Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.

Abstract: A construction machine, in particular a road paver or tandem roller, for working a ground in a working direction, having a machine frame, an operator platform with at least one operator platform door and at least one travel unit, and an operating unit, the operating unit comprising an operator's seat for an operator of the construction machine, an operating console with operating elements for controlling the construction machine by the operator, a support structure on which both the operator's seat and the operating console are arranged, and a transverse guide with at least one guide rail, wherein the support structure is movably mounted on the at least one guide rail, so that the support structure together with the operator's seat and the operating console are configured to be movable along the at least one guide rail, wherein the support structure is configured such that it can be swiveled together with the operator's seat and the operating console about a swivel axis running in particular in vertical direc

Abstract: A probe head with a cylindrical portion and an oblique truncated portion angled downward toward a high-powered electronic device under testing. The probe head has a proximal end comprising an oblique truncated cone portion angled relative to the longitudinal axis at an input angle and has an analog signal input. The probe head has a digital signal output provided on the distal end of the housing.

Abstract: A plate processing line and methods for producing a flexographic printing plate. An imaging station applies image information to a first plate. A first exposure station cures the first plate. One or more of water, a solvent, and/or a thermal process is further applied to the first plate. A drying station or an after-exposure station is configured to expose the plate to further radiation. A feeding station is configured to feed the first plate cured by the exposure station and a second plate cured by a second exposure station to the processing station. A transportation cart may transport the plate between the first or second exposure stations and the processing station.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: The present invention generally relates to pH-dependent mutant interleukin-2 polypeptides that exhibit reduced IL-2 receptor binding at neutral pH and retained IL-2 receptor binding at reduced pH. In addition, the invention relates to immunoconjugates comprising said pH-dependent mutant IL-2 polypeptides, polynucleotide molecules encoding the pH-dependent mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the pH-dependent mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: Provided is a package made of a composite material is represented and described, including a package base with two front base corners and with two rear base corners, a package gable with two front gable corners and with two rear gable corners, and a package base body with a front panel, a first side panel, a second side panel and a rear panel. The package base and the package gable are arranged on opposite sides of the package base body. The composite material has a polymer inner layer, a polymer outer layer and a fibrous support layer, which is arranged between the polymer outer layer and the polymer inner layer. In order to enable the manufacture of packages with even more complex geometries without impairing the rigidity of the package, it is proposed to provide a third sleeve fold line, which has a plurality of sections, which each adjoin a side panel and the rear panel, and of which at least one section is curved.

Abstract: For an arc welding torch device with a consumable electrode designed as a welding wire, wherein the electrode is provided with a direction of movement from a rear end of the arc welding torch device to a feeder in the direction of a front end of the arc welding torch device, in the region of which the electrode melts during an arc welding process, wherein the electrode in the arc welding torch device is guided in an exchangeable wire core, wherein the wire core is itself arranged at least in the region of the rear end of the arc welding torch in a guide element which surrounds the wire core and which is designed as an exchangeable wear part, wherein the guide element of the wire core is provided for to be exchanged together with the wire core as the result of wear, to achieve a movement of the welding wire in the region the process end, with as little resistance as possible, and with the least possible risk that the welding wire buckles due to the feed movement, a single-piece design is proposed for the guide

Abstract: In the case of an arc welding torch device with a consumable electrode. The electrode in the arc welding torch device being guided in an exchangeable wire core, a guide element surrounding the wire core and designed as an exchangeable wear part. To reduce the risk of kinking of a welding wire of an arc welding torch device melting in the welding process, a kink protection means protruding from the arc welding torch device is passed through an outer end cap of the arc welding torch and arranged between the outer end cap of the arc welding torch and wire feeding means for the welding wire in which the welding wire is guided is proposed.

Abstract: In the case an arc welding torch device, having a consumable electrode. The electrode in the arc welding torch device is guided in an exchangeable wire core, the wire core being arranged at least in the region of the rear end of the arc welding torch device in a guide element surrounding the wire core and designed as an exchangeable wear part, and the guide element of the wire core being provided for the joint exchange of the wire core due to wear. It is proposed that a predetermined end position in the arc welding torch device is provided for the guide element with respect to its insertion direction into the arc welding torch device, and when the end position is attained by the guide element, a position signaling means is perceptible outside the arc welding torch device.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: Systems and processes for making a flexo plate, and plates made thereby. Non-printing indicia defined by areas of presence and absence of polymer in the plate floor are readable downstream of the washing or other non-cured-polymer-removal step but do not print in the printing step. The non-printing indicia may define a repeating pattern of alphanumeric characters, non-text graphics, or a combination thereof.

Abstract: A finished flexo plate with printing dots and non-printing indicia. The printing dots have an elevation above the plate floor sufficient to transfer ink to a substrate in a printing step, whereas the non-printing indicia are configured for persistent readability relative to the plate floor but have a height relative to the plate floor insufficient to transfer ink to the substrate in the printing step. The non-printing indicia define a pattern of alphanumeric characters, non-text graphics, or a combination thereof, and are disposed on the plate floor in the form of areas of presence and absence of polymer defined by structures formed of microdots, each microdot having an elevation relative to the plate floor lower than a printing height.

Abstract: The invention relates to the treatment or prevention of renal impairment and/or complications using a SGLT-2 inhibitor, for example in patients diagnosed with metabolic disorders and related conditions.

Abstract: A printing plate having a printing surface for receiving ink, including a defined area of an image intended to print with ink and a surface pattern applied to the defined area. The surface pattern includes a plurality of rows each having a plurality of diagonally oriented line segments, each line segment corresponding to an ink-carrying relief structure in a raised area of the plate, the plurality of diagonally oriented line segments having orientations alternating between a positive angle in one row and a negative angle in an adjacent row, wherein each line segment has a first end aligned with a middle portion of and spaced apart from a first line of a first adjacent row and a second end aligned with a middle portion of and spaced apart from a second line of a second adjacent row.

Abstract: A virtual compute instance that is communicatively coupled to a storage device comprising a database. In an embodiment, a method queries an expense pre-approval application to obtain a set of expense documents from a first computer associated with a first account that is digitally linked to a credit line account and receives the set of expense documents. The expense pre-approval application may be one of a plurality of federated applications hosted using a multi-tenant distributed computing system that comprises the virtual compute instance. The method determines expense data comprising a type of expense document, time of spend, kind of expense, and a plurality of expense charges, for each document in the set of expense documents. Based on the type of document of each expense document in the set of expense documents, the method identifies a payment gateway among a plurality of payment gateways. Each payment gateway executes a plurality of programmatic payment rails that the first account can access.

Abstract: A pedestrian protection feature for a closure latch assembly and method for moving a hood of a motor vehicle to a pop-up position and an open position are provided. The pedestrian protection feature includes an actuator configured to translate a slide cam member to cause a hook to pivot into a striker retaining position to prevent removal of a striker from the closure latch assembly and to pivot a lift lever into engagement with the striker to move the striker toward the hook, whereat the hood is moved to the pop-up position, and optionally a release feature to move the hook from the striker retaining position to a striker releasing position to allow the hood to be moved from the pop-up position to an open position.