Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: The invention provides a process for regenerating a catalyst used for the hydrogenation of an aromatic species, consisting of several steps. First the system is purged with nitrogen, then air is metered in stepwise, and the addition of nitrogen is subsequently ended until only air is present.

Abstract: Apparatus, systems, and methods for directing an autonomous robotic vehicle such as a lawn mower relative to a work region. In some embodiments, the vehicle travels in a random pattern within a travelling containment zone of a lesser size than the work region. The travelling containment zone may move or travel across the work region such that, over time, the travelling containment zone travels over most all of a working surface of the work region.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.

Abstract: Apparatus, systems, and methods for directing an autonomous robotic vehicle such as a lawn mower relative to a work region. In some embodiments, the vehicle travels in a random pattern within a travelling containment zone of a lesser size than the work region. The travelling containment zone may move or travel across the work region such that, over time, the travelling containment zone travels over most all of a working surface of the work region.

Abstract: Herein is reported a method for determining non-specific clearance of an antibody comprising the steps of incubating the antibody, which is conjugated to a pH-sensitive fluorescent dye, with primary human endothelial cells, and determining the fluorescence intensity of the primary human endothelial cells, whereby an increase of the fluorescence intensity of the primary human endothelial cells above background level is indicative for non-specific clearance of the antibody.

Abstract: Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: Autonomous machine navigation techniques may generate a three-dimensional point cloud that represents at least a work region based on feature data and matching data. Pose data associated with points of the three-dimensional point cloud may be generated that represents poses of an autonomous machine. A boundary may be determined using the pose data for subsequent navigation of the autonomous machine in the work region. Non-vision-based sensor data may be used to determine a pose. The pose may be updated based on the vision-based pose data. The autonomous machine may be navigated within the boundary of the work region based on the updated pose. The three-dimensional point cloud may be generated based on data captured during a touring phase. Boundaries may be generated based on data captured during a mapping phase.

Abstract: An autonomous machine may be returned to a base station for charging based on remaining battery energy and an estimated travel energy threshold. The estimated travel energy threshold may be determined based on a direct and obstacle-free route from the machine's current position to the base station and an estimated energy consumed per unit distance, which may be updated. The remaining battery energy may be calculated using a battery management system.

Abstract: A supplemental monitoring and security function and system for use with an autonomous working machine such as a robotic lawn mower. The system may use cameras associated with the machine to capture image data and transmit the data to a remote computer. The system may be utilized as a theft deterrent for the mower itself, as well as provide a mobile sentry mode for surveilling and observing a property.

Abstract: Autonomous machine navigation techniques may generate a three-dimensional point cloud that represents at least a work region based on feature data and matching data. Pose data associated with points of the three-dimensional point cloud may be generated that represents poses of an autonomous machine. A boundary may be determined using the pose data for subsequent navigation of the autonomous machine in the work region. Non-vision-based sensor data may be used to determine a pose. The pose may be updated based on the vision-based pose data. The autonomous machine may be navigated within the boundary of the work region based on the updated pose. The three-dimensional point cloud may be generated based on data captured during a touring phase. Boundaries may be generated based on data captured during a mapping phase.

Abstract: This disclosure provides an autonomous machine system having a scheduling controller configured to determine one or more windows of availability over a time period when the autonomous machine is allowed to operate to perform one or more operational tasks; determine a total operation time over the time period; and determine an operating schedule for a work region that assigns one or more operational tasks to the one or more windows of availability based on the total operation time. The autonomous machine may be commanded to operate in the work region according to the operating schedule.

Abstract: Herein is reported a method for providing a modified antibody with improved in vivo half-live, comprising the modification of the Fc-region of the antibody by introducing one or more mutations that change the binding of the Fc-region to human FcRn until the (relative) retention time of the modified antibody in an FcRn affinity chromatography is increased for more than 1 minute but not more than 5 minutes compared to the parent antibody.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: Various embodiments include a method for diagnosis of a high-pressure sensor of a motor vehicle comprising: measuring a pressure with the high-pressure sensor; feeding the measured pressure to a control unit; evaluating the measured pressure with the control unit and determining a control signal for an amount of fuel to be injected; checking whether a first difference between two successive values of the pressure measurement signal is greater than a calculated maximum difference value; checking whether a second difference between a minimum pressure measurement signal measured within a time segment and a maximum pressure measurement signal measured within the time segment is less than an expected change in the pressure measurement signal; and checking whether a measured pressure gradient is smaller than an expected pressure gradient.

Abstract: A handle assembly for an autonomous vehicle such as a lawn mower is provided and may include a cradle adapted to receive a mobile computer. The mobile computer may communicate with a controller carried by the mower. The handle assembly may be configured in both an autonomous mode position and a manual mode position. The vehicle may operate autonomously when the handle assembly is in the autonomous mode position, and be adapted to move under manual operator control, e.g., for perimeter training, when the handle assembly is in the manual mode position. Methods for training the mower and apparatus for storing the mower are also provided.

Abstract: Various embodiments include a method for diagnosis of a high-pressure sensor of a motor vehicle comprising: measuring a pressure with the high-pressure sensor; feeding the measured pressure to a control unit; evaluating the measured pressure with the control unit and determining a control signal for an amount of fuel to be injected; checking whether a first difference between two successive values of the pressure measurement signal is greater than a calculated maximum difference value; checking whether a second difference between a minimum pressure measurement signal measured within a time segment and a maximum pressure measurement signal measured within the time segment is less than an expected change in the pressure measurement signal; and checking whether a measured pressure gradient is smaller than an expected pressure gradient.

Abstract: Apparatus, systems, and methods for directing an autonomous robotic vehicle such as a lawn mower relative to a work region. In some embodiments, the vehicle travels in a random pattern within a travelling containment zone of a lesser size than the work region. The travelling containment zone may move or travel across the work region such that, over time, the travelling containment zone travels over most all of a working surface of the work region.