Abstract: The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17 A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17 A antagonists (inhibit the activities of IL-17 A and IL-17 AF) and are capable of inhibiting IL-17 A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for said antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL 17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.

Abstract: The present invention provides for a fluid transfer device for interconnecting vessels, the fluid transfer device comprising a main body with a first body part providing a first hollow interior merging into a first open end for receiving a fluid obtaining vessel, and a second body part providing a second hollow interior merging into a second open end for receiving a fluid supplying vessel, a connection assembly with a double-ended cannula for connecting the first hollow interior with the second hollow interior, and a first encasing member encasing a first cannula part arranged within the first hollow interior, and an actuating member provided inside the first hollow interior, wherein the actuating member is movably arranged along a longitudinal axis of the first body part, and wherein the actuating member is in contact with the first encasing member for piercing the first encasing member by the cannula during a movement of the actuating member towards the second body part.

Abstract: A blister package is disclosed herein. The blister package includes a body, a plurality of pockets, and a top seal. The body has a top surface and a bottom surface opposite the top surface. The plurality of pockets is formed in the body. Each of the plurality of pockets extend below the top surface of the body. Each pocket of the plurality of pockets is configured to hold a pharmaceutical. The plurality of pockets is arranged in a manner that defines at least one dose. The plurality of pockets for the at least one dose includes a first pocket in parallel with a second pocket, and a third pocket perpendicular to the first pocket and the second pocket. The top seal is configured to interface with the body. The top seal is configured to hold the pharmaceutical in each respective pocket.

Abstract: A cartridge system for an eccentric screw pump, comprising a cartridge for receiving a medium to be dosed, a stator being provided on the cartridge, which cooperates with a rotor unit of the eccentric screw pump for dosing the medium, and a plug being movably supported in the cartridge for a fluid-tight closure of the cartridge, wherein the plug comprises a rotor breakthrough through which the rotor unit can be passed.

Abstract: A bearing assembly includes a shaft, a first bearing, and a nut. The nut has a thread, which is screwed onto a threaded region formed on the shaft, and a bearing seat formed on the shaft adjoins the threaded region. The inner ring of the first bearing contacts the bearing seat, and the nut contacts the inner ring of the first bearing. The inner ring of the first bearing is arranged spaced apart from the threaded region of the shaft. A runout region of a thread cut into the threaded region of the shaft is arranged in a subsection of the bearing seat adjoining the threaded region.

Abstract: An electrical plug forms an electrical plug connection to a coupling that is complementary to the plug. The electrical plug includes a plurality of metal contact elements for electrically contacting an electrical apparatus arranged in a housing, a contact carrier element and a receiving element for receiving the coupling in a receiving space surrounded by the receiving element. The receiving element can be introduced into the housing in a first direction through an opening in the housing. The receiving element, to form the plug, can be brought into engagement in the first direction with the contact carrier element, the contact elements being guided through the contact carrier element and having contact regions which, when the receiving element has been brought into engagement with the contact carrier element, extend into the receiving space, away from the contact carrier element, counter to the first direction.

Abstract: The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17 A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17 A antagonists (inhibit the activities of IL-17 A and IL-17 AF) and are capable of inhibiting IL-17 A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for said antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL 17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.

Abstract: A processing chamber includes a chamber body, a substrate support configured to hold a substrate in place, and a pre-heat ring having a central opening sized to be disposed around the substrate. A process gas inlet is configured to direct process gas in a lateral direction to flow over the pre-heat ring and the substrate. A process gas flow deflector includes a radially outer mounting portion and a radially inner blade-shaped process gas deflection portion extending in a radial direction. The radially inner blade-shaped process gas deflection portion is shaped as a ring segment. The radially inner blade-shaped process gas deflection portion is disposed above the process gas inlet and dimensioned to overlap with the pre-heat ring, wherein a degree of overlap between the pre-heat ring and process gas flow deflector in the radial direction is at least ½ of the radial dimension of the pre-heat ring.

Abstract: Disclosed is a construction box system 10 for a 3D printer 12, comprising a construction box 30 having a side wall structure 32 and a construction platform 34 received within the side wall structure 32, the side wall structure 32 limiting an upwardly open construction box interior space 36 for building up a component by 3D printing, which interior space is downwardly limited by the construction platform 34, and a support structure 50 comprising its own drive 52 integrated into the support structure 50 and to which the construction box 30 is releasably attachable, such that the construction box 30 can be repeatedly removed from the support structure 50 after building up the component in the construction box interior space 36 and subsequently reattached to the support structure 50.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of titanium diboride. There is also described a method of manufacturing the component and the application of TiB2 as a release agent in high-temperature applications.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of yttria. There is also described a method of manufacturing a coated component, and the application of Y2O3 as a release agent in high temperature applications.

Abstract: A method, a computer system, and a computer program product for creating medical findings reports are introduced. Using these, hierarchically organized and dynamically adaptable data structure and a text editing interface are provided. A report text consisting of user-entered free text and/or structured text, that is stored in the data structure elements and transferred into the report text, is created. In the report text, first report text elements, that can be assigned to at least one data structure element, and second report text elements, that cannot be assigned to any of the existing data structure elements, are identified. The first report text elements are then assigned to the at least one data structure element. The second report text elements are then assigned and stored to one or more newly created data structure elements and/or to existing data structure elements while maintaining the order of the report text.

Abstract: A cartridge system for an eccentric screw pump, comprising a cartridge for receiving a medium to be dosed, a stator being provided on the cartridge, which cooperates with a rotor unit of the eccentric screw pump for dosing the medium, and a plug being movably supported in the cartridge for a fluid-tight closure of the cartridge, wherein the plug comprises a rotor breakthrough through which the rotor unit can be passed.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: A semiconductor substrate includes a semiconductor base substrate. An alignment structure is formed on a surface of the semiconductor base substrate. An epitaxial layer is deposited on the surface of the semiconductor base substrate. The alignment structure includes an area of the surface of the semiconductor base substrate that is formed as a groove pattern. Grooves of the groove pattern are aligned with a specific crystallographic direction of the semiconductor base substrate. The specific crystallographic direction provides for a slower epitaxial growth rate on such a groove-patterned base substrate surface area compared to epitaxial growth on a surface of the semiconductor base substrate adjacent to the groove-patterned area.

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: A bearing assembly includes a shaft, a first bearing, and a nut. The nut has a thread, which is screwed onto a threaded region formed on the shaft, and a bearing seat formed on the shaft adjoins the threaded region. The inner ring of the first bearing contacts the bearing seat, and the nut contacts the inner ring of the first bearing. The inner ring of the first bearing is arranged spaced apart from the threaded region of the shaft. A runout region of a thread cut into the threaded region of the shaft is arranged in a subsection of the bearing seat adjoining the threaded region.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

Abstract: Disclosed is a coater assembly 1 for a 3D printer, comprising a coater 3 having a container 5 which defines an inner cavity for receiving particulate construction material which opens into a container opening 7 for outputting the particulate construction material from the container 5, and an output region 9 which defines a coater output opening 11 for outputting the particulate construction material from the coater 3 onto a construction field. The container 5 is movable relative to the coater output opening 11 so that by moving the container 5 relative to the coater output opening a discharge of particulate construction material from the inner cavity through the container opening 7 and the coater output opening 11 onto the construction field is variable.