Abstract: The present invention relates to Her2-targeted bispecific agonistic CD28 antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: A holding stand for a support is provided, comprising a put up-receiving device for the support which has a support put up face, and at least three stand legs. Each of the stand legs has a first arm and a second arm which are connected to one another. The second arm is oriented at an acute angle to the first arm. The put up-receiving device is arranged on the first arms of the stand legs. In a holding state of the holding stand, the stand legs define a stand leg put up plane for the holding stand. A floor side of the put up-receiving device facing away from the support put up face lies in the put up plane, at least when a force loading of the put up-receiving device exceeds a specific threshold value or threshold value range in the direction of the put up plane.

Abstract: A welding current source for supplying an arc welding torch with electric current and electric voltage for carrying out an arc welding method, wherein the arc welding current source is provided with a housing in which a current transformer device is provided for processing electric current and voltage fed into the welding current source for suitability in an arc welding method, wherein furthermore two pole contact devices are provided on the housing of the welding current source, each of which protrudes out of the housing along a respective longitudinal axis and is provided with connecting means for receiving a welding current cable. The aim is to provide a possibility that collisions with welding current cables connected to a welding current source of the aforementioned type can be prevented as much as possible.

Abstract: Apparatus and method for exposing a partially processed photopolymer printing plate to post-exposure radiation and finishing radiation, the printing plate defining a whole area having a first full lateral dimension and a second full lateral dimension perpendicular to the first lateral dimension. A plurality of light-emitting diodes (LEDs) are arranged in one or more arrays; a surface for receiving the printing plate in a location disposed to receive the post exposure radiation and the finishing radiation; and one of more controllers connected to the one or more arrays to activate the one or more arrays to cause the plurality of sets of LEDs to emit radiation toward the printing plate. The plurality of LEDs includes at least a first set of LEDs to emit the post exposure radiation in a UVA spectral range and a second set of LEDs to emit the finishing radiation in a UVC spectral range.

Abstract: The invention relates to a road construction machine, in particular a road paver or a tandem roller, for working a ground in a forward direction with an operating device which can be displaced and swiveled.

Abstract: A locking device for a vehicle door, in particular for a motor-vehicle bonnet, comprising a first inhibiting pawl prestressed into an inhibiting position, wherein a rotary latch can be arrested in a locking position by the first inhibiting pawl located in its inhibiting position, and a second inhibiting pawl prestressed into an inhibiting position, wherein the rotary latch can be arrested in a safety-catch position by the second inhibiting pawl located in its inhibiting position. The first and second inhibiting pawls can be transferred from their respective inhibiting position into a release position by a common actuating means.

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia.

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: A welding power cable includes at least one welding power source, a welding torch, and a workpiece. The welding power cable is provided with an outer casing for protecting and insulating an electrically conductive cable, wherein the electrically conductive cable is situated within the casing. The end face of the welding power cable is provided with an electrically conductive contacting means for establishing an electrically conductive contact with the welding power source in particular, and a connection means for establishing a detachable mechanical connection, in particular between the welding power source and the welding power cable. This provides an option for connecting and disconnecting such a welding power cable to/from a welding power source in a quick and reliable manner while keeping the torsional stress on the welding power cable in the area of the connection to the welding power source.

Abstract: An operating device of a welding system is provided with a display means for visually displaying set parameter values of the welding system, and comprises input means by which parameters of the welding system can be changed. An operating device includes a plurality of input means arranged outside the display means, is provided. The input means is designed as soft keys, wherein, each of the soft keys can be assigned parameters of the arc welding method or functions, via operation of the operating device, due to the fact that the display means is designed as a touch-sensitive touchscreen and the respective soft key can be assigned a specific parameter or a specific function by selection from a predefined selection of parameters or functions displayed on the display means and, after selection, the respective parameter can be changed or the function can be applied by actuating the respective soft key.

