Abstract: The present invention relates to polymorphs of the mesylate salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form A and Form B of the mesylate salt of linaprazan glurate. The invention also relates to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (cGERD).

Abstract: The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

Abstract: The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

Abstract: Methods and devices are arranged for managing reset and re-downloaded profiles Over-the-Air on an eUICC. An operator system imports a profiles list from a server, each entry in the list comprising a flag indicating whether the corresponding profile has been downloaded onto the eUICC. Upon receiving, from a mobile network operator, MNO, a request to update a profile on the eUICC, the request comprising a profile identifier and an OTA campaign, the operator system performs a backlog of the OTA campaign for the profile indicated by the profile identifier under consideration of the flag in the corresponding profile entry.

Abstract: The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

Abstract: The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

Abstract: The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

Abstract: Methods and devices are arranged for managing reset and re-downloaded profiles Over-the-Air on an eUICC. An operator system imports a profiles list from a server, each entry in the list comprising a flag indicating whether the corresponding profile has been downloaded onto the eUICC. Upon receiving, from a mobile network operator, MNO, a request to update a profile on the eUICC, the request comprising a profile identifier and an OTA campaign, the operator system performs a backlog of the OTA campaign for the profile indicated by the profile identifier under consideration of the flag in the corresponding profile entry.

Abstract: The present invention provides methods for improving flesh quality in farmed fish, and in particular decreasing gaping in fillets from farmed fish as well as increasing flesh and fillet firmness.

Abstract: A method for downloading a profile from a subscription management server (SM-DP+) to a security enclave comprised in an enterprise mobile radio device.

Abstract: A method for performing a switch from a first mobile network to a second mobile network by a mobile terminal comprising a secure element includes the following steps: attaching to the first mobile network using a first subscription profile; downloading a second subscription profile from a subscription management server including a command script defining a sequence of commands; attaching to the second mobile network; and executing the sequence of commands defined by the command script.

Abstract: A method for using a network and a secure element, whereby the secure element of a device receives a request for usages data from the device. The secure element sends the usage data to the device in response to the request. The usage data enable the device to use the network. The secure element applies a timer to measure a delay time. The device shall only use the network, after the delay time has expired. The secure element prevents the usage of the network by the device until the delay time has expired.

Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat).

Abstract: A method for providing a secure element having a processor and a memory of a mobile terminal with a target subscription profile for communicating via a target mobile network comprises the steps of: providing as a first part of the target subscription profile a subscription management interface to the secure element; implementing the subscription management interface on the secure element; and providing as a second part of the target subscription profile subscription data in a format defined by the operator of the target mobile network to the secure element, wherein the subscription management interface allows the secure element to process the subscription data and to implement the target subscription profile thereon for allowing access to the target mobile network. A corresponding secure element, mobile terminal and subscription management backend system includes features associated with the method.

Abstract: A profile management engine receives, from a mobile device management (MDM) server configured to manage one or more mobile devices, an activation request to activate a subscription for a mobile device of the plurality of mobile devices. The profile management engine generates a download request for preparing a download of an electronic subscriber profile to the mobile device, transmits the download request to a subscription management system of a network operator, and subsequently receives a download response from the subscription management system. The download response includes an identifier that identifies an electronic subscriber profile generated for the mobile device.

Abstract: A profile management engine receives, from a mobile device management (MDM) server configured to manage one or more mobile devices, an activation request to activate a subscription for a mobile device of the plurality of mobile devices. The profile management engine generates a download request for preparing a download of an electronic subscriber profile to the mobile device, transmits the download request to a subscription management system of a network operator, and subsequently receives a download response from the subscription management system. The download response includes an identifier that identifies an electronic subscriber profile generated for the mobile device.

Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat).

Abstract: A method of performing a switch from a first mobile network to a second mobile network by a mobile terminal comprising a secure element comprises the steps of: (a) requesting attachment to the first mobile network using a first identification data element, preferably a first IMSI, of a first subscription profile; (b) requesting attachment to the second mobile network using a second identification data element, preferably a second IMSI, of a second subscription profile; and (c) requesting attachment to the first mobile network. The second mobile network or another mobile network uses a confirmation data element, wherein the confirmation data element has the same format as the first and the second identification data element and is configured such that the attachment request is forwarded to a subscription management server in order to inform the subscription management server whether the attachment to the second mobile network was successful.

Abstract: A method for providing a secure element having a processor and a memory of a mobile terminal with a target subscription profile for communicating via a target mobile network comprises the steps of: providing as a first part of the target subscription profile a subscription management interface to the secure element; implementing the subscription management interface on the secure element; and providing as a second part of the target subscription profile subscription data in a format defined by the operator of the target mobile network to the secure element, wherein the subscription management interface allows the secure element to process the subscription data and to implement the target subscription profile thereon for allowing access to the target mobile network. A corresponding secure element, mobile terminal and subscription management backend system includes features associated with the method.

Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat).