Patents by Inventor Thomas Klein

Thomas Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10323098
    Abstract: The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ?-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 18, 2019
    Assignee: ROCHE GLYCART AG
    Inventors: Oliver Ast, Peter Bruenker, Anne Freimoser-Grundschober, Sylvia Herter, Thomas U. Hofer, Ralf Hosse, Christian Klein, Ekkehard Moessner, Valeria G. Nicolini, Pablo Umana
  • Publication number: 20190177413
    Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 13, 2019
    Inventors: Marina BACAC, Thomas HOFER, Ralf HOSSE, Christiane JAEGER, Christian KLEIN, Ekkehard MOESSNER, Pablo UMANA, Tina WEINZIERL
  • Patent number: 10316104
    Abstract: The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 11, 2019
    Assignee: ROCHE GLYCART AG
    Inventors: Oliver Ast, Peter Bruenker, Thomas U. Hofer, Ralf Hosse, Christian Klein, Ekkehard Moessner, Pablo Umana
  • Patent number: 10309065
    Abstract: The present invention relates to a rubber tire roller for ground compaction, comprising a machine frame and an operating platform and front and rear undercarriages supporting the machine frame, wherein the undercarriages each comprise at least one wheel. A fundamental idea of the present invention lies in viewing indentations that are open to the side.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: June 4, 2019
    Assignee: BOMAG GmbH
    Inventors: Christian Berg, Ernst-Josef Einolf, Thomas Haubrich, Thomas Klein, Tobias Schonberg
  • Publication number: 20190145135
    Abstract: A closure latch assembly for a decklid configured to provide a power release operation and a power cinch operation. The power cinch operation is a dual-stage cinch operation having a first non-driven cinching stage and a second driven cinching stage. The first cinching stage utilizes the weight of the decklid to drive the decklid from a pop-up position to a cinched position. The second cinching stage utilizes a cinch mechanism to drive the decklid from its cinched position into a fully-closed position.
    Type: Application
    Filed: November 12, 2018
    Publication date: May 16, 2019
    Inventors: Vladmir LEBSAK, Jörg Thomas KLEIN, Henrik JOHANN
  • Publication number: 20190099427
    Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 4, 2019
    Inventors: Thomas KLEIN, Maximilian von EYNATTEN, Michael MARK
  • Patent number: 10195203
    Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: February 5, 2019
    Assignee: Boehringr Ingelheim International GmbH
    Inventors: Thomas Klein, Maximilian von Eynatten, Michael Mark
  • Publication number: 20180371773
    Abstract: A support is provided, comprising a first bar with a first abutment element, a second bar with a second abutment element, and a guiding device by which the first bar is displaceably guided on the second bar. An actuating device which acts on the first bar and which comprises an actuating element is arranged on the second bar. A displacement of the first bar in a first direction of displacement can be initiated by actuation of the actuating element. The first direction of displacement is a direction of increase in distance between the first abutment element and the second abutment element. The actuating device comprises a blocking device which blocks a displacement of the first bar in relation to the second bar in a second direction of displacement, which is opposite the first direction of displacement, at least when no active releasing action occurs at the blocking device.
    Type: Application
    Filed: June 6, 2018
    Publication date: December 27, 2018
    Inventors: Thomas Klein, Gerhard Kloepfer
  • Publication number: 20180362724
    Abstract: The present invention provides a novel process for producing rubber-modified bitumen using vulcanized rubber.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 20, 2018
    Applicant: LANXESS Deutschland GmbH
    Inventors: Thomas KLEIN, Torsten ZISER
  • Publication number: 20180263990
    Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.
