Abstract: The application includes a description of novel intermediates, of new manufacturing steps resulting in a novel and improved process for producing the intermediates and the final compounds, i.e., 6-alkynyl-pyridine derivatives. The intermediates of the invention are useful to produce 6-alkynyl-pyridine derivatives, which compounds are useful for the treatment of cancer.

Abstract: A metering and mixing device contains a multichamber cartridge and a cartridge holder having a reception container for the multichamber cartridge and a compressed air connection and a connection for an application device. The reception container has an internal tube arranged coaxially to the walls of the cartridge holder and equipped with static mixing elements. The multichamber cartridge contains an upper portion having a directional valve, a middle portion configured as a tubular empty space surrounded by at least two chambers arranged tubularly in the direction of the longitudinal axis of the cartridge, and a lower portion having a piston for each chamber. The multichamber cartridge is arranged in the cartridge holder such that the inner wall of the inner tube of the multichamber cartridge bears, leak-tight, against the outer wall of the tube of the cartridge holder.

Abstract: The application includes a description of novel intermediates, of new manufacturing steps resulting in a novel and improved process for producing the intermediates and the final compounds, i.e., 6-alkynyl-pyridine derivatives. The intermediates of the invention are useful to produce 6-alkynyl-pyridine derivatives, which compounds are useful for the treatment of cancer.

Abstract: A system includes a processor. The processor is configured to identify relevant factors related to a configuration of a power production system comprising a gas turbine system based at least on a fleet data for a fleet of the gas turbine system. The processor is further configured to build one or more risk models configured to derive a probability of achieving a performance level for the configuration based on the relevant factors. The processor is additionally configured to execute the risk models to derive an engineering recommendation, a commercial recommendation, or a combination thereof.

Abstract: A metering and mixing device contains a multichamber cartridge and a cartridge holder having a reception container for the multichamber cartridge and a compressed air connection and a connection for an application device. The reception container has an internal tube arranged coaxially to the walls of the cartridge holder and equipped with static mixing elements. The multichamber cartridge contains an upper portion having a directional valve, a middle portion configured as a tubular empty space surrounded by at least two chambers arranged tubularly in the direction of the longitudinal axis of the cartridge, and a lower portion having a piston for each chamber. The multichamber cartridge is arranged in the cartridge holder such that the inner wall of the inner tube of the multichamber cartridge bears, leak-tight, against the outer wall of the tube of the cartridge holder.

Abstract: A valve includes a housing that surrounds a fluid outlet, a valve element with a longitudinal axis, a valve seat body that surrounds a fluid inlet and which has a sealing seat such that the valve is closed when the valve element bears against the sealing seat and which is coupled to the housing. The valve element is movable relative to the valve seat body in a direction of the longitudinal axis to enable a fluid flow from the fluid inlet to the fluid outlet, the valve seat body surrounds a guide surface to which the valve element is coupled in order to guide the movement of the valve element, and the valve seat body is formed from a harder material than the housing.

Abstract: A solenoid valve includes a housing, a valve actuation device, and a closing element, wherein the housing includes an interior space with a central axis, wherein the valve actuation device includes an actuator arranged in the interior space so as to be displaceable along the central axis, wherein the actuator is operatively connected to the closing element such that the solenoid valve is opened or closed by a displacement of the actuator along the central axis, wherein the actuator together with the housing delimit, in the interior space of the housing, a leakage chamber that can be filled with a fluid, e.g., a fuel, and wherein in the leakage chamber, at least one vortex generator is arranged on the housing and/or on the actuator, which vortex generator is configured to generate a fluid vortex in the leakage chamber.

Abstract: A wind energy installation having a wind rotor, a generator which is driven thereby and interacts with a converter in order to produce electrical power, rotation-speed regulation and converter control which interacts therewith, wherein the rotation-speed regulation outputs a nominal rotation speed signal (nref). Furthermore, additional regulation is provided, which has an input for an additional power and is designed to produce a rotation speed change signal therefrom, taking account of a rotator inertia moment, and to output this as an output signal, which is added to the nominal rotation speed signal via a logic element. Kinetic energy is taken from the wind rotor in a controlled manner by reducing the rotation speed and is converted by the generator to additional electrical energy. This allows primary regulation power to be made available deliberately by rotation speed variation, to be precise even in unsteady wind conditions.

Abstract: The invention relates to a shoe, in particular to a sports shoe, which has a shoe upper part and a sole which is connected to the shoe upper part, wherein the shoe upper part having two tensioning sections which are arranged adjacently in a tensioning region and are separated by a gap, wherein a fastening system is arranged by which the shoe can be fastened to the foot of the wearer of the shoe by a fastening lace as a result of the adjacently arranged tensioning sections being drawn towards one another. In order to improve the tension of the shoe on the foot of the wearer, the fastening system includes, in addition to the fastening lace, at least one tie element which has two ends, and wherein a loop of the at least one tie element formed in the region of the tensioning section being enlaced by the fastening lace.

Abstract: A valve includes a spring with a spring force, an actuator with an actuator force which can act against the spring force, a pin which can be actuated by the actuator, a sealing element which can be coupled with the pin, and a seal seat such that the valve is closed when the sealing element rests against the seal seat. The pin can be moved in the direction of the sealing element by means of the actuator, and the pin can be moved in the direction away from the sealing element by means of the spring. The sealing element can be moved into an open position independently of the pin, wherein a fluid flow through the valve is released in the open position.

Abstract: A shoe having a sole connected with an upper shoe part that has two adjacent arranged tensioning sections in its instep region which are separated by a gap. A lacing system is arranged so the shoe can be laced at the foot of the wearer by pulling the tensioning sections against another. The lacing system has a central closure that tensions a first tensioning element. A tension transmitting element has first and second tensioning parts. The first tensioning element engages into the first tensioning part and pulls the same, during lacing of the first tensioning element, toward the instep region. A second tensioning element has two ends fixed at the sole. The second tensioning element engages into the second tensioning part and pulls the same, during lacing of the first tensioning element, toward the sole. The first and second tensioning parts are connected together via a tensioning element.

Abstract: A wind power plant, including a generator driven by a rotor in order to generate electrical power and a controller that includes a pitch module for adjusting a pitch angle of blades of the rotor. The controller has an input for a required power reserve and determines a target pitch angle depending on an operating point of the wind power plant. A secondary pitch controller is also provided, which includes a detector for available power and a dynamic offset module. Input signals for the available reserve power determined by the detector, the required reserve power and the generated electrical power are applied to the dynamic offset module, which is designed to determine a value for a pitch angle offset. An activation element varies the target pitch angle by the pitch angle offset.

Abstract: A shoe having a sole connected with an upper shoe part that has two adjacent arranged tensioning sections in its instep region which are separated by a gap. A lacing system is arranged so the shoe can be laced at the foot of the wearer by pulling the tensioning sections against another. The lacing system has a central closure that tensions a first tensioning element. A tension transmitting element has first and second tensioning parts. The first tensioning element engages into the first tensioning part and pulls the same, during lacing of the first tensioning element, toward the instep region. A second tensioning element has two ends fixed at the sole. The second tensioning element engages into the second tensioning part and pulls the same, during lacing of the first tensioning element, toward the sole. The first and second tensioning parts are connected together via a tensioning element.

Abstract: A system and method for remotely monitoring and diagnosing a device is disclosed. Data related to the device is obtained at a first network. The obtained data is encrypted to generate an encrypted code at the first network. A copy of the encrypted code is obtained at a second network that is separated from the first network via a non-network medium such as an air gap. The copy of the encrypted code is decoded to obtain the data related to the device at the second network. The data is used at the second network to monitor and diagnose the device at the second network.

Abstract: A valve includes a housing that surrounds a fluid outlet, a valve element with a longitudinal axis, a valve seat body that surrounds a fluid inlet and which has a sealing seat such that the valve is closed when the valve element bears against the sealing seat and which is coupled to the housing. The valve element is movable relative to the valve seat body in a direction of the longitudinal axis to enable a fluid flow from the fluid inlet to the fluid outlet, the valve seat body surrounds a guide surface to which the valve element is coupled in order to guide the movement of the valve element, and the valve seat body is formed from a harder material than the housing.

Abstract: A solenoid valve includes a housing, a valve actuation device, and a closing element, wherein the housing includes an interior space with a central axis, wherein the valve actuation device includes an actuator arranged in the interior space so as to be displaceable along the central axis, wherein the actuator is operatively connected to the closing element such that the solenoid valve is opened or closed by a displacement of the actuator along the central axis, wherein the actuator together with the housing delimit, in the interior space of the housing, a leakage chamber that can be filled with a fluid, e.g., a fuel, and wherein in the leakage chamber, at least one vortex generator is arranged on the housing and/or on the actuator, which vortex generator is configured to generate a fluid vortex in the leakage chamber.

Abstract: A valve includes a spring with a spring force, an actuator with an actuator force which can act against the spring force, a pin which can be actuated by the actuator, a sealing element which can be coupled with the pin, and a seal seat such that the valve is closed when the sealing element rests against the seal seat. The pin can be moved in the direction of the sealing element by means of the actuator, and the pin can be moved in the direction away from the sealing element by means of the spring. The sealing element can be moved into an open position independently of the pin, wherein a fluid flow through the valve is released in the open position.

Abstract: The invention relates to a shoe (in particular to a sports shoe, which has a shoe upper part (2) and a sole (3) which is connected to the shoe upper part (2), wherein the shoe upper part (2) having two tensioning sections (6, 7) which are arranged adjacently in a tensioning region (4) and are separated by a gap (5), wherein a fastening system (8) is arranged by which the shoe (1) can be fastened to the foot of the wearer of the shoe (1) by means of a fastening lace (9) as a result of the adjacently arranged tensioning sections (6, 7) being drawn towards one another.

Abstract: A shoe, which has a shoe upper part and a sole connected to the shoe upper part. The shoe upper part and the sole are connected together by a connection element. In order to simplify the connection between the shoe upper part and the sole and so the connection is stable and water proof, the connection element is a longitudinally extending, profiled molded part that has an upper stripe-shaped section and a lower fork-shaped section which has two fork sections. The shoe upper part has a stripe-shaped upper part section in its region that adjoins the sole, which stripe-shaped upper part section is connected to the strip-shaped section of the connecting element. The sole has a stripe-shaped sole section in its region that adjoins the shoe upper part, which strip-shaped sole section extends between the two fork sections and is connected to at least one of the fork sections.

Abstract: A height-adjustable safety steering column assembly includes a console installed securely on the vehicle and in which an outer jacket tube is pivotably mounted. The outer jacket tube comprising includes a steering spindle having a universal joint and an inner jacket tube, which surrounds a telescoping steering wheel-side section of the steering spindle. The pivotable connection of the outer jacket tube with the console installed securely on the vehicle is implemented by two riveted joints provided diametrically on a circumference of the jacket tube and which form a rotation axis corresponding to the universal joint axis of the steering spindle. For each of the connections formed by two rivets, the console installed securely on the vehicle has a passage leading into a passage of the outer jacket tube. A rivet closing head is seated on the jacket tube side.