Abstract: This disclosure relates to phosphoinositide 3-kinases (PI3Ks) inhibitors such as N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)sulfonamide derivatives and uses related thereto. In certain embodiments, the disclosure relates to methods of treating PI3K associated diseases or conditions comprising administering an effective amount of a compound disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, suffering from, or diagnosed with cancer or a hematological malignancy.

Abstract: The invention relates to a child safety seat (100) adapted to be secured with a safety belt (40) of a vehicle, comprising a seat shell (20) for receiving a child; and a seat base (10) for being placed on a seat of the vehicle. The seat base (10) comprises a base member (1) coupled to the seat shell (20); a pivoting component (2) connected pivotably to the base member (1); and an engaging member (3) configured to engage with the safety belt (40) of the vehicle, wherein the engaging member (3) is coupled to the pivoting component (2) such that a movement of the engaging member (3) in a certain direction relative to the base member (1) causes the pivoting component (2) to pivot away from the base member (1).

Abstract: A battery module (5) for a motor vehicle. The battery modue (5) includes a battery unit (2), a negative pole (21), a positive pole (22), a switching unit (60), which is connected electrically in series with the battery unit (2) and has at least one controllable switching element, and a management system (30) for controlling the at least one switching element. A hold circuit (40) is provided, which is connected to the management system (30) and to the switching unit (60) in such a way that a control signal from the management system (30) can be transferred through the hold circuit (40) to the switching unit (60), and is designed such that, in an active state of the hold circuit (40), a control signal from the management system (30) to open the at least one switching element can be transferred to the switching unit (60) with a time delay.

Abstract: Absorbent cores for use in absorbent articles are presented. The absorbent cores include a low-density zone that is surrounded by zones having a higher density than that of the low-density zone. The low-density zone aids in fluid absorption, distribution and storage.

Abstract: A seat base, for a child safety seat, adapted to be secured with a safety belt of a vehicle, includes a base member configured to be placed on a seat of the vehicle, and a positioning element rigidly attached to the base member. The positioning element extends vertically from the base member. The positioning element an engaging member adapted to engage with the safety belt. The engaging member is coupled to the positioning element above the upper surface of the base member at a distance, and the engaging member is kept by the positioning element at the distance from the base member. A child safety seat including such a seat base is also provided.

Abstract: The aim of the invention is the simple operation and handling of a fire basket (1) for wood and similar combustibles, comprising a heat-resistant bottom for forming a fire pan and a jacket adjoining the same in the upward direction. This aim is achieved, according to the invention, in that the jacket (3) is in the form of a stacking crate (4) made of sheet metal. At least one bottle opener (5) is preferably provided in the jacket (3), in particular punched in or cut out adjacent to the corner region of the beverage crate, and spacers (6), in particular for beverage bottles, are inserted in the stacking crate (4) upon delivery.

Abstract: For a stable, easy-to-handle fire basin for burning wood and similar fuels, consisting of a plurality of segments (1a) which are supported on the ground with feet (2) and towards the top have a plurality of segment surfaces (1b) to form the tub-shaped fire basin (1), the invention proposes that the segment surfaces (1b) of the fire basin (1) also have or form concave depressions or recesses.

Abstract: In order to improve the safety and handling of a brazier (1) for burning wood and similar fuels, comprising a substantially pot-shaped basket (2) and a fire pan (4), it is suggested that the fire pan (4) is mounted on the basket (2) such that these can pivot relative to one another, particularly tipping by 180° or “overend” from the operating position into a fire-extinguishing position, the basket (2) that lies above when in said extinguishing position serving as the cover hood that puts out the fire. This brazier can also be in the form of a tea light, a standard or table lamp or a pendant lamp.

Abstract: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

Abstract: Absorbent laminates and multi-layer, folded absorbent cores comprising the absorbent laminates for use in absorbent articles are presented. Specifically, multi-layer, folded absorbent cores are presented that are formed from an absorbent laminate comprising an absorbent layer between two tissue layers, in which the absorbent core includes a central channel running longitudinally along the core and crenellations profiled along the thickness of the core and providing enhanced liquid distribution across the core surface area or profile and improved liquid absorption into the laminate.

