items to various spaces, forking digital content items posted in one space or post object to another space or post object, contextual searching, posting rich comments in association with a post including graphical and textual data, and so forth. Further, the technology may provide suggestive search based on the spaces associated with a user, generate and exchange data with other nodes on a computer network, generate notification data including notifications reflecting updates posted to spaces by various users, and coalesce related comments to reduce number of notifications that each user receives and/or through which a user may have to navigate or scroll through.

Abstract: One variation may include an electrical connection terminal (20) including at least a first weld tab (22). The first weld tab (22) including an outer face (23) and a weldable inner face (33). The weldable inner face (33) includes a substantially planar first portion (25) and a substantially planar second portion (27), and wherein the first portion (25) and second portion (27) are not in the same plane. Another variation may include an electrical connection post (56) having a first post portion (64) and a second post portion (404), the first post portion having a first width and the second post portion having a second width, and wherein the first width is greater than the second width.