Patents by Inventor Thomas Lee

Thomas Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260130396
    Abstract: D-psicose/erythritol compositions comprise, in combination, D-psicose and erythritol as sweeteners together with one or more other edible ingredients. Comestibles are provided, including beverage products and other food products, comprising the novel D-psicose/erythritol compositions. D-psicose and erythritol may each be present in a comestible in a concentration sufficient independently of the other to perceptibly sweeten the composition. An additional sweetener component and other ingredients may be included in the formulation.
    Type: Application
    Filed: October 7, 2025
    Publication date: May 14, 2026
    Applicant: PepsiCo, Inc.
    Inventors: Zena BELL, Thomas LEE, Gregory YEP
  • Publication number: 20260115324
    Abstract: Provided herein are RNA sequences encoding a chimeric antigen receptor (CAR) comprising a CD19 antigen binding molecule, along with related compositions and methods. In some embodiments, circular RNAs encoding the CD19 binding molecule or CD19 CAR, along with related compositions, methods, and precursors, are described herein. In some embodiments, these compositions comprise a transfer vehicle, e.g., comprising an ionizable lipid described herein.
    Type: Application
    Filed: August 1, 2025
    Publication date: April 30, 2026
    Applicants: Orna Therapeutics, Inc., ReNAgade Therapeutics Management Inc.
    Inventors: Isin Dalkilic-Liddle, Robert Mabry, Thomas Lee, Karolina Anna Kosakowska, Muthusamy Jayaraman, Ganapathy Subramanian Sankaran
  • Publication number: 20260115228
    Abstract: Provided herein are RNA sequences encoding a chimeric antigen receptor (CAR) comprising a CD19 antigen binding molecule, along with related compositions and methods. In some embodiments, circular RNAs encoding the CD19 binding molecule or CD19 CAR, along with related compositions, methods, and precursors, are described herein. In some embodiments, these compositions comprise a transfer vehicle, e.g., comprising an ionizable lipid described herein.
    Type: Application
    Filed: August 1, 2025
    Publication date: April 30, 2026
    Applicants: Orna Therapeutics, Inc., ReNAgade Therapeutics Management Inc.
    Inventors: Isin Dalkilic-Liddle, Robert Mabry, Thomas Lee, Karolina Anna Kosakowska, Muthusamy Jayaraman, Ganapathy Subramanian Sankaran
  • Patent number: 12599679
    Abstract: Provided herein are circular RNA constructs comprising an IRES, and at least one expression sequence encoding binding molecule, compositions thereof, and methods of treatment, including for cancer and autoimmune disease. In particular, circular RNA comprising an IRES and a CD19 binder, a HER2 binder, or a BCMA binder are provided, optionally formulated with a delivery vehicle. Precursor polynucleotides comprising an IRES, and at least one expression sequence encoding a CAR construct are also described herein.
    Type: Grant
    Filed: May 7, 2025
    Date of Patent: April 14, 2026
    Assignee: Orna Therapeutics, Inc.
    Inventors: Amy M. Becker, Robert Alexander Wesselhoeft, IV, Akinola O. Emmanuel, Jui Dutta-Simmons, Allen T. Horhota, Kevin J. Kauffman, Bun Chau, Thomas Lee
  • Publication number: 20260079072
    Abstract: Apparatuses and methods for compressed fluid vessel monitoring can permit a user to more easily order replacement vessels, monitor use, monitor inventory and return empty vessels. Embodiments can utilize a collar connectable to a vessel to help facilitate such functionality. The collar can be adapted to transmit signals to a data processing system. The data processing system can be adapted to permit a user to track the location and fill status of the vessel as well as order a replacement vessel and disposal or return of an empty vessel. Instrumented vessels can also convey sensor data to help identify a leak condition or other condition of the vessel. In some embodiments, the data processing system can be adapted for integration into a user's inventory system and/or purchasing system as well as a supplier's system to facilitate communications concerning vessel fill status, reorder, and/or vessel return.
    Type: Application
    Filed: November 25, 2025
    Publication date: March 19, 2026
    Applicant: Air Products and Chemicals, Inc.
    Inventors: Thomas Lee, David Bryant, Thomas Holbeche, Stephen Mellor, Phil Tranter, Csaba Alfoldi, Craig Hunt, Matthew Isbell
  • Publication number: 20260075087
    Abstract: Aspects of the disclosure relate to identifying potentially malicious messages and generating instream alerts based on real-time message monitoring. A computing platform may monitor a plurality of messages received by a messaging server associated with an operator. Subsequently, the computing platform may detect that a message of the plurality of messages is potentially malicious. In response to detecting that the message of the plurality of messages is potentially malicious, the computing platform may execute one or more protection actions. In executing the one or more protection actions, the computing platform may generate an alert message comprising information indicating that the message of the plurality of messages is potentially malicious. Then, the computing platform may send the alert message to the messaging server, which may cause the messaging server to deliver the alert message to a computing device associated with an intended recipient of the message.
    Type: Application
    Filed: November 12, 2025
    Publication date: March 12, 2026
    Inventor: Thomas Lee
  • Patent number: 12529621
    Abstract: Apparatuses and methods for compressed fluid vessel monitoring can permit a user to more easily order replacement vessels, monitor use, monitor inventory and return empty vessels. Embodiments can utilize a collar connectable to a vessel to help facilitate such functionality. The collar can be adapted to transmit signals to a data processing system. The data processing system can be adapted to permit a user to track the location and fill status of the vessel as well as order a replacement vessel and disposal or return of an empty vessel. Instrumented vessels can also convey sensor data to help identify a leak condition or other condition of the vessel. In some embodiments, the data processing system can be adapted for integration into a user's inventory system and/or purchasing system as well as a supplier's system to facilitate communications concerning vessel fill status, reorder, and/or vessel return.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: January 20, 2026
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Thomas Lee, David Bryant, Thomas Holbeche, Stephen Mellor, Phil Tranter, Csaba Alfoldi, Craig Hunt, Matthew Isbell
  • Patent number: 12500926
    Abstract: Aspects of the disclosure relate to identifying potentially malicious messages and generating instream alerts based on real-time message monitoring. A computing platform may monitor a plurality of messages received by a messaging server associated with an operator. Subsequently, the computing platform may detect that a message of the plurality of messages is potentially malicious. In response to detecting that the message of the plurality of messages is potentially malicious, the computing platform may execute one or more protection actions. In executing the one or more protection actions, the computing platform may generate an alert message comprising information indicating that the message of the plurality of messages is potentially malicious. Then, the computing platform may send the alert message to the messaging server, which may cause the messaging server to deliver the alert message to a computing device associated with an intended recipient of the message.
    Type: Grant
    Filed: May 2, 2023
    Date of Patent: December 16, 2025
    Assignee: Proofpoint, Inc.
    Inventor: Thomas Lee
  • Publication number: 20250356195
    Abstract: Computer-implemented systems, products, and methods for receiving data characterizing a set of user-define parameters from a first entity including at least a target assessment rating and a target time duration; simulating, based on the received data, one or more scenarios, wherein each of the one or more scenarios is associated with a set of action items; determining a total score for each set of action items for each scenario; removing, using an analytic decision tree, any scenario from the one or more scenarios that includes a total score that fails to satisfy a set of predetermined criteria; determining an efficiency factor associated with each of the one or more remaining scenarios; and providing the remaining one or more scenarios in a hierarchical position based on the efficiency factor.
    Type: Application
    Filed: April 16, 2025
    Publication date: November 20, 2025
    Inventors: Scott ZOLDI, Jeremy SCHMITT, Qing LIU, Thomas QUINN, Paul PANICHELLI, Prasanth GOPINATHAN, Steven HU, Thomas LEE
  • Patent number: 12462777
    Abstract: A support garment for a stringed musical instrument is an apparatus that provides more comfort to a musical instrument player by better distributing the load of the instrument on the player's body. The apparatus includes an upper-body garment, a first support strap, a second support strap, and a waist belt. The upper-body garment is worn by the player while playing the instrument. The first support strap and the second support strap allow for the removable attachment of the instrument to the apparatus. The first support strap and the second support strap support the instrument in such a way that the instrument is properly supported by the apparatus without obstructing the player's movements while playing the instrument. The waist belt improves the distribution of the load from the instrument on the player's body by helping secure the first support strap and the second support strap to the upper body garment.
