Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Abstract: The present invention relates to novel prodrugs of primary or secondary amine- or hydroxyl-comprising biologically active moieties and pharmaceutically acceptable salts thereof, prodrug reagents, pharmaceutical compositions comprising these prodrugs and the use of these prodrugs. A disclosed prodrug may include a biologically active moiety reversibly and covalently linked to a specialized protective group; the linker may be reversible (i.e., hydrolytically cleavable in the absence of enzymes under physiological conditions) and, upon cleavage, may release a drug in its unmodified, pharmacologically active form.

Abstract: A method of virtual wrapping wherein the overall human experience is significantly enhanced with key human-centric innovations providing significant improvements in convenience, uniqueness, and meaningfulness.

Abstract: A transport system for transporting and/or positioning objects along a transport section, wherein the transport system includes at least one rotatable transport body having at least one curved transport path which is delimited by at least one curve flank pair and, as seen in the linear transport direction, has at least one positive curved transport path pitch throughout and into which there can engage or there engages at least one pusher dog of a carrier that is movable along the transport section, wherein the at least one transport body has at least one entry region for the entry of the at least one pusher dog into the curved transport path.

Abstract: A transport system for transporting and/or positioning objects along a transport section, wherein the transport system includes at least one rotatable transport body having at least one curved transport path which is delimited by at least one curve flank pair and, as seen in the linear transport direction, has at least one positive curved transport path pitch throughout and into which there can engage or there engages at least one pusher dog of a carrier that is movable along the transport section, wherein the at least one transport body has at least one entry region for the entry of the at least one pusher dog into the curved transport path.

Abstract: The present invention relates to a process for the preparation of a hydrogel-linked prodrug releasing a tag moiety-biologically active moiety conjugate, to a hydrogel-linked prodrug releasing a tag moiety-bio logically active moiety conjugate obtainable by such process, to pharmaceutical compositions comprising said prodrug and their use as a medicament.

Abstract: The present invention relates to IL-2 conjugates, a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such IL-2 conjugate or a pharmaceutically acceptable salt thereof and their uses.

Abstract: The present invention relates to a conjugate comprising a moiety of formula (I) or to conjugates of formula (I?) and to pharmaceutical compositions comprising such conjugates.

Abstract: Knowledge graphing can include: generating a document selection interface that enables a user to browse at least one document storage service and select a set of documents stored on the document storage service for inclusion in a knowledge set; obtaining a set of meta-data for each document selected for the knowledge set from the respective document storage service; and generating a knowledge graph that spatially depicts a set of relationships among the documents of the knowledge set in terms of the meta-data.

Abstract: The present invention relates to a process for the preparation of a hydrogel-linked prodrug releasing a tag moiety-biologically active moiety conjugate, to a hydrogel-linked prodrug releasing a tag moiety-bio logically active moiety conjugate obtainable by such process, to pharmaceutical compositions comprising said prodrug and their use as a medicament.

Abstract: The specification and drawings present methodology for modularly expanding sensing capabilities of a luminaire or a luminaire mounted sensing system by adding replaceable exterior sensor module(s) in a desired position in a vicinity of an existing (legacy) luminaire or a luminaire system for both inside and outside applications. For outside applications, this modular expansion may be performed while maintaining weathertight sealing integrity, e.g., waterproofing of the luminaire-sensor system/apparatus including exterior housing, exterior electrical connections, cables and any other exposed components. The embodiments described herein can provide diverse sensor capability and future expansion needs for luminaire mounted sensing systems and for processing sensor signals.

Abstract: Providing an organized knowledge cloud can include: obtaining a user-selection of a set of documents scattered among a set of disparate document storage services for inclusion in a document integration; determining a set of document integration parameters for each document selected for the document integration; and generating a visual depiction of one or more of the documents included in the document integration in response to the document integration parameters such that the visual depiction enables user access to one or more of the documents included in the visual depiction.

Abstract: The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.

Abstract: The present disclosure relates to the processing of hops. More specifically, an apparatus and method for extracting lupulin from hops are disclosed. Hops are brought into contact with a cooling agent, such as dry ice, to freeze or cool the hops. This cooling is facilitated by mixing the hops and the dry ice together inside of a tumbler. The tumbler continuously rotates to mix the dry ice and hops. Further mixing is afforded by an internal agitator that sweeps the interior of the tumbler. The agitator also pulverizes the hops and separates the hops from the particulate lupulin material. The tumbler is formed from a mesh material that allows the extracted lupulin to leave the tumbler and be collected.

Abstract: A method for processing a measured-value signal representing a value, determined in analog form, for the output current of a converter, and device for carrying out the method, the measured-value signals acquired by a sensor, especially including a shunt resistor, being supplied to a respective processing channel that has at least one delta-sigma modulator.

Abstract: The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Abstract: The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Abstract: A method for processing a measured-value signal representing a value, determined in analog form, for the output current of a converter, and device for carrying out the method, the measured-value signals acquired by a sensor, especially including a shunt resistor, being supplied to a respective processing channel that has at least one delta-sigma modulator.

Abstract: The specification and drawings present methodology for modularly expanding sensing capabilities of a luminaire or a luminaire mounted sensing system by adding replaceable exterior sensor module(s) in a desired position in a vicinity of an existing (legacy) luminaire or a luminaire system for both inside and outside applications. For outside applications, this modular expansion may be performed while maintaining weathertight sealing integrity, e.g., waterproofing of the luminaire-sensor system/apparatus including exterior housing, exterior electrical connections, cables and any other exposed components. The embodiments described herein can provide diverse sensor capability and future expansion needs for luminaire mounted sensing systems and for processing sensor signals.