Abstract: Compounds of fomula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, and Zn.sup.+2, or represents 2 H.sup.+ each H.sup.+ bonded to one of the N atoms connected by the solid lines;R.sup.1 is a saturated or unsaturated hydrocarbyl residue of 8-25C;each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, andX is COOR.sup.3, wherein R.sup.3 is alkyl (1-4C);are useful in photodynamic therapy and diagnosis.These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.

Abstract: The invention provides a vehicle battery system including a main and a reserve battery disposed within a battery housing (10) having conventional external dimensions and battery terminal locations. An illustrated embodiment includes a main battery, comprising a series of thin, flat cells (38) disposed along a first axis, and a reserve battery, comprising a series of cells (42) disposed along a second axis transverse to the first axis. An electrical circuit facilitates selective communication between the reserve battery and the vehicle starter in accordance with the position of a switch assembly (100). An electrically conductive fastener is disposed to simultaneously maintain electrical communication between a main battery termination and an external battery terminal and also between a reserve battery termination and the same external battery terminal.

Abstract: A simple, optimized lead-acid battery includes a stack of a plurality of film pouches, each containing positive and negative electrode elements and separators. The pouches are prepared by folding an elongate film strip, and collector tabs are provided for the electrodes at either end of the stack. Electrode pairs intermediate the ends of the stack are electrically connected through adjoining openings in the pouch walls, e.g. be welding. In the most preferred embodiment, an integral vent is formed from flaps cut in the film strip and the pouch edges and top are heat sealed for electrolyte containment.

Abstract: The present invention relates to a unique battery arrangement including battery plates having a pair of spaced apart battery lugs for both the positive and negative plates. While being spaced apart, the lugs are located generally adjacent one top edge of the plates; on opposite sides for the positive and negative plate constructions. The straps used to electrically connect the lugs are lower in height than those used on current battery designs, providing excellent current collection, efficient fusion with smaller lugs and resistance to vibration caused by separation of the lugs from the straps. The present invention also features plates having greater plate surface area, improved current carrying capability and reduced voltage drop. A weld element couples straps of like polarity, and in the preferred embodiment, at least a portion of the weld element is located intermediate the ends of the straps.

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.

Abstract: New classes of photosensitizing compounds useful in photodynamic therapy are disclosed. These compounds are simplified dimers and polymers of monohydroxy deuteroporphyrins, hydrophobic ethers of these monomers, and red light-absorbing derivatives of methyl pheophorbide-a.

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.

Abstract: A photosensitizing composition prepared by recovering a portion of hematoporphyrin derivative which has aggregate weight of more than 10 kd is useful in locating tumor tissue to which this improved photosensitizing drug homes. In the invention method, the subject is administered the improved drug and sufficient time is allowed to pass to permit accumulation of the drug in tumor tissue. The subject is then illuminated at suspected sites with radiation capable of absorption by the improved drug and which radiation produces fluorescence by the drug. Detection of the intensity of fluorescence indicates the quantity of drug at the measured location and permits assessment as to whether a tumor is present at that location.

Abstract: New classes of photosensitizing compounds useful in photodynamic therapy are disclosed. These compounds are simplified dimers and polymers of monohydroxy deuteroporphyrins, hydrophobic ethers of these monomers, and red light-absorbing derivatives of methyl pheophorbide-a.

Abstract: The invention provides a vehicle battery system including a main and a reserve battery disposed within a battery housing (10) having conventional external dimensions and battery terminal locations. An illustrated embodiment includes a main battery, comprising a series of thin, flat cells (38) disposed along a first axis, and a reserve battery, comprising a series of cells (42) diposed along a second axis transverse to the first axis. An electrical circuit facilitates selective communication between the reserve battery and the vehicle starter in accordance with the position of a switch assembly (100). The circuit illustratively includes a diode (110) configured to permit current flow into the reserve battery (104) during recharging, but which prevents reserve battery drain during normal vehicle operation. A variable resistor (112) is disposed in series with the diode to limit the amount of power, and hence the amount of heat, dissipated by the diode.

Abstract: A battery module for insulating a battery from the heat of the engine of a motor vehicle, the module including a battery compartment, an air inlet and an air outlet, a first air flow path connecting the air inlet to the air outlet and a second air flow path around the outside of the battery compartment connecting the air inlet to the air outlet, a damper positioned in the housing for movement between a first position wherein the first air flow path is open and the second air flow path is closed and a second position wherein the first air flow path is closed and the second air flow path is open, a shape memory alloy member for moving the damper from the first position to the second position when the ambient temperature exceeds a predetermined minimum and a spring for biasing the damper to the first position when the ambient temperature is less than the predetermined temperature.

Abstract: Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula ##STR1## wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.

Abstract: To provide to and receive radiation from a photodynamic drug in neoplastic tissue, a laser system transmits radiation through an interface into a radiation delivery system, which is in juxtaposition with neoplastic tissue containing a photodynamic drug. The laser system may be a single argon laser pumping a dye laser, two parallel sets of argon lasers pumping a dye laser, a krypton laser or a xenon laser. In addition to transmitting radiation from the laser to the delivery system, the interface system may: (1) direct a portion of the light back to the laser's power supply to control the intensity of the radiation emitted from the laser; and/or (2) receive light from the light conductors of the delivery system. The interface channels light to radiation sensing devices which are either from a beam splitter indicating the magnitude of the radiation delivered from the laser system to the radiation delivery system or radiation leaking through the light conductor.

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.

Abstract: A 24/12 volt battery power supply for a vehicle includes two 12 volt batteries connected in series, and having first and second 24 volt terminals to the opposite ends of the batteries and a 12 volt terminal to the center common connection of the batteries. The 12 volt loads are divided into equal right and left side vehicle loads and the right side is connected across one battery and the left side is connected across the second battery. A three phase wye-connected alternator has the winding connected to a full wave three phase rectifier, the D.C. output of which is connected to the 24 volt terminals. The center common connection of the winding is connected directly to the 12 volt terminal. The system operates with balanced currents and charges on the two 12 volt batteries so long as the 12 volt loads remain balanced.

Abstract: The interface between the plastic cover of a battery container and the lead or other metal terminal post which extends therethrough is sealed with a rubber bushing which is compressed and extruded along the terminal post during installation and locked tightly in its compressed and extruded state. The bushing preferably has a pair of oppositely angled intersecting frustoconical surfaces on its exterior surface which are adapted to cooperate with mating surfaces surrounding the opening in the cover and on a locking retainer. The assembly provides a flexible seal which will accommodate the inevitable vertical movement of the terminal post as a result of battery element expansion. Most importantly, the assembly provides an extremely effective barrier to the migration of electrolyte along the terminal post to prevent outer terminal corrosion.

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.

Abstract: A process for the gasification of coal consisting essentially of forming a free-burning arc discharge between at least one anode and a cathode having a conical tip, wherein said arc discharge forms a contraction of the current-carrying area in the transition region in the vicinity of the cathode, forcefully projecting a reactive material consisting of a mixture of pulverized coal and steam parallel to the surface of said conical tip of said cathode and through said contraction of the current-carrying area in the transition region in the vicinity of the cathode, at such a rate that said mixture of pulverized coal and steam is exposed to the free-burning arc for less than 3 milli-seconds, and recovering a solid carbonaceous fume having a surface area equivalent to a particle size in the range of 0.01 to 0.2 microns and a gaseous product comprising of hydrogen, carbon monoxide and carbon dioxide.