    Type: Grant
    Filed: June 7, 2024
    Date of Patent: November 4, 2025
    Inventor: Thomas Lee
  • Patent number: 12458045
    Abstract: D-psicose/erythritol compositions comprise, in combination, D-psicose and erythritol as sweeteners together with one or more other edible ingredients. Comestibles are provided, including beverage products and other food products, comprising the novel D-psicose/erythritol compositions. D-psicose and erythritol may each be present in a comestible in a concentration sufficient independently of the other to perceptibly sweeten the composition. An additional sweetener component and other ingredients may be included in the formulation.
    Type: Grant
    Filed: September 18, 2023
    Date of Patent: November 4, 2025
    Assignee: PepsiCo, Inc.
    Inventors: Zena Bell, Thomas Lee, Gregory Yep
  • Publication number: 20250262324
    Abstract: Provided herein are circular RNA constructs comprising an IRES, and at least one expression sequence encoding binding molecule, compositions thereof, and methods of treatment, including for cancer and autoimmune disease. In particular, circular RNA comprising an IRES and a CD19 binder, a HER2 binder, or a BCMA binder are provided, optionally formulated with a delivery vehicle. Precursor polynucleotides comprising an IRES, and at least one expression sequence encoding a CAR construct are also described herein.
    Type: Application
    Filed: May 7, 2025
    Publication date: August 21, 2025
    Applicant: Orna Therapeutics, Inc.
    Inventors: Amy M. Becker, Robert Alexander Wesselhoeft, IV, Akinola O. Emmanuel, Jui Dutta-Simmons, Allen T. Horhota, Kevin J. Kauffman, Bun Chau, Thomas Lee
  • Publication number: 20250203371
    Abstract: Aspects of the disclosure relate to providing secure shortened URLs in character-limited messages. A computing platform may receive one or more character-limited messages sent to a user device. The computing platform may detect a URL within the one or more character-limited messages for replacement and generate a shortened URL corresponding to the detected URL, wherein a domain of the shortened URL is hosted by the message security system. The computing platform may then modify the one or more character-limited messages by replacing the URL with the shortened URL, and then cause transmission of the modified one or more character-limited messages to the user device. Next, the computing platform may receive, from the user device, a request to access the shortened URL, and redirect the user device to the detected URL corresponding to the shortened URL.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventor: Thomas Lee
  • Patent number: 12273719
    Abstract: Aspects of the disclosure relate to providing secure shortened URLs in character-limited messages. A computing platform may receive one or more character-limited messages sent to a user device. The computing platform may detect a URL within the one or more character-limited messages for replacement and generate a shortened URL corresponding to the detected URL, wherein a domain of the shortened URL is hosted by the message security system. The computing platform may then modify the one or more character-limited messages by replacing the URL with the shortened URL, and then cause transmission of the modified one or more character-limited messages to the user device. Next, the computing platform may receive, from the user device, a request to access the shortened URL, and redirect the user device to the detected URL corresponding to the shortened URL.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: April 8, 2025
    Assignee: Proofpoint, Inc.