    Type: Application
    Filed: May 22, 2018
    Publication date: September 20, 2018
    Inventors: Odd-Erik JOHANSEN, Maximilian VON EYNATTEN, Thomas KLEIN, Hans-Juergen WOERLE
  • Publication number: 20180223486
    Abstract: The present invention relates to a road paver for paving paving material in a paving direction (a), comprising a machine frame, a driver's platform, a drive motor, a chassis with at least a left travel unit and a right travel unit, a material container arranged at the front of the road paver in the paving direction (a) for receiving paving material, the material container comprising a left container half and a right container half, which each have a container floor, a rising container sidewall and a rising container rear wall, and a longitudinal conveying device configured to transport paving material from the material container to a paving screed arranged at the rear of the road paver in the paving direction, wherein the container halves can be moved out of a filling position in order to move the paving material onto the longitudinal conveying device, wherein at least one container half has a viewing indentation, which extends from the container rear wall to the container floor in such a way that the ground
    Type: Application
    Filed: February 2, 2018
    Publication date: August 9, 2018
    Inventors: Thorsten Anheier, Thomas Haubrich, Thomas Klein
  • Publication number: 20180214468
    Abstract: The invention relates to the treatment or prevention of renal impairment and/or complications using a SGLT-2 inhibitor, for example in patients diagnosed with metabolic disorders and related conditions.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 2, 2018
    Inventors: Uli Christian BROEDL, Maximilian von EYNATTEN, Odd-Erik JOHANSEN, Thomas KLEIN, Gerd Roland LUIPPOLD
  • Publication number: 20180193427
    Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 12, 2018
    Inventors: Rolf GREMPLER, Odd-Erik JOHANSEN, Thomas KLEIN, Gerd LUIPPOLD, Michael MARK
  • Publication number: 20180187383
    Abstract: The invention relates to a height-adjustable operating platform of a compact paver comprising a machine frame, a drive motor, travel units, a receiving container at the front in relation to the paving direction for receiving paving material, a longitudinal conveying device with which the paving material can be conveyed from the receiving container in a rearward direction in relation to the paving direction, a transverse distribution device that is height-adjustable in relation to the machine frame and with which the paving material can be distributed on the ground surface transversally to the paving direction, a paving screed that is height-adjustable in relation to the machine frame for compacting and smoothing the paving material distributed on the ground surface behind the transverse distribution device in the paving direction, an operating platform mounted on the machine frame and arranged behind the receiving container in the paving direction and a method for operating a compact paver.
    Type: Application
    Filed: January 2, 2018
    Publication date: July 5, 2018
    Inventors: Thorsten ANHEIER, Thomas HAUBRICH, Thomas KLEIN, Andreas ROESCH
  • Publication number: 20180187382
    Abstract: The invention relates to a compact paver comprising a machine frame, a drive motor, travel units, a receiving container at the front in relation to the paving direction for receiving paving material, a longitudinal conveying device with which the paving material can be conveyed from the receiving container in a rearward direction in relation to the paving direction, a transverse distribution device with which the paving material can be distributed on the ground surface transversally to the paving direction, a paving screed that is height-adjustable in relation to the machine frame for compacting and smoothing the paving material distributed on the ground surface behind the transverse distribution device in the paving direction, and an operating platform mounted on the machine frame and arranged behind the receiving container in the paving direction.
    Type: Application
    Filed: January 2, 2018
    Publication date: July 5, 2018
    Inventors: Thorsten ANHEIER, Thomas HAUBRICH, Thomas KLEIN, Andreas ROESCH
  • Patent number: 10004747
    Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: June 26, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Klein, Rolf Grempler, Michael Mark
  • Patent number: D819704
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: June 5, 2018
    Assignee: BOMAG GmbH
    Inventors: Roland Loew, Stephan Jakobs, Thomas Haubrich, Thomas Klein
  • Patent number: D826133
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: August 21, 2018
    Assignee: BOMAG GmbH
    Inventors: Roland Loew, Christian Berg, Thomas Klein, Tobias Schönberg
  • Patent number: D833041
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: November 6, 2018
    Assignee: BOMAG GmbH
    Inventors: Roland Loew, Christian Berg, Thomas Klein, Tobias Schönberg
  • Patent number: D846456
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: April 23, 2019
    Assignee: BOMAG GmbH
    Inventors: Roland Loew, Christian Berg, Thomas Klein, Tobias Schönberg