Abstract: A method of creating a bitmap for a printing plate, including defining an area of an image intended to print with a solid color, applying a halftone screen to the defined solid color area, and creating the bitmap embodying the halftone screen in the defined solid color area. The halftone screen pattern includes a plurality of dashes with a plus or minus 45-degree orientation, a plus or minus 135-degree orientation, or a combination of two or more plus or minus 45-degree and 135-degree orientations. Each dash or component dash thereof has a same number of two or more adjacent touching pixels in length and a number of one or more adjacent touching pixels in width, or the dashes are orthogonally arranged in rows and columns, or a combination thereof. Masks, plates, processes for making them, and print methods using the bitmaps are also described.

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and an insulin which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia.

Abstract: The invention relates to the treatment or prevention of renal impairment and/or complications using a SGLT-2 inhibitor, for example in patients diagnosed with metabolic disorders and related conditions.

Abstract: Apparatus and method for exposing a printing plate having a photosensitive polymer to curing radiation. A plurality of light-emitting diodes (LEDs) are arranged in an array of columns and rows, including at least two, and more preferably at least three, different species, each species having a different center emission wavelength, preferably in the UV spectrum. The LEDs species are disposed adjacent one another in a repeating sequence. A controller connected to the array is configured to activate the array and to independently control each of the species to cause them to emit radiation towards the printing plate simultaneously with emissions patterns of adjacent members overlapping one another on the plate. A linear or planar source may comprise a plurality of independently controllable arrays.

Abstract: A method of creating a bitmap for a printing plate, including defining an area of an image intended to print with a solid color, applying a halftone screen to the defined solid color area, and creating the bitmap embodying the halftone screen in the defined solid color area. The halftone screen pattern includes a plurality of dashes with a plus or minus 45-degree orientation, a plus or minus 135-degree orientation, or a combination of two or more plus or minus 45-degree and 135-degree orientations. Each dash or component dash thereof has a same number of two or more adjacent touching pixels in length and a number of one or more adjacent touching pixels in width, or the dashes are orthogonally arranged in rows and columns, or a combination thereof. Masks, plates, processes for making them, and print methods using the bitmaps are also described.

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: A separating device for a gravity conveyor, comprising: a) a conveying plane (E) which is defined by at least two guides (20), in particular sliding guides or conveying rollers, for conveying an item (30) to be conveyed and along which the item (30) to be conveyed can be moved in a conveying direction (F); b) at least one separating stop (40) which can be moved between a position above the conveying plane (E) and a position below or flush with the conveying plane (E); c) an actuating means (50) which, in order to actuate it, comprises a first actuating member (51) and a second actuating member (52) and which is coupled to the at least one separating stop (40) in such a way that, when the actuating means (50) is actuated, a movement of the at least one separating stop (40) from the position above the conveying plane (E) to the position below or flush with the conveying plane (E) is blocked, and when the actuating means (50) is unactuated, a movement of the at least one separating stop (40) from the position

Abstract: A device and a method for providing granular matter is described. The device includes a receiving container configured and adjusted for receiving the granular matter. The receiving container has an output for providing the granular matter to a further processing. The device has a measuring unit configured for measuring a density of the granular matter in the receiving container using terahertz spectroscopy.

Abstract: A system and a method for a constant micro dosing of powder material include a control device, a cylinder with a first opening and a piston movably arranged inside the cylinder and controllable by the control device. The piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder stores the powder material between the piston and the first opening. The piston pushes the powder material through the first opening by moving along the piston stroke direction. Further the system and the method include a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device controls the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.

Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.

Abstract: A locking device for a vehicle door, in particular for a motor-vehicle bonnet, comprising a first inhibiting pawl prestressed into an inhibiting position, wherein a rotary latch can be arrested in a locking position by the first inhibiting pawl located in its inhibiting position, and a second inhibiting pawl prestressed into an inhibiting position, wherein the rotary latch can be arrested in a safety-catch position by the second inhibiting pawl located in its inhibiting position. The first and second inhibiting pawls can be transferred from their respective inhibiting position into a release position by a common actuating means.

Abstract: The invention relates to a pharmaceutical combination according to the invention comprising an SSAO/VAP-1 inhibitor according to the formula (I) wherein R1 to R6, and X are as defined herein, and an SGLT2 inhibitor. In addition the present invention relates to methods for preventing, slowing the progression of, delaying or treating fibrotic disorders, metabolic disorders, inflammation disorders, ocular diseases, neuroinflammatory disorders or cancer in a patient in need thereof characterized in that the pharmaceutical combination according to the invention is administered to the patient.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: A locking device for a vehicle door, in particular for a motor-vehicle bonnet, comprising a first inhibiting pawl prestressed into an inhibiting position, wherein a rotary latch can be arrested in a locking position by the first inhibiting pawl located in its inhibiting position, and a second inhibiting pawl prestressed into an inhibiting position, wherein the rotary latch can be arrested in a safety-catch position by the second inhibiting pawl located in its inhibiting position. The first and second inhibiting pawls can be transferred from their respective inhibiting position into a release position by a common actuating means.

Abstract: Disclosed are a system and a computer implemented method for use in the course of a clinical trial and/or precision medicine, wherein patient metrics are acquired and the system comprises selected core modules, methods and/or automated services and selected empowerment apps.

Abstract: The invention relates to a construction machine (1) with a machine frame (2), a driver cab (6) with a right and a left door-window unit (12) when viewed in a traveling direction (A) of the construction machine (1), wherein the door-window units (12) are adjustable between a closed and an open position, and with a drive engine (13) and front and rear traveling devices (4, 5). Essentially, the door-window units (12) can be opened in an opposite manner, in particular depending on the side of the machine frame (2) on which the front and rear traveling devices (4, 5) respectively sit flush with the machine frame (2). The invention is particularly relevant for ground compaction machines, in particular rubber-tired rollers. The invention further relates to a method for operating a construction machine (1) and a method for manufacturing a construction machine (1).

Abstract: The present invention relates to a construction machine, said construction machine comprising a brake assembly for braking the machine, as well as an operator platform. The operator platform comprises at least one operator seat with a total of at least two operating positions for a machine operator at opposite ends of the operator platform, and an actuation device for foot actuation of the brake assembly. According to essential aspects of the present invention, the actuation device for the brake assembly comprises a brake beam which extends transversely to the working direction of the construction machine and which can be operated by foot from said two operating positions, and the actuation device further comprises an actuator for the brake beam, which is arranged below the brake beam.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: The invention relates to a pharmaceutical combination according to the invention comprising an AOC3 inhibitor according to the formula (I) wherein R1 and A are as defined herein, and an SGLT2 inhibitor. In addition the present invention relates to methods for preventing, slowing the progression of, delaying or treating fibrotic disorders, metabolic disorders, inflammation disorders, ocular diseases, neuroinflammatory disorders or cancer in a patient in need thereof characterized in that the pharmaceutical combination according to the invention is administered to the patient.