Abstract: The invention relates to a drill rod magazine for vertical storage of drill rod elements, having a base frame, on which at least one support means is arranged that has two substantially horizontally directed retaining arms which, by formation of a receiving area, are parallel to and spaced apart from each other, wherein the drill rod elements are retained in a vertical position between the retaining arms. Along at least one retaining arm a clamping rod is supported in a movable manner which is in operative connection with a tensioning means that exerts a tensioning force onto the drill rod elements for retaining the drill rod elements in a clamping manner in the receiving area.

Abstract: This invention is in the field of IGF-1 modifications. In particular, it relates to modified IGF-polypeptides and modified IGF-1 precursor polypeptides wherein the cleavage of E-peptide is prevented. The invention also relates to the use of such polypeptides for treating muscle diseases and disorders.

Abstract: In a thrust washer for the axial securing of rolling elements of a bearing, and a gear mechanism including a thrust washer, the thrust washer is arranged as a circular disk, which has an axially protruding, in particular radially outer, projection. The circular disk has a recess, which is disposed out of center, i.e., the center point of the, e.g., circular recess thus particularly being set apart from the center axis and/or from the center point of the circular disk. The projection may have an annular shape, and the ring axis is set apart from the center point of the, e.g., circular recess.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: A method for adjusting at least one means of an inserting apparatus adjusted for processing envelopes according to at least one predetermined dimension of the envelope is described. A plurality of envelopes is measured, while the envelopes are moved to obtain at least one predetermined dimension of the envelope. Depending on a comparison of the obtained dimension with the adjusted dimension and/or with one or several previously obtained dimensions, at least one means of the inserting apparatus is adjusted for processing the envelopes.

Abstract: Drive mechanism (1) for a motor vehicle (6), comprising a dual clutch transmission (10) that includes a first powertrain (13), which can be connected to a first drive unit (2) via a first clutch (21), and a second powertrain (14), which can be connected to the first drive unit (2) via a second clutch (22), the first powertrain (13) being securely coupled to a second drive unit (3); when shifting gears in the dual clutch transmission (10), the second drive unit (3) supplies a predefined drive torque.

Abstract: Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.

Abstract: In various example embodiments, a system and method for automatic localization of advertisements is provided. In example embodiments, a transmission signal is received. A portion of the transmission signal is identified. A determination of whether localized advertisement data corresponds to the identified portion is performed. Localized advertisement data that correspond to the identified portion of the transmission signal is retrieved. The localized advertisement data is then inserted into the identified portion of the transmission signal to generate an altered signal. The altered signal is transmitted to a user device.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17 A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17 A antagonists (inhibit the activities of IL-17 A and IL-17 AF) and are capable of inhibiting IL-17 A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for said antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL 17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: In example embodiments, a system and method for providing interactive advertisement is provided. In some embodiments, a component causes a video program having an interactive advertisement to be displayed to a user on a display screen. The interactive advertisement includes an enhanced content activator. In response to activation of the enhanced content activator by the user, enhanced advertisement information including at least one trigger is provisioned. The enhanced advertisement information is then caused to be displayed with the video program and the interactive advertisement. A selection by the user of the at least one trigger associated with the enhanced advertisement information is monitored. In response to selection of the at least one trigger, access to further content associated with the enhanced content information is provided.

Abstract: The invention relates to a drill rod magazine for vertical storage of drill rod elements, having a base frame, on which at least one support means is arranged that has two substantially horizontally directed retaining arms which, by formation of a receiving area, are parallel to and spaced apart from each other, wherein the drill rod elements are retained in a vertical position between the retaining arms. Along at least one retaining arm a clamping rod is supported in a movable manner which is in operative connection with a tensioning means that exerts a tensioning force onto the drill rod elements for retaining the drill rod elements in a clamping manner in the receiving area.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

Abstract: A floor module for an aircraft cargo hold including a cover element and a floor element which is spaced apart from the cover element at least in some segments and which is attached to an underside of the cover element. The cover element includes receiving openings for receiving ball elements. The cover element and the floor element can be formed as a hybrid composite part.

Abstract: A mounting device for mounting functional devices within a cargo hold of an aircraft. The mounting device includes at least one surface unit and a plurality of functional devices which can be mounted on the surface unit in such a way that the surface unit can be inserted together with functional devices mounted thereon into the aircraft cargo hold in the manner of a template in such a way that all the functional devices come to lie in defined mounting locations in the cargo hold and can be mounted on supporting structures of the aircraft or the cargo hold without adjustment in relation to the surface unit.

Abstract: The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17 A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17 A antagonists (inhibit the activities of IL-17 A and IL-17 AF) and are capable of inhibiting IL-17 A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for the antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL 17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.

Abstract: A method for determining a fluid composition parameter, e.g., a fluid identifier, a mixing ratio or a parameter describing heat transfer properties, of an unknown fluid in a mass flow controller is disclosed. A control valve of the mass flow controller is set so as to establish a constant flow, preferably zero flow, through the mass flow controller. A heating element of the flow sensor is heated, and at least one temperature value is measured with temperature sensors arranged on both sides of the heater while the fluid contacts the flow sensor. First calibration data (LUT1) are retrieved. The first calibration data have, as input values, temperature values measured with the flow sensor at the previously established constant flow and have, as output values, values of the fluid composition parameter. The first calibration data are used to determine the fluid composition parameter from the measured temperature value.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.