Abstract: The present invention relates to a circuit arrangement for switching a high-voltage MOSFET (7) for precharging an intermediate circuit capacitance of a high-voltage on-board network with a first circuit assembly (11), by means of which the switching times of a high-voltage MOSFET used for charging the intermediate circuit capacitance can be reduced.

Abstract: Absorbent laminates and multi-layer, folded absorbent cores comprising the absorbent laminates for use in absorbent articles are presented. Specifically, multi-layer, folded absorbent cores are presented that are formed from an absorbent laminate comprising an absorbent layer between two tissue layers, in which the absorbent core includes a central channel running longitudinally along the core and crenellations profiled along the thickness of the core and providing enhanced liquid distribution across the core surface area or profile and improved liquid absorption into the laminate.

Abstract: Disposable absorbent articles, and methods of making such articles that comprise one or more back ears or closure members that are configured to permit the article to be adjusted for a particular user.

Abstract: This disclosure includes embodiments of disposable absorbent articles and methods of making disposable absorbent articles that include closures with a web of material and hook fasteners that are unitary with the web. For example, some of the present disposable absorbent articles include diapers or briefs with closure members, such as back ears or front ears, defined at least in part by a nonwoven web with hook fasteners that are unitary with the nonwoven web. Use of such unitary hook fasteners allows simpler construction of such articles and/or softer closure members for improved fit and user comfort, and/or other benefits. Certain embodiments of the present methods can manufacture such absorbent articles with fewer manufacturing steps or processes and/or fewer raw materials, relative to those required to manufacture prior art absorbent articles with hook fastener patches that are added by application of a separate piece of material that includes the hook fasteners.

Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

Abstract: The present invention relates to a circuit arrangement for switching a high-voltage MOSFET (7) for precharging an intermediate circuit capacitance of a high-voltage on-board network with a first circuit assembly (11), by means of which the switching times of a high-voltage MOSFET used for charging the intermediate circuit capacitance can be reduced.

Abstract: The invention concerns a method for production of components comprising a Schottky diode by means of printing technology. The method involves a step of application and deposition of a semiconductor-nanoparticle dispersion on a first electrode, which is disposed on a substrate, the step of exposure to laser light of the deposited semiconductor-nanoparticle dispersion to form a mu-cone with a bottom and a tip, wherein the bottom of the mu-cone is joined to the first electrode, the step of embedding the thus-formed mu-cone in an electrically insulating polymer matrix, and the step of applying a second electrode, so that the tip of the mu-cone is joined to the second electrode.

Abstract: A seat base, for a child safety seat, adapted to be secured with a safety belt of a vehicle, includes a base member configured to be placed on a seat of the vehicle, and a positioning element rigidly attached to the base member. The positioning element extends vertically from the base member. The positioning element comprises an engaging member adapted to engage with the safety belt. The engaging member is coupled to the positioning element above the upper surface of the base member at a distance, and the engaging member is kept by the positioning element at the distance from the base member. The invention further relates to a child safety seat comprising such a seat base.

Abstract: This disclosure relates to phosphoinositide 3-kinases (PI3Ks) inhibitors such as N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)sulfonamide derivatives and uses related thereto. In certain embodiments, the disclosure relates to methods of treating PI3K associated diseases or conditions comprising administering an effective amount of a compound disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, suffering from, or diagnosed with cancer or a hematological malignancy.

Abstract: The invention relates to a child safety seat (100) adapted to be secured with a safety belt (40) of a vehicle, comprising a seat shell (20) for receiving a child; and a seat base (10) for being placed on a seat of the vehicle. The seat base (10) comprises a base member (1) coupled to the seat shell (20); a pivoting component (2) connected pivotably to the base member (1); and an engaging member (3) configured to engage with the safety belt (40) of the vehicle, wherein the engaging member (3) is coupled to the pivoting component (2) such that a movement of the engaging member (3) in a certain direction relative to the base member (1) causes the pivoting component (2) to pivot away from the base member (1).