    Inventor: Thomas Lee
  • Publication number: 20250106179
    Abstract: Aspects of the disclosure relate to providing commercial and/or spam messaging detection and enforcement. A computing platform may receive a plurality of text messages from a sender. It may then tokenize the plurality of text messages to yield a plurality of tokens. The computing platform may then match one or more tokens of the plurality of tokens in the plurality of text messages to one or more bulk string tokens. Next, it may detect one or more homoglyphs in the plurality of text messages, and then detect one or more URLs in the plurality of text messages. The computing platform may flag the sender based at least on the one or more matching tokens, the one or more detected homoglyphs, and the one or more detected URLs. Based on flagging the sender, the computing platform may block one or more messages from the sender.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Inventors: Thomas Lee, Sarah Solieman
  • Publication number: 20250080354
    Abstract: Aspects of the disclosure relate to message verification. A computing platform may generate a cryptographic key pair comprising a public key and a private key. The computing platform may publish, to a server, the public key. The computing platform may generate a short message service (SMS) message. The computing platform may sign, using the private key, the SMS message, which may include computing a cryptographic hash of the SMS message using the private key and embedding the cryptographic hash in an SMPP field of the SMS message. The computing platform may send, to a downstream computing system, the signed SMS message, where the downstream computing system may be configured to validate the signed SMS message using the cryptographic hash embedded in the SMPP field of the SMS message and by accessing the public key.
    Type: Application
    Filed: November 20, 2024
    Publication date: March 6, 2025
    Inventors: Thomas Lee, Kevin San Diego
  • Publication number: 20250063020
    Abstract: Aspects of the disclosure relate to detecting and preventing transmission of spam messages using modified source numbers. A computing platform may detect that a first message, sent to a recipient device from a sender device, includes suspicious content. Subsequently, the computing platform may receive, from the recipient device, user interaction information indicating that a user of the recipient device has sent a reply message in response to the first message. Then, the computing platform may generate a modified message by modifying a first source number corresponding to the reply message. Next, the computing platform may cause transmission of the modified message with the modified first source number to the sender device. Thereafter, the computing platform may intercept one or more additional messages between the sender device and the modified first source number and redirect the one or more additional messages.
    Type: Application
    Filed: November 4, 2024
    Publication date: February 20, 2025
    Inventor: Thomas Lee
  • Patent number: 12224983
    Abstract: Aspects of the disclosure relate to detecting and preventing transmission of spam messages using modified source numbers. A computing platform may detect that a first message, sent to a recipient device from a sender device, includes suspicious content. Subsequently, the computing platform may receive, from the recipient device, user interaction information indicating that a user of the recipient device has sent a reply message in response to the first message. Then, the computing platform may generate a modified message by modifying a first source number corresponding to the reply message. Next, the computing platform may cause transmission of the modified message with the modified first source number to the sender device. Thereafter, the computing platform may intercept one or more additional messages between the sender device and the modified first source number and redirect the one or more additional messages.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: February 11, 2025
    Assignee: Proofpoint, Inc.
    Inventor: Thomas Lee
  • Patent number: 12199933
    Abstract: Aspects of the disclosure relate to providing commercial and/or spam messaging detection and enforcement. A computing platform may receive a plurality of text messages from a sender. It may then tokenize the plurality of text messages to yield a plurality of tokens. The computing platform may then match one or more tokens of the plurality of tokens in the plurality of text messages to one or more bulk string tokens. Next, it may detect one or more homoglyphs in the plurality of text messages, and then detect one or more URLs in the plurality of text messages. The computing platform may flag the sender based at least on the one or more matching tokens, the one or more detected homoglyphs, and the one or more detected URLs. Based on flagging the sender, the computing platform may block one or more messages from the sender.
    Type: Grant
    Filed: March 5, 2024
    Date of Patent: January 14, 2025
    Assignee: Proofpoint, Inc.
    Inventors: Thomas Lee, Sarah Solieman
  • Patent number: 12192363
    Abstract: Aspects of the disclosure relate to message verification. A computing platform may generate a cryptographic key pair comprising a public key and a private key. The computing platform may publish, to a server, the public key. The computing platform may generate a short message service (SMS) message. The computing platform may sign, using the private key, the SMS message, which may include computing a cryptographic hash of the SMS message using the private key and embedding the cryptographic hash in an SMPP field of the SMS message. The computing platform may send, to a downstream computing system, the signed SMS message, where the downstream computing system may be configured to validate the signed SMS message using the cryptographic hash embedded in the SMPP field of the SMS message and by accessing the public key.
    Type: Grant
    Filed: September 29, 2023
    Date of Patent: January 7, 2025
    Assignee: Proofpoint, Inc.
    Inventors: Thomas Lee, Kevin San Diego