Abstract: The invention relates to a construction machine (1) with a machine frame (2), a driver cab (6) with a right and a left door-window unit (12) when viewed in a traveling direction (A) of the construction machine (1), wherein the door-window units (12) are adjustable between a closed and an open position, and with a drive engine (13) and front and rear traveling devices (4, 5). Essentially, the door-window units (12) can be opened in an opposite manner, in particular depending on the side of the machine frame (2) on which the front and rear traveling devices (4, 5) respectively sit flush with the machine frame (2). The invention is particularly relevant for ground compaction machines, in particular rubber-tired rollers. The invention further relates to a method for operating a construction machine (1) and a method for manufacturing a construction machine (1).

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: A clamp, comprising a guide rail, a fixed jaw, which is arranged on the guide rail, a sliding jaw, which is displaceable on the guide rail, and at least one spindle, which is arranged displaceably on the sliding jaw and on which there is arranged or formed a pressure piece, with an actuation device, which is spaced from the at least one spindle and which actuable by an operator in order to control a displacement movement of the at least one spindle, with a force application device, which acts on the at least one spindle and by means of which a displacement movement of the at least one spindle is achievable, and with a transmission device, which connects the actuation device and the force application device.

Abstract: A soil processing machine, in particular a soil compactor, includes at least one drive roller and an electrohydraulic drive system for driving at least one drive roller. The drive system has a traction hydraulic circuit having at least one hydraulic motor and at least one hydraulic pump. The circuit includes a first line region between a first connection fitting of the at least one hydraulic pump and a first connection fitting of each hydraulic motor to drive the at least one drive roller in a first rotatable direction and a second line region between a second connection fitting of the at least one hydraulic pump and a second connection fitting of each hydraulic motor to drive the at least one drive roller in a second, opposite rotatable direction. A valve assembly is provided with each line region for selectively interrupting and releasing a fluid flow connection between the at least one hydraulic pump and at least one hydraulic motor.

Abstract: A soil processing machine includes a hydraulic drive system including an electrohydraulic pressurized fluid source with at least one electric motor and at least one hydraulic drive pump, a hydraulic drive circuit fed with pressurized fluid by the at least one hydraulic drive pump, at least one hydraulic drive motor fed with pressurized fluid from the hydraulic drive circuit, and a discharge valve assembly for discharging fluid from the hydraulic drive circuit to a fluid reservoir. The hydraulic drive system is designed to operate the discharge valve assembly as a function of at least one of the following parameters: a temperature of the fluid in the hydraulic drive circuit, an ambient temperature, a viscosity of the fluid in the hydraulic drive circuit, a degree of contamination of the fluid in the hydraulic drive circuit, a period of time since the last start-up of the hydraulic drive system, a period of time since the last fluid was discharged from the hydraulic drive circuit.

Abstract: A construction machine, in particular a road paver or tandem roller, for working a ground in a working direction, having a machine frame, an operator platform with at least one operator platform door and at least one travel unit, and an operating unit, the operating unit comprising an operator's seat for an operator of the construction machine, an operating console with operating elements for controlling the construction machine by the operator, a support structure on which both the operator's seat and the operating console are arranged, and a transverse guide with at least one guide rail, wherein the support structure is movably mounted on the at least one guide rail, so that the support structure together with the operator's seat and the operating console are configured to be movable along the at least one guide rail, wherein the support structure is configured such that it can be swiveled together with the operator's seat and the operating console about a swivel axis running in particular in vertical direc

Abstract: A plate processing line and methods for producing a flexographic printing plate. An imaging station applies image information to a first plate. A first exposure station cures the first plate. One or more of water, a solvent, and/or a thermal process is further applied to the first plate. A drying station or an after-exposure station is configured to expose the plate to further radiation. A feeding station is configured to feed the first plate cured by the exposure station and a second plate cured by a second exposure station to the processing station. A transportation cart may transport the plate between the first or second exposure stations and the processing station.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.