Abstract: Provided herein are systems, methods, and compositions for bioluminescence-triggered photocatalytic activation of molecular entities in a proximity-dependent manner, which can be actuated within biological systems. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts, and activatable molecular entities incorporating light-responsive moieties that restrict their activity; systems thereof; and methods for catalytically activating the activatable molecular entities via bioluminescence-triggered catalysis.

Abstract: A flat-shaped composite material is represented and described for manufacturing a package, including: a polymer outer layer, a polymer inner layer, a fibrous support layer, which is arranged between the polymer outer layer and the polymer inner layer. The flat-shaped composite material has a plurality of fold lines, which are arranged and designed such that a closed package can be manufactured by folding the flat-shaped composite material along the fold lines and by connecting seam surfaces of the flat-shaped composite material and a sleeve surface. The sleeve surface includes a front surface, a first side surface, a second side surface, a first rear surface, a second rear surface, and base surfaces. The base surfaces include triangular base surfaces, quadrangular base surfaces, and gable surfaces. The gable surfaces include triangular gable surfaces and quadrangular gable surfaces. The base surfaces and the gable surfaces are arranged on opposite sides of the sleeve surface.

Abstract: The present invention relates to bispecific agonistic CD28 antigen binding molecules characterized by monovalent binding to CD28 comprising new humanized EpCAM antibodies, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.

Abstract: A system and method for assisting selective hearing includes a detector for detecting an audio source signal portion of one or more audio sources by using at least two received microphone signals of a hearing environment. A position determiner allocates position information to each of the one or more audio sources. An audio type classifier assigns an audio source signal type to the audio source signal portion of each of the one or more audio sources. A signal portion modifier varies the audio source signal portion of at least one audio source of the one or more audio sources depending on the audio signal type of the audio source signal portion of the at least one audio source so as to obtain a modified audio signal portion of the at least one audio source. The system includes a signal generator.

Abstract: A package made of a composite material is represented and described, including: a package base with two front base corners and with two rear base corners, a package gable with two front gable corners and with two rear gable corners, and a package base body with a front panel, a first side panel, a second side panel and a rear panel. The package base and the package gable are arranged on opposite sides of the package base body. The composite material has a polymer inner layer, a polymer outer layer and a fibrous support layer, which is arranged between the polymer outer layer and the polymer inner layer. In order to enable the manufacture of packages with even more complex geometries without impairing the rigidity of the package, it is proposed that the package base body has at least one stress-relief panel, which is arranged between the front panel and one of the two side panels.

Abstract: Systems, apparatus, articles of manufacture, and methods to reduce stress between sockets and associated integrated circuit packages having glass cores are disclosed. An example integrated circuit package includes: a semiconductor die, and a substrate including a glass core. The substrate includes a first surface, a second surface opposite the first surface, and a third surface between the first surface and the second surfaces. The first surface supports the semiconductor die. The second surface includes first contacts to electrical couple with second contacts in a socket. At least a portion of the third surface separated and distinct from the glass core.

Abstract: The invention relates to a road construction machine, in particular a road paver or a tandem roller, for working a ground in a forward direction with an operating device which can be displaced and swiveled.

Abstract: A locking device for a vehicle door, in particular for a motor-vehicle bonnet, comprising a first inhibiting pawl prestressed into an inhibiting position, wherein a rotary latch can be arrested in a locking position by the first inhibiting pawl located in its inhibiting position, and a second inhibiting pawl prestressed into an inhibiting position, wherein the rotary latch can be arrested in a safety-catch position by the second inhibiting pawl located in its inhibiting position. The first and second inhibiting pawls can be transferred from their respective inhibiting position into a release position by a common actuating means.

Abstract: Embodiments disclosed herein include sockets and electronic packages with socket architectures. In an embodiment, a socket comprises a housing with a first surface and a second surface. In an embodiment, a plurality of interconnect pins pass through the housing. In an embodiment, an alignment hole is provided through the housing. In an embodiment, an alignment post extending out from the first surface of the housing is also provided.

Abstract: The invention relates to a sensor system (200, 300, 400) for a motor vehicle, comprising a sensor housing and an active or passive sensor (102) arranged therein and held on a movable sensor holder (201, 401), having a sensor technology based on radiation detection and a measurement apparatus assigned to the sensor (102) and a control apparatus, coupled to said measurement apparatus, for the sensor holder (201, 401), wherein the sensor housing has a cover (106, 301) that is signal-transmissive for the sensor (102) on its side located in the detection direction of the sensor (102), and wherein the detection range (108, 109) of the sensor (102) in the region of the signal-transmissive cover (106, 301) has a lower extent than the signal-transmissive cover (106, 301), wherein the sensor system (200, 300, 400) is characterized in that the measurement apparatus is designed such that it is suitable for checking, in the detection range of the sensor (102), whether and in which section the signal-transmissive cover (10

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia.

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions which can be affected by potassium channel modulation. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

Abstract: The present invention relates to a Bacillus host cell for increased production of biological compounds. Specifically, the invention relates to a Bacillus host with genetic modifications that lead to decreased production of components of biofilm and increased levels of phosphorylated De-gll. Said Bacillus host comprises at least one gene expression cassette with a polynucleotide encoding at least one polypeptide of interest, operably linked to a promoter for the production of compounds. The present invention further relates to a method for increased production of at least one polypeptide of interest based on cultivating the bacterial host cell of the present invention.

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: A system and a corresponding method for assisting selective hearing are provided. The system includes a detector for detecting an audio source signal portion of one or more audio sources by using at least two received microphone signals of a hearing environment. In addition, the system includes a position determiner for allocating position information to each of the one or more audio sources. In addition, the system includes an audio type classifier for assigning an audio source signal type to the audio source signal portion of each of the one or more audio sources. In addition, the system includes a signal portion modifier for varying the audio source signal portion of at least one audio source of the one or more audio sources depending on the audio signal type of the audio source signal portion of the at least one audio source so as to obtain a modified audio signal portion of the at least one audio source. In addition, the system includes a signal generator.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: The present invention relates to Her2-targeted bispecific agonistic CD28 antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.

Abstract: The invention relates to a method for introducing a boring channel in the ground by means of an earth boring device, wherein the earth boring device has a boring head which is moved to introduce the boring channel in the ground, and the method comprises the steps: a) detecting obstacles in front of and/or next to the boring head; b) displaying the position of a detected obstacle relative to the boring head; c) issuing a shutdown warning if the distance between the detected obstacle and the boring head is less than a first, in particular selectable, distance; d) stopping boring of the boring channel when a shutdown warning is issued; e) verifying an acknowledgment for continued introduction of the boring channel when a shutdown warning has been issued and boring stopped; and f) continuing the introduction of the boring channel upon successful verification of the acknowledgment.

Abstract: A welding power cable includes at least one welding power source, a welding torch, and a workpiece. The welding power cable is provided with an outer casing for protecting and insulating an electrically conductive cable, wherein the electrically conductive cable is situated within the casing. The end face of the welding power cable is provided with an electrically conductive contacting means for establishing an electrically conductive contact with the welding power source in particular, and a connection means for establishing a detachable mechanical connection, in particular between the welding power source and the welding power cable. This provides an option for connecting and disconnecting such a welding power cable to/from a welding power source in a quick and reliable manner while keeping the torsional stress on the welding power cable in the area of the connection to the welding power source.

Abstract: An optoelectronic device comprises a plurality of optoelectronic light sources being arranged on a first layer, in particular an intermediate layer being arranged between a cover layer and a carrier layer. The first layer comprises or consists of an at least partially transparent material and each optoelectronic light source of the plurality of optoelectronic light sources comprises an individual light converter for converting light emitted by the associated light source into converted light. The light converter of each optoelectronic light source is arranged on the first layer and/or the associated optoelectronic light source.