Abstract: Disclosed is a runway alerting method and system for an aircraft performing a landing maneuver. During the landing maneuver, a minimum stopping position and a maximum stopping position for the aircraft along the runway is determined using aircraft energy state, deceleration and braking information. The minimum stopping position is based upon the aircraft performing a maximum flare maneuver prior to touchdown on the runway and the maximum stopping position is based upon the aircraft performing a minimum flare maneuver prior to touchdown on the runway. The minimum and maximum stopping positions are presented to the aircraft pilot on a display to assist the pilot in safely landing the aircraft.

Abstract: Disclosed is a runway alerting method and system for an aircraft during a take-off maneuver. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display.

Abstract: Disclosed is a runway alerting method and system for an aircraft during a take-off maneuver. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display.

Abstract: A durable pet having a flat polyurethane foam core, a first polyurethane layer bonded to the top surface of the core, and a second polyurethane layer bonded to the sides of the core, and a method for making such a bed. The first polyurethane layer has a thickness of about 0.05 to 0.25 inches and a hardness of about 20 to 70 durometers. The second polyurethane layer has a thickness of about 0.05 to 0.3 inches and a hardness of about 50 to 100 durometers. The pet bed may have a third polyurethane layer bonded to the bottom of the core, the third layer having a thickness of about 0.05 to 0.25 inches and a hardness of about 20 to 100 durometers. The first, second and third layers typically completely encase the core.

Abstract: Disclosed is a runway alerting method and system for a landing an aircraft. The method includes determining stopping positions for the aircraft along the runway using aircraft energy state, deceleration and braking information and displaying the stopping positions on a display. A system is provided that includes a first apparatus that is configured to determine an aircraft speed relative to the ground, a second apparatus that is configured to determine the aircraft's position, and a third apparatus that can provide information about the runway of intended landing. A flight system coupled to the first and second apparatus is configured to determine a minimum and corporate stopping position for the aircraft using the aircraft speed and the position relative to the runway. The minimum and corporation stopping positions are presented to the aircraft pilot on a display to as assist the pilot in safely landing the aircraft.

Abstract: The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate-Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.

Abstract: The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate-Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.

Abstract